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View Structure Prediction Details

Protein: RGD1
Organism: Saccharomyces cerevisiae
Length: 666 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RGD1.

Description E-value Query
Range
Subject
Range
RGD1_YEAST - RHO GTPase-activating protein RGD1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RGD1 ...
gi|151946647 - gi|151946647|gb|EDN64869.1| GTPase-activating protein [Saccharomyces cerevisiae YJM789]
RGD1 - GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytosk...
gi|190408589 - gi|190408589|gb|EDV11854.1| protein RGD1 [Saccharomyces cerevisiae RM11-1a]
0.0 [1..666] [1..666]
gi|2598189 - gi|2598189|gb|AAB84002.1| GTPase activating protein homolog [Cochliobolus heterostrophus]
0.0 [4..666] [64..714]
RGA7_SCHPO - Probable Rho-GTPase-activating protein 7 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=r...
rga7 - GTPase activating protein Rga7
3.0E-88 [4..666] [7..695]
gi|27597098, gi|... - gi|27597098|ref|NP_536696.2| brain stress early protein Gbi isoform 1 [Mus musculus], gi|14028714|gb...
3.0E-84 [101..664] [15..583]
gi|25535897, gi|... - gi|3413874|dbj|BAA32301.1| KIAA0456 protein [Homo sapiens], pir||C59437 KIAA0456 protein [imported] ...
4.0E-84 [33..664] [43..704]

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Predicted Domain #1
Region A:
Residues: [1-435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEETAKKPAS ATVSAKSSHD GGTDDLAHLF STPEIKKVLN SDVAINALLS RLKQSLLTCE  60
   61 EFMKFIRKKY AFEEEHVQEL SKQYKHFFNI QGSTNSSLKK MIHEVLGFDG KMAQVKQSYI 120
  121 TALQKMYSEI SSLLLTMTKL RKSVKENSKR LEKDVSDAIH SAEKAQSRYN SLCQDWDKLR 180
  181 MTDPTKTKLT LRGSKTTKEQ EEELLRKIDN ADLEYKQKVD HSNSLRNTFI TKERPRIVQE 240
  241 LKDLILEIDT AMTIQLQKYT IWTENLVLNT GVTISPLDST KSMKSFAGSV SNERDLYSFL 300
  301 NKYNQTGKHS LLINKNLIPV SYKKHPSMNH GQKNKSPPKF AVDPSRNSIP KRMISTHNES 360
  361 PFLSSSSNTA AVPNANLNSA TPSLNTNKQL PPTMASSISS TSNAAGAMSP SSSIVTSDTT 420
  421 SSITKTLDPG NNSPQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.39794
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.43584893484993 bayes_pls_golite062009
protein binding 1.87308005875135 bayes_pls_golite062009
cytoskeletal protein binding 1.48820833936343 bayes_pls_golite062009
signal transducer activity 0.546501086239797 bayes_pls_golite062009
molecular transducer activity 0.546501086239797 bayes_pls_golite062009
GTPase binding 0.50066793947946 bayes_pls_golite062009
GTPase regulator activity 0.459881864914566 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.456472132383968 bayes_pls_golite062009
enzyme regulator activity 0.180886944097381 bayes_pls_golite062009
small GTPase binding 0.0531578648468707 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [436-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPEELINSLD SDRPISHIQT NNNMPPGVQK NFKTFGVPLE SLIEFEQDMV PAIVRQCIYV  60
   61 IDKFGLDQEG IYRKSANVLD VSKLKEEIDK DPANISMILP SKPHSDSDIY LVGSLLKTFF 120
  121 ASLP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.70927
Match: 1rgp__
Description: p50 RhoGAP domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Rho GTPase activator activity 4.58620967349979 bayes_pls_golite062009
Rac GTPase activator activity 3.29568423512865 bayes_pls_golite062009
GTPase regulator activity 2.70614727793157 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.68579854252375 bayes_pls_golite062009
binding 2.36195429973813 bayes_pls_golite062009
actin binding 2.22794146985308 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 2.06038764955701 bayes_pls_golite062009
cytoskeletal protein binding 2.05040620031468 bayes_pls_golite062009
enzyme regulator activity 1.9750017471254 bayes_pls_golite062009
small GTPase regulator activity 1.95738547986197 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
Ras GTPase activator activity 1.09070479183477 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.958295643211986 bayes_pls_golite062009
GTPase activator activity 0.717730683557543 bayes_pls_golite062009
microfilament motor activity 0.70891877343852 bayes_pls_golite062009
signal transducer activity 0.648419213388211 bayes_pls_golite062009
molecular transducer activity 0.648419213388211 bayes_pls_golite062009
actin filament binding 0.613502134123252 bayes_pls_golite062009
motor activity 0.55239878540339 bayes_pls_golite062009
diacylglycerol binding 0.515403424540209 bayes_pls_golite062009
tubulin binding 0.477476507404761 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.36751853312336 bayes_pls_golite062009
transcription regulator activity 0.348246993470003 bayes_pls_golite062009
enzyme activator activity 0.298334474872045 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [560-666]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSVLPKALSS EIKVCLQIED PTTRKNFMHG LIYNLPDAQY WTLRALVFHL KRVLAHEAQN  60
   61 RMNLRALCII WGPTIAPANP DDANDVNFQI MAMEVLLEVS DQAFEPE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.70927
Match: 1rgp__
Description: p50 RhoGAP domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle