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View Structure Prediction Details

Protein: CRM1
Organism: Saccharomyces cerevisiae
Length: 1084 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CRM1.

Description E-value Query
Range		 Subject
Range
gi|5690335 - gi|5690335|gb|AAD47043.1|AF158021_1 CRM1/XPO1 protein [Xenopus laevis]
 0.0 [3..1084] [15..1067]
XPO1 - exportin 1 (CRM1 homolog, yeast)
gi|109103010, gi... - gi|109103012|ref|XP_001115623.1| PREDICTED: similar to exportin 1 isoform 3 [Macaca mulatta], gi|109...
gi|208967809, gi... - gi|208967809|dbj|BAG72550.1| exportin 1 [synthetic construct], gi|123980736|gb|ABM82197.1| exportin ...
 0.0 [3..1084] [15..1067]
gi|190406773 - gi|190406773|gb|EDV10040.1| chromosome region maintenance protein [Saccharomyces cerevisiae RM11-1a]
CRM1 - Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; ex...
XPO1_YEAST - Exportin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CRM1 PE=1 SV=1
gi|151943495 - gi|151943495|gb|EDN61806.1| chromosome region maintenance protein [Saccharomyces cerevisiae YJM789]
 0.0 [1..1084] [1..1084]
gi|14250864 - gi|14250864|emb|CAC39223.1| exportin 1b [Arabidopsis thaliana]
 0.0 [2..1084] [4..1071]
gi|11493965 - gi|11493965|gb|AAG35722.1| crm1 protein [Schizosaccharomyces pombe]
 0.0 [1..1083] [1..1071]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [1..1083] [1..1071]
gi|5734611 - gi|5734611|dbj|BAA83347.1| Crm1-K1 [synthetic construct]
 0.0 [1..1083] [1..1071]

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Predicted Domain #1
Region A:
Residues: [1-746] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK ADQILQFSTN  60
   61 PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS MCQDDEVFKT QKNLINKSDL 120
  121 TLVQILKQEW PQNWPEFIPE LIGSSSSSVN VCENNMIVLK LLSEEVFDFS AEQMTQAKAL 180
  181 HLKNSMSKEF EQIFKLCFQV LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST 240
  241 KFMTSPDTRA ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT 300
  301 YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL SKIEERELFK 360
  361 TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST GSGALNPEYM KRFPLKKHIY 420
  421 EEICSQLRLV IIENMVRPEE VLVVENDEGE IVREFVKESD TIQLYKSERE VLVYLTHLNV 480
  481 IDTEEIMISK LARQIDGSEW SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV 540
  541 KKRGKDNKAV VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI 600
  601 KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI IISEERSVAE 660
  661 RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA NIIKTNVAVC TSMGADFYPQ 720
  721 LGHIYYNMLQ LYRAVSSMIS AQVAAE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
nuclear export signal receptor activity 3.48172991171337 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
structural molecule activity 2.87774614675757 bayes_pls_golite062009
protein transmembrane transporter activity 2.74547353635661 bayes_pls_golite062009
cytoskeletal protein binding 2.61566088685247 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
nucleic acid binding 2.34284977509828 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
signal sequence binding 2.11631489628537 bayes_pls_golite062009
RNA binding 1.98024495780436 bayes_pls_golite062009
nuclear localization sequence binding 1.91487015967262 bayes_pls_golite062009
actin binding 1.76244772281676 bayes_pls_golite062009
transcription regulator activity 1.76231475025891 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
mRNA binding 1.71342954033223 bayes_pls_golite062009
DNA binding 1.62032607987786 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
transcription factor activity 0.923253759652909 bayes_pls_golite062009
translation initiation factor activity 0.83079633551839 bayes_pls_golite062009
translation regulator activity 0.82193201542158 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.803700928110921 bayes_pls_golite062009
molecular transducer activity 0.662662274021266 bayes_pls_golite062009
signal transducer activity 0.662662274021266 bayes_pls_golite062009
hydrolase activity 0.42501390959416 bayes_pls_golite062009
importin-alpha export receptor activity 0.259676026705859 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
protein phosphatase binding 0.11022839198649 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009
transcription activator activity 0.0232727461674547 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [747-848] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLIATKTPKV RGLRTIKKEI LKLVETYISK ARNLDDVVKV LVEPLLNAVL EDYMNNVPDA  60
   61 RDAEVLNCMT TVVEKVGHMI PQGVILILQS VFECTLDMIN KD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.891 0.871 protein transmembrane transporter activity a.118.1 ARM repeat

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
nuclear export signal receptor activity 3.48172991171337 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
structural molecule activity 2.87774614675757 bayes_pls_golite062009
protein transmembrane transporter activity 2.74547353635661 bayes_pls_golite062009
cytoskeletal protein binding 2.61566088685247 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
nucleic acid binding 2.34284977509828 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
signal sequence binding 2.11631489628537 bayes_pls_golite062009
RNA binding 1.98024495780436 bayes_pls_golite062009
nuclear localization sequence binding 1.91487015967262 bayes_pls_golite062009
actin binding 1.76244772281676 bayes_pls_golite062009
transcription regulator activity 1.76231475025891 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
mRNA binding 1.71342954033223 bayes_pls_golite062009
DNA binding 1.62032607987786 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
transcription factor activity 0.923253759652909 bayes_pls_golite062009
translation initiation factor activity 0.83079633551839 bayes_pls_golite062009
translation regulator activity 0.82193201542158 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.803700928110921 bayes_pls_golite062009
molecular transducer activity 0.662662274021266 bayes_pls_golite062009
signal transducer activity 0.662662274021266 bayes_pls_golite062009
hydrolase activity 0.42501390959416 bayes_pls_golite062009
importin-alpha export receptor activity 0.259676026705859 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
protein phosphatase binding 0.11022839198649 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009
transcription activator activity 0.0232727461674547 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [849-946] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTEYPEHRVE FYKLLKVINE KSFAAFLELP PAAFKLFVDA ICWAFKHNNR DVEVNGLQIA  60
   61 LDLVKNIERM GNVPFANEFH KNYFFIFVSE TFFVLTDS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.41
Match: 1c7dA
Description: Hemoglobin, alpha-chain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [947-1084] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHKSGFSKQA LLLMKLISLV YDNKISVPLY QEAEVPQGTS NQVYLSQYLA NMLSNAFPHL  60
   61 TSEQIASFLS ALTKQYKDLV VFKGTLRDFL VQIKEVGGDP TDYLFAEDKE NALMEQNRLE 120
  121 REKAAKIGGL LKPSELDD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.41
Match: 1c7dA
Description: Hemoglobin, alpha-chain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle