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Protein Overview: MNL1

General Information:
Name(s) found: MNL1 / YHR204W [SGD]
Description(s) found:
Found 23 descriptions.
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  • alpha-1,2-specific exomannosidase of the endoplasmic reticulum that generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 796 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: ER-associated protein catabolic process [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: carbohydrate binding [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVCCLWVLLA LLLHLDHVAC EDDAYSFTSK ELKAYKQEVK ELFYFGFDNY LEHGYPYDEV  60
   61 KPISCVPKKR NFEDPTDQGT NDILGNFTIT LIDSLTTIAI LEDRPQFLKA VRLVERTFPD 120
  121 GNFDIDSTIQ VFEITIRVIG SLLSSHLYAT DPTKAVYLGD DYDGSLLRLA QNMADRLLPA 180
  181 YLTSTGLPMP RRNIKRKWDV SEFPEFLETE NNVAAMASPM FEFTILSYLT GDPKYEKVTR 240
  241 YAFDKTWSLR TGLDLLPMSF HPEKLTPYTP MTGIGASIDS LFEYALKGAI LFDDSELMEV 300
  301 WNVAYEALKT NCKNDWFFAN VMADTGHLFV PWIDSLSAFF SGLQVLAGDL DDAIANHLMF 360
  361 LKMWNTFGGI PERWNFSPPE FPPLSPLERS GAVALDNILP LEWYPLRPEF FESTYFLYRA 420
  421 TKDPFYLNIG VHLLKDLKQR FKSNCGFAGF QNVITGELQD RMETFVLSET LKYLYLLFDE 480
  481 ENELHNSASD VIFSTEAHPM WLPQEVRSNY KRNAKFNNSV YSSHLEICQK KDREQAGENT 540
  541 LSQRIVGFAK SIFHKGPPDE EATDPIIDYT IDTELPGTCS IKPHHVIGDE FWYSPMLSNF 600
  601 DRLFEIDSRF AATLIKPSHM HNYNAIELEP GFYNRWSNPQ FSTCLIPPTT EIFELLFDLP 660
  661 GYHQLNPLML ENKTITFETF GGRSRLKIEK LQIYQIDYYG DLITASTFQD VSRKDIFSNA 720
  721 CDAVASLYSP TYLYRVVAIN GRILPRHGSV QIKKHSPVLT SNGTREEDEF KMDGIGINDH 780
  781 SQLMLECTPI INLFIV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HEM13 MNL1 PDI1
    View Details Gavin AC, et al. (2002) ACE2 ALT2 BCK1 CDC11 DRE2 ECM30 ENP2 IML1 MNL1 MTR4 MYO2 RGC1 SEC3 UBP15 YBL044W YJR098C YNL313C
    View Details Qiu et al. (2008) MNL1 PUF2 RIA1 RKI1 RPL12B, RPL12A RPL14A RPL14B RPL19B, RPL19A RPL20B RPL21A RPL21B RPL22A RPL22B RPL24A RPL26A RPL33B RPL34A RPL35A, RPL35B RPL36A RPL37A RPL37B RPL41A, RPL41B RPL42B, RPL42A RPL43B, RPL43A RPL8A RPL9A RPL9B RPP1B RPP2A RPS0A RPS0B RPS11A, RPS11B RPS16B, RPS16A RPS17B RPS19B RPS1B RPS21B RPS23B, RPS23A RPS24A, RPS24B RPS25B RPS26A RPS27A RPS27B RPS30B, RPS30A RPS6A, RPS6B RPS7B RPS8B, RPS8A SOP4 TOS4 YPL199C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MNL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..304]
    [459..571]    		 PSI-BLAST 439.9691 Class I alpha-1;2-mannosidase, catalytic domain
    2 View Details [305..458] PSI-BLAST 439.9691 Class I alpha-1;2-mannosidase, catalytic domain
    3 View Details [572..796] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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