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Protein Overview: PPR1

General Information:
Name(s) found: PPR1 / YLR014C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 904 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [TASLink to PubMed article]
    uracil biosynthetic process [TASLink to PubMed article]
    Molecular Function: transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQKKFNSKK SNRTDLSKRG DSPNIGISKS RTACKRCRLK KIKCDQEFPS CKRCAKLEVP  60
   61 CVSLDPATGK DVPRSYVFFL EDRLAVMMRV LKEYGVDPTK IRGNIPATSD DEPFDLKKYS 120
  121 SVSSLGEEGI LPHNGLLADY LVQKGNSMAS SAITSKSMAS PQTINVQRKE FLVNSKKQDG 180
  181 SALLPETGSP MTSDARAEEL RRCNKEISAL GTMRESSFNS FLGDSSGISF AKLVFTATNF 240
  241 RQDSGDDVLD EDIKQREQKY NGYAEAENNP HFDPLELPPR HAAEVMISRF FVDTNSQLPL 300
  301 LHRELFLKKY FEPIYGPWNP NIALASDQTG INSAFEIPIT SAFSAHTEPK RENVTEKIDV 360
  361 CSSVDVPWYD TWETSQKVNM RPIVELPTKF HIPYFFLNII FAIGHATQVL KSDITTVATY 420
  421 KRRATKYIAS LFSSSDRLEA LAGTLLMVIY SIMRPNVPGV WYTMGSVLRL TVDLGLHSEK 480
  481 INKNYDAFTR EIRRRLFWCV YSLDRQICSY FGRPFGIPEE SITTRYPSLL DDSFITLTNR 540
  541 EIDDYSDLPS PNPSSKVIAL AMYKIRRIQA SIVRILYAPG AELPRRFMDL ESWRIETYNE 600
  601 LERWFQVDVP KNFEMMNCKF NSIWFDLNYH YSKSILYGLS PKFPTLNDTA FKIVLDSTKG 660
  661 TIDVFYNLCV NKKIGYTWVA VHNMFMTGMT YLYVNFYSKN NINDCQEKVS EYTEKVLIVL 720
  721 KNLIGFCESA KTCYTSYKIL SSVVIKLKFM QINDAKGIFS DSNPLTSQAN RMSSYDKKTN 780
  781 VLGFDDGTFD NKVFNRTNFE EKAPFDIPLD EFFTELEKHS NVSQFNTLDV SEGNQVINES 840
  841 ASTNTSSALN CQSYTNNQDI MDILFQVTSG SVWDEFFVRS GNGNEGESSY DISKGKNSES 900
  901 GGIF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BBC1 PPR1 SKT5 UBP7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CLB2 PPR1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..133] PSI-BLAST 533.751666 PPR1
    2 View Details [134..272] deduced N/A No confident structure predictions are available.
    3 View Details [273..618] MSA 5.104986 View MSA. No confident structure predictions are available.
    4 View Details [619..904] deduced N/A No confident structure predictions are available.
    5 View Details [537..797] MSA 3.165997 View MSA. No confident structure predictions are available.
    6 View Details [798..904] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.03201524223606 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.87955444697212 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.86200506906385 bayes_pls_golite062009
  • transcription activator activity
    		•  0.915626626047549 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.34861813464065 bayes_pls_golite062009
  • DNA binding
    		•  4.03985756894684 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.97978190843512 bayes_pls_golite062009
  • transcription factor activity
    		•  2.87348461329489 bayes_pls_golite062009
  • binding
    		•  2.82809978070212 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.80191339934741 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.67344049333457 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.50774349911815 bayes_pls_golite062009
  • transcription activator activity
    		•  0.822069987038721 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle