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Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. Catalyzes of the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: polypeptide N-acetylgalactosaminyltransferase activity
Acc: GO:0004653
Aspect: Molecular Function
Desc: Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. Catalyzes of the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.
Synonyms:
  • polypeptide-N-acetylgalactosamine transferase activity
  • protein-UDP acetylgalactosaminyltransferase activity
  • UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity
  • UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity
  • UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity
  • UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
  • UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity
  • glycoprotein acetylgalactosaminyltransferase activity
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity
  • UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity
  • UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity
  • UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity
  • UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity
  • uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
Proteins in PDR annotated with:
   This term: 24 [Search]
   Term or descendants: 24 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004653 - polypeptide N-acetylgalactosaminyltransferase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle