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View Structure Prediction Details

Protein: MNL1
Organism: Saccharomyces cerevisiae
Length: 796 amino acids
Reference: Malmstr÷m L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MNL1.

Description E-value Query
Range
Subject
Range
MNL1 - alpha-1,2-specific exomannosidase of the endoplasmic reticulum that generates a Man7GlcNac2 oligosac...
gi|151944149 - gi|151944149|gb|EDN62442.1| mannosidase-like protein [Saccharomyces cerevisiae YJM789]
MNL1_YEAST - ER degradation-enhancing alpha-mannosidase-like protein 1 OS=Saccharomyces cerevisiae (strain ATCC 2...
0.0 [1..796] [1..796]
MAN1A2 - mannosidase, alpha, class 1A, member 2
gi|168278008 - gi|168278008|dbj|BAG10982.1| mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [synthetic construct]
0.0 [26..504] [171..628]
MA1A1_MOUSE - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA OS=Mus musculus GN=Man1a1 PE=1 SV=1
0.0 [8..505] [169..645]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [12..515] [182..659]
MA1A1_RABIT - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (Fragment) OS=Oryctolagus cuniculus GN=MAN1A1 PE=1...
0.0 [26..515] [2..469]
alpha-Man-I-PJ, ... - The gene ├?Ž├?┬▒ Mannosidase I is referred to in FlyBase by the symbol Dmel\├?Ž├?┬▒-Man-I ...
0.0 [18..514] [183..657]

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Predicted Domain #1
Region A:
Residues: [1-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVCCLWVLLA LLLHLDHVAC EDDAYSFTSK ELKAYKQEVK ELFYFGFDNY LEHGYPYDEV  60
   61 KPISCVPKKR NFEDPTDQGT NDILGNFTIT LIDSLTTIAI LEDRPQFLKA VRLVERTFPD 120
  121 GNFDIDSTIQ VFEITIRVIG SLLSSHLYAT DPTKAVYLGD DYDGSLLRLA QNMADRLLPA 180
  181 YLTSTGLPMP RRNIKRKWDV SEFPEFLETE NNVAAMASPM FEFTILSYLT GDPKYEKVTR 240
  241 YAFDKTWSLR TGLDLLPMSF HPEKLTPYTP MTGIGASIDS LFEYALKGAI LFDDSELMEV 300
  301 WNVA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [459-571]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDRMETFVLS ETLKYLYLLF DEENELHNSA SDVIFSTEAH PMWLPQEVRS NYKRNAKFNN  60
   61 SVYSSHLEIC QKKDREQAGE NTLSQRIVGF AKSIFHKGPP DEEATDPIID YTI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 439.9691
Match: 1fmiA_
Description: Class I alpha-1;2-mannosidase, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [305-458]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEALKTNCKN DWFFANVMAD TGHLFVPWID SLSAFFSGLQ VLAGDLDDAI ANHLMFLKMW  60
   61 NTFGGIPERW NFSPPEFPPL SPLERSGAVA LDNILPLEWY PLRPEFFEST YFLYRATKDP 120
  121 FYLNIGVHLL KDLKQRFKSN CGFAGFQNVI TGEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 439.9691
Match: 1fmiA_
Description: Class I alpha-1;2-mannosidase, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [572-796]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTELPGTCSI KPHHVIGDEF WYSPMLSNFD RLFEIDSRFA ATLIKPSHMH NYNAIELEPG  60
   61 FYNRWSNPQF STCLIPPTTE IFELLFDLPG YHQLNPLMLE NKTITFETFG GRSRLKIEKL 120
  121 QIYQIDYYGD LITASTFQDV SRKDIFSNAC DAVASLYSPT YLYRVVAING RILPRHGSVQ 180
  181 IKKHSPVLTS NGTREEDEFK MDGIGINDHS QLMLECTPII NLFIV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle