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Protein Overview: CRM1

General Information:
Name(s) found: CRM1 / YGR218W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1084 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [IMPLink to PubMed article]
    ribosomal large subunit export from nucleus [IMPLink to PubMed article]
    protein export from nucleus [IMPLink to PubMed article]
    Molecular Function: protein transmembrane transporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK ADQILQFSTN  60
   61 PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS MCQDDEVFKT QKNLINKSDL 120
  121 TLVQILKQEW PQNWPEFIPE LIGSSSSSVN VCENNMIVLK LLSEEVFDFS AEQMTQAKAL 180
  181 HLKNSMSKEF EQIFKLCFQV LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST 240
  241 KFMTSPDTRA ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT 300
  301 YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL SKIEERELFK 360
  361 TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST GSGALNPEYM KRFPLKKHIY 420
  421 EEICSQLRLV IIENMVRPEE VLVVENDEGE IVREFVKESD TIQLYKSERE VLVYLTHLNV 480
  481 IDTEEIMISK LARQIDGSEW SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV 540
  541 KKRGKDNKAV VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI 600
  601 KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI IISEERSVAE 660
  661 RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA NIIKTNVAVC TSMGADFYPQ 720
  721 LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA TKTPKVRGLR TIKKEILKLV ETYISKARNL 780
  781 DDVVKVLVEP LLNAVLEDYM NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC 840
  841 TLDMINKDFT EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV 900
  901 EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS GFSKQALLLM 960
  961 KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS NAFPHLTSEQ IASFLSALTK1020
 1021 QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL FAEDKENALM EQNRLEREKA AKIGGLLKPS1080
 1081 ELDD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CRM1 GEA2 MIR1 YHR020W
    View Details Gavin AC, et al. (2002) BMH1 BMH2 CLU1 CRM1 ECM29 FKS1 GCN1 GEA2 GFA1 HRP1 HSP42 KAP104 KAP123 LCB1 LCB2 LYS12 MIR1 NAB2 NSL1 PDC1 PRP11 SAM1 SAM2 TAT1 YHR020W
    View Details Ho Y, et al. (2002) AAC3 ADR1 ATG12 BBC1 BUD32 CAR2 CDC39 CDC53 CPR6 CRM1 DIA4 DUR1,2 ECM29 ECM33 FAA4 FET3 GAL3 GCN1 GRX3 GRX4 HEF3 HRT1 HYP2 IDP2 IMD2 IMD4 KAE1 KAP122 KGD1 MDN1 MET10 MET18 MKT1 MMS1 MYO2 NPA3 PFK1 PHO81 PMA2 RNH202 RPA190 RPN1 RPN5 RPN6 RPT1 SEC18 SEC23 SGO1 TMA29 TPS1 UBI4 URA7 VPS13 YAR009C YGP1 YHR033W YLR035C-A YRB2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CRM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..746] MSA 33.191997 View MSA. No confident structure predictions are available.
    2 View Details [747..848] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [849..946] ORFEUS 8.41 Hemoglobin, alpha-chain
    4 View Details [947..1084] ORFEUS 8.41 Hemoglobin, alpha-chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  3.48172991171337 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • structural molecule activity
    		•  2.87774614675757 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.74547353635661 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61566088685247 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.34284977509828 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26725422172281 bayes_pls_golite062009
  • signal sequence binding
    		•  2.11631489628537 bayes_pls_golite062009
  • RNA binding
    		•  1.98024495780436 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  1.91487015967262 bayes_pls_golite062009
  • actin binding
    		•  1.76244772281676 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.76231475025891 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • mRNA binding
    		•  1.71342954033223 bayes_pls_golite062009
  • DNA binding
    		•  1.62032607987786 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.09652988954158 bayes_pls_golite062009
  • transcription factor activity
    		•  0.923253759652909 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.83079633551839 bayes_pls_golite062009
  • translation regulator activity
    		•  0.82193201542158 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.803700928110921 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.662662274021266 bayes_pls_golite062009
  • signal transducer activity
    		•  0.662662274021266 bayes_pls_golite062009
  • hydrolase activity
    		•  0.42501390959416 bayes_pls_golite062009
  • importin-alpha export receptor activity
    		•  0.259676026705859 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.248585912061178 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.226380819487924 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.217517113570989 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.178770060806735 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.175241020572885 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.174922130116569 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.11022839198649 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0405268469927988 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0232727461674547 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  3.48172991171337 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • structural molecule activity
    		•  2.87774614675757 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.74547353635661 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61566088685247 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.34284977509828 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26725422172281 bayes_pls_golite062009
  • signal sequence binding
    		•  2.11631489628537 bayes_pls_golite062009
  • RNA binding
    		•  1.98024495780436 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  1.91487015967262 bayes_pls_golite062009
  • actin binding
    		•  1.76244772281676 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.76231475025891 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • mRNA binding
    		•  1.71342954033223 bayes_pls_golite062009
  • DNA binding
    		•  1.62032607987786 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.09652988954158 bayes_pls_golite062009
  • transcription factor activity
    		•  0.923253759652909 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.83079633551839 bayes_pls_golite062009
  • translation regulator activity
    		•  0.82193201542158 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.803700928110921 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.662662274021266 bayes_pls_golite062009
  • signal transducer activity
    		•  0.662662274021266 bayes_pls_golite062009
  • hydrolase activity
    		•  0.42501390959416 bayes_pls_golite062009
  • importin-alpha export receptor activity
    		•  0.259676026705859 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.248585912061178 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.226380819487924 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.217517113570989 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.178770060806735 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.175241020572885 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.174922130116569 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.11022839198649 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0405268469927988 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0232727461674547 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle