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Protein Overview: CHS1

General Information:
Name(s) found: CHS1 / YNL192W [SGD]
Description(s) found:
Found 20 descriptions.
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  • Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1131 amino acids

    Gene Ontology:
    Cellular Component: chitosome [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: cytokinesis, completion of separation [IMPLink to PubMed article]
    cell budding [TASLink to PubMed article]
    Molecular Function: chitin synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDQNNRSRN EYHSNRKNEP SYELQNAHSG LFHSSNEELT NRNQRYTNQN ASMGSFTPVQ  60
   61 SLQFPEQSQQ TNMLYNGDDG NNNTINDNER DIYGGFVNHH RQRPPPATAE YNDVFNTNSQ 120
  121 QLPSEHQYNN VPSYPLPSIN VIQTTPELIH NGSQTMATPI ERPFFNENDY YYNNRNSRTS 180
  181 PSIASSSDGY ADQEARPILE QPNNNMNSGN IPQYHDQPFG YNNGYHGLQA KDYYDDPEGG 240
  241 YIDQRGDDYQ INSYLGRNGE MVDPYDYENS LRHMTPMERR EYLHDDSRPV NDGKEELDSV 300
  301 KSGYSHRDLG EYDKDDFSRD DEYDDLNTID KLQFQANGVP ASSSVSSIGS KESDIIVSND 360
  361 NLTANRALKR SGTEIRKFKL WNGNFVFDSP ISKTLLDQYA TTTENANTLP NEFKFMRYQA 420
  421 VTCEPNQLAE KNFTVRQLKY LTPRETELML VVTMYNEDHI LLGRTLKGIM DNVKYMVKKK 480
  481 NSSTWGPDAW KKIVVCIISD GRSKINERSL ALLSSLGCYQ DGFAKDEINE KKVAMHVYEH 540
  541 TTMINITNIS ESEVSLECNQ GTVPIQLLFC LKEQNQKKIN SHRWAFEGFA ELLRPNIVTL 600
  601 LDAGTMPGKD SIYQLWREFR NPNVGGACGE IRTDLGKRFV KLLNPLVASQ NFEYKMSNIL 660
  661 DKTTESNFGF ITVLPGAFSA YRFEAVRGQP LQKYFYGEIM ENEGFHFFSS NMYLAEDRIL 720
  721 CFEVVTKKNC NWILKYCRSS YASTDVPERV PEFILQRRRW LNGSFFASVY SFCHFYRVWS 780
  781 SGHNIGRKLL LTVEFFYLFF NTLISWFSLS SFFLFFRILT VSIALAYHSA FNVLSVIFLW 840
  841 LYGICTLSTF ILSLGNKPKS TEKFYVLTCV IFAVMMIYMI FCSIFMSVKS FQNILKNDTI 900
  901 SFEGLITTEA FRDIVISLGS TYCLYLISSI IYLQPWHMLT SFIQYILLSP SYINVLNIYA 960
  961 FCNVHDLSWG TKGAMANPLG KINTTEDGTF KMEVLVSSSE IQANYDKYLK VLNDFDPKSE1020
 1021 SRPTEPSYDE KKTGYYANVR SLVIIFWVIT NFIIVAVVLE TGGIADYIAM KSISTDDTLE1080
 1081 TAKKAEIPLM TSKASIYFNV ILWLVALSAL IRFIGCSIYM IVRFFKKVTF R

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) CHS1 ENO2 PGK1
    View Details Ho Y, et al. (2002) ARO1 BCK1 CHS1 CMP2 DBP7 KOG1 KSP1 PRI2 PSY2 TPD3
    View Details Qiu et al. (2008) CHS1 CHS3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] PSI-BLAST 2.69897 Fibrinogen
    2 View Details [143..409] ORFEUS 14.32 RBP1
    3 View Details [410..488] deduced N/A No confident structure predictions are available.
    4 View Details [489..565]
    [696..855]    		 ORFEUS 7.7 Diol dehydratase, alpha subunit
    5 View Details [566..695] ORFEUS 7.7 Diol dehydratase, alpha subunit
    6 View Details [856..908] deduced N/A No confident structure predictions are available.
    7 View Details [909..1131] MSA 1.122952 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transferase activity, transferring hexosyl groups
    		•  2.23446625487311 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  1.84596125277114 bayes_pls_golite062009
  • catalytic activity
    		•  1.73979371332125 bayes_pls_golite062009
  • transferase activity
    		•  1.18156663897445 bayes_pls_golite062009
  • acetylgalactosaminyltransferase activity
    		•  0.823843077041128 bayes_pls_golite062009
  • cytidylyltransferase activity
    		•  0.666765511953956 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.641710647713692 bayes_pls_golite062009
  • binding
    		•  0.61043334112269 bayes_pls_golite062009
  • polypeptide N-acetylgalactosaminyltransferase activity
    		•  0.600389101620522 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.539883035270389 bayes_pls_golite062009
  • glucuronosyltransferase activity
    		•  0.510390802401046 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  0.505948108814334 bayes_pls_golite062009
  • glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
    		•  0.360354014290234 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.301396160525425 bayes_pls_golite062009
  • UDP-N-acetylglucosamine diphosphorylase activity
    		•  0.0309517682490415 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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