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Protein Overview: BBC1

General Information:
Name(s) found: BBC1 / YJL020C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1157 amino acids

    Gene Ontology:
    Cellular Component: actin cortical patch [IDALink to PubMed articleLink to PubMed article]
    Biological Process: actin cytoskeleton organization [IGILink to PubMed article][IPILink to PubMed article]
    Molecular Function: myosin I binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEPEVPFKV VAQFPYKSDY EDDLNFEKDQ EIIVTSVEDA EWYFGEYQDS NGDVIEGIFP  60
   61 KSFVAVQGSE VGKEAESSPN TGSTEQRTIQ PEVEQKDLPE PISPETKKET LSGPVPVPAA 120
  121 TVPVPAATVP VPAATAVSAQ VQHDSSSGNG ERKVPMDSPK LKARLSMFNQ DITEQVPLPK 180
  181 STHLDLENIP VKKTIVADAP KYYVPPGIPT NDTSNLERKK SLKENEKKIV PEPINRAQVE 240
  241 SGRIETENDQ LKKDLPQMSL KERIALLQEQ QRLQAAREEE LLRKKAKLEQ EHERSAVNKN 300
  301 EPYTETEEAE ENEKTEPKPE FTPETEHNEE PQMELLAHKE ITKTSREADE GTNDIEKEQF 360
  361 LDEYTKENQK VEESQADEAR GENVAEESEI GYGHEDREGD NDEEKEEEDS EENRRAALRE 420
  421 RMAKLSGASR FGAPVGFNPF GMASGVGNKP SEEPKKKQHK EKEEEEPEQL QELPRAIPVM 480
  481 PFVDPSSNPF FRKSNLSEKN QPTETKTLDP HATTEHEQKQ EHGTHAYHNL AAVDNAHPEY 540
  541 SDHDSDEDTD DHEFEDANDG LRKHSMVEQA FQIGNNESEN VNSGEKIYPQ EPPISHRTAE 600
  601 VSHDIENSSQ NTTGNVLPVS SPQTRVARNG SINSLTKSIS GENRRKSINE YHDTVSTNSS 660
  661 ALTETAQDIS MAAPAAPVLS KVSHPEDKVP PHPVPSAPSA PPVPSAPSVP SAPPVPPAPP 720
  721 ALSAPSVPPV PPVPPVSSAP PALSAPSIPP VPPTPPAPPA PPAPLALPKH NEVEEHVKSS 780
  781 APLPPVSEEY HPMPNTAPPL PRAPPVPPAT FEFDSEPTAT HSHTAPSPPP HQNVTASTPS 840
  841 MMSTQQRVPT SVLSGAEKES RTLPPHVPSL TNRPVDSFHE SDTTPKVASI RRSTTHDVGE 900
  901 ISNNVKIEFN AQERWWINKS APPAISNLKL NFLMEIDDHF ISKRLHQKWV VRDFYFLFEN 960
  961 YSQLRFSLTF NSTSPEKTVT TLQERFPSPV ETQSARILDE YAQRFNAKVV EKSHSLINSH1020
 1021 IGAKNFVSQI VSEFKDEVIQ PIGARTFGAT ILSYKPEEGI EQLMKSLQKI KPGDILVIRK1080
 1081 AKFEAHKKIG KNEIINVGMD SAAPYSSVVT DYDFTKNKFR VIENHEGKII QNSYKLSHMK1140
 1141 SGKLKVFRIV ARGYVGW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BBC1 PPR1 SKT5 UBP7
    View Details Gavin AC, et al. (2006) BBC1 MTC1
    View Details Ho Y, et al. (2002) ADR1 BBC1 CDC39 CDC53 CPR1 CRM1 DUR1,2 ECM29 ECM33 FAA4 GAL3 GCN1 GSY2 HRT1 HTB2 HYP2 MDN1 MKT1 MMS1 MYO2 PFK1 PMA2 RPA190 RPN1 TPS1 UBI4 VPS13 YAR009C YGP1 YLR035C-A
    View Details Qiu et al. (2008) ABP1 AIP1 ARP2 BBC1 BNI1 CAP1 CAP2 COF1 CRN1 END3 LAS17 PAN1 PFY1 RVS167 SAC6 SCP1 SLA1 SRV2 TPM2 TWF1 VRP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #22 Asynchronous Prep2-IMAC Phosphopeptide enrichment B1-2 Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BBC1 Huh WK, et al. (2003)
    View Data BBC1 and SAC6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..95] PSI-BLAST 6.69897 Hemapoetic cell kinase Hck; Hemopoetic cell kinase Hck; Haemopoetic cell kinase Hck
    2 View Details [96..273] deduced N/A No confident structure predictions are available.
    3 View Details [274..454] deduced N/A No confident structure predictions are available.
    4 View Details [455..574] deduced N/A No confident structure predictions are available.
    5 View Details [575..791] deduced N/A No confident structure predictions are available.
    6 View Details [792..991] MSA 2.305994 View MSA. No confident structure predictions are available.
    7 View Details [992..1157] MSA 2.264996 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle