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View Structure Prediction Details

Protein: PPR1
Organism: Saccharomyces cerevisiae
Length: 904 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPR1.

Description E-value Query
Range
Subject
Range
PPR1_YEAST - Pyrimidine pathway regulatory protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
PPR1 - Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regu...
0.0 [1..904] [1..904]
ACU15_NEUCR - Transcriptional activator protein acu-15 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS ...
ACU15_NEUCR, AC1... - Transcriptional activator protein acu-15 OS=Neurospora crassa GN=acu-15 PE=1 SV=2, (P87000) Transcri...
8.0E-82 [12..788] [2..654]
gi|166488 - gi|166488|gb|AAA32686.1| regulatory protein
9.0E-82 [16..804] [1..676]
gi|6901427 - gi|6901427|emb|CAB71797.1| pathway-specific nitrogen regulator [Tolypocladium inflatum]
1.0E-80 [6..779] [42..701]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-76 [18..800] [23..693]
THI1_SCHPO - Thiamine repressible genes regulatory protein thi1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 2...
thi1 - transcription factor Thi1
3.0E-76 [18..800] [23..693]
NIRA_EMENI - Nitrogen assimilation transcription factor nirA OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 ...
NIRA_EMENI - Nitrogen assimilation transcription factor nirA OS=Emericella nidulans GN=nirA PE=4 SV=1
1.0E-73 [8..760] [16..636]

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Predicted Domain #1
Region A:
Residues: [1-133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQKKFNSKK SNRTDLSKRG DSPNIGISKS RTACKRCRLK KIKCDQEFPS CKRCAKLEVP  60
   61 CVSLDPATGK DVPRSYVFFL EDRLAVMMRV LKEYGVDPTK IRGNIPATSD DEPFDLKKYS 120
  121 SVSSLGEEGI LPH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 533.751666
Match: 1pyiA_
Description: PPR1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56444258780502 bayes_pls_golite062009
DNA binding 4.26146437716972 bayes_pls_golite062009
nucleic acid binding 4.17369933547911 bayes_pls_golite062009
transcription factor activity 3.049435548132 bayes_pls_golite062009
binding 2.91929847152301 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.03201524223606 bayes_pls_golite062009
sequence-specific DNA binding 1.87955444697212 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.86200506906385 bayes_pls_golite062009
transcription activator activity 0.915626626047549 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [134-272]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGLLADYLVQ KGNSMASSAI TSKSMASPQT INVQRKEFLV NSKKQDGSAL LPETGSPMTS  60
   61 DARAEELRRC NKEISALGTM RESSFNSFLG DSSGISFAKL VFTATNFRQD SGDDVLDEDI 120
  121 KQREQKYNGY AEAENNPHF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.34861813464065 bayes_pls_golite062009
DNA binding 4.03985756894684 bayes_pls_golite062009
nucleic acid binding 3.97978190843512 bayes_pls_golite062009
transcription factor activity 2.87348461329489 bayes_pls_golite062009
binding 2.82809978070212 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.80191339934741 bayes_pls_golite062009
sequence-specific DNA binding 1.67344049333457 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.50774349911815 bayes_pls_golite062009
transcription activator activity 0.822069987038721 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [273-618]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPLELPPRHA AEVMISRFFV DTNSQLPLLH RELFLKKYFE PIYGPWNPNI ALASDQTGIN  60
   61 SAFEIPITSA FSAHTEPKRE NVTEKIDVCS SVDVPWYDTW ETSQKVNMRP IVELPTKFHI 120
  121 PYFFLNIIFA IGHATQVLKS DITTVATYKR RATKYIASLF SSSDRLEALA GTLLMVIYSI 180
  181 MRPNVPGVWY TMGSVLRLTV DLGLHSEKIN KNYDAFTREI RRRLFWCVYS LDRQICSYFG 240
  241 RPFGIPEESI TTRYPSLLDD SFITLTNREI DDYSDLPSPN PSSKVIALAM YKIRRIQASI 300
  301 VRILYAPGAE LPRRFMDLES WRIETYNELE RWFQVDVPKN FEMMNC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [619-904]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFNSIWFDLN YHYSKSILYG LSPKFPTLND TAFKIVLDST KGTIDVFYNL CVNKKIGYTW  60
   61 VAVHNMFMTG MTYLYVNFYS KNNINDCQEK VSEYTEKVLI VLKNLIGFCE SAKTCYTSYK 120
  121 ILSSVVIKLK FMQINDAKGI FSDSNPLTSQ ANRMSSYDKK TNVLGFDDGT FDNKVFNRTN 180
  181 FEEKAPFDIP LDEFFTELEK HSNVSQFNTL DVSEGNQVIN ESASTNTSSA LNCQSYTNNQ 240
  241 DIMDILFQVT SGSVWDEFFV RSGNGNEGES SYDISKGKNS ESGGIF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [537-797]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTNREIDDYS DLPSPNPSSK VIALAMYKIR RIQASIVRIL YAPGAELPRR FMDLESWRIE  60
   61 TYNELERWFQ VDVPKNFEMM NCKFNSIWFD LNYHYSKSIL YGLSPKFPTL NDTAFKIVLD 120
  121 STKGTIDVFY NLCVNKKIGY TWVAVHNMFM TGMTYLYVNF YSKNNINDCQ EKVSEYTEKV 180
  181 LIVLKNLIGF CESAKTCYTS YKILSSVVIK LKFMQINDAK GIFSDSNPLT SQANRMSSYD 240
  241 KKTNVLGFDD GTFDNKVFNR T

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [798-904]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFEEKAPFDI PLDEFFTELE KHSNVSQFNT LDVSEGNQVI NESASTNTSS ALNCQSYTNN  60
   61 QDIMDILFQV TSGSVWDEFF VRSGNGNEGE SSYDISKGKN SESGGIF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle