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Protein Overview: LCB1

General Information:
Name(s) found: LCB1 / YMR296C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 558 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    microsome [IPILink to PubMed article]
    serine C-palmitoyltransferase complex [IMPLink to PubMed article]
    Biological Process: sphingolipid biosynthetic process [TASLink to PubMed article]
    Molecular Function: serine C-palmitoyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAHIPEVLPK SIPIPAFIVT TSSYLWYYFN LVLTQIPGGQ FIVSYIKKSH HDDPYRTTVE  60
   61 IGLILYGIIY YLSKPQQKKS LQAQKPNLSP QEIDALIEDW EPEPLVDPSA TDEQSWRVAK 120
  121 TPVTMEMPIQ NHITITRNNL QEKYTNVFNL ASNNFLQLSA TEPVKEVVKT TIKNYGVGAC 180
  181 GPAGFYGNQD VHYTLEYDLA QFFGTQGSVL YGQDFCAAPS VLPAFTKRGD VIVADDQVSL 240
  241 PVQNALQLSR STVYYFNHND MNSLECLLNE LTEQEKLEKL PAIPRKFIVT EGIFHNSGDL 300
  301 APLPELTKLK NKYKFRLFVD ETFSIGVLGA TGRGLSEHFN MDRATAIDIT VGSMATALGS 360
  361 TGGFVLGDSV MCLHQRIGSN AYCFSACLPA YTVTSVSKVL KLMDSNNDAV QTLQKLSKSL 420
  421 HDSFASDDSL RSYVIVTSSP VSAVLHLQLT PAYRSRKFGY TCEQLFETMS ALQKKSQTNK 480
  481 FIEPYEEEEK FLQSIVDHAL INYNVLITRN TIVLKQETLP IVPSLKICCN AAMSPEELKN 540
  541 ACESVKQSIL ACCQESNK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) LCB1 LCB2
    View Details Gavin AC, et al. (2006) LCB1 LCB2
    View Details Gavin AC, et al. (2002) BMH1 BMH2 CLU1 CRM1 ECM29 FKS1 GCN1 GEA2 GFA1 HRP1 KAP104 KAP123 LCB1 LCB2 LYS12 MIR1 NAB2 SAM1 SAM2 YHR020W
    View Details Qiu et al. (2008) FEN1 GPI11 GWT1 LCB1 LCB2 LIP1 PIS1 SUR4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data LCB1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] deduced N/A No confident structure predictions are available.
    2 View Details [86..153]
    [412..558]    		 PSI-BLAST 309.741366 2-amino-3-ketobutyrate CoA ligase
    3 View Details [154..411] PSI-BLAST 309.741366 2-amino-3-ketobutyrate CoA ligase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.33

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle