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Protein Overview: KAP122

General Information:
Name(s) found: KAP122 / YGL016W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1081 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    nuclear pore [IDALink to PubMed article]
    Biological Process: protein import into nucleus [IDALink to PubMed article]
    response to drug [TASLink to PubMed article]
    regulation of cell size [IMPLink to PubMed article]
    Molecular Function: protein transmembrane transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSIHEVVAL IEELYSPHPK HDVNQIQQSL QSIQKSEQGF HLANELLSDD KYSANVKYFG  60
   61 ALTLTVQLNT RGENDYETLW NVFRSNLLYL TKFSTLYVSN PNMYGQSLII IKKLMSNLSL 120
  121 IFTKINDPQL NNAGNENMIK QWNNPINTFI QLMSVQNQNI NADQLLLDSI NCSLTYEQLS 180
  181 QFVSLSQKHN ELALTFTEVI VEDLTKFQTK RHSMSQIHEV VHEHLYISTM ALINLNLTAQ 240
  241 AVFNPTVFDC ITAWINYISL TRSVSSSGRM DLSEIFQNLI DLMYQSTEGS DGYENAEKIL 300
  301 TIFGNVFAND PLLMSYDLRQ QIECIFLGVV RPDSGITDIS NKNSWMLQYM NYLVTNDFFS 360
  361 ELKELAICIV DFLQINTLSV CNKLFTNIQA ADNGQVQDEY IQEYIKVLLQ MTNFPLTPVL 420
  421 QEFFSVRMVD FWLDLSDAYT NLASETLRPN SIELSTQIFQ QLINIYLPKI SLSVKQRIIE 480
  481 EEGESTSVNE FEDFRNAVSD LAQSLWSILG NDNLTNVLID GMGQMPAASD ETLIIKDTDV 540
  541 LFRIETMCFV LNTILVDMTL SESPWIKNIV DANKFFNQNV ISVFQTGFQT SASTKVSQIL 600
  601 KLDFVRTSTT LIGTLAGYFK QEPFQLNPYV EALFQGLHTC TNFTSKNEQE KISNDKLEVM 660
  661 VIKTVSTLCE TCREELTPYL MHFISFLNTV IMPDSNVSHF TRTKLVRSIG YVVQCQVSNG 720
  721 PEEQAKYILQ LTNLLSGSIE HCLASSVQLQ EQQDYINCLL YCISELATSL IQPTEIIEND 780
  781 ALLQRLSEFQ SFWSSDPLQI RSKIMCTIDK VLDNSIYCKN SAFVEIGCLI VGKGLNLPDG 840
  841 EPYFLKYNMS EVMNFVLRHV PNCELATCLP YFVYLLEKLI SEFRKELTPQ EFDFMFEKIL 900
  901 LVYYDAYIIN DPDLLQMTIG FVNNVLDVKP GLAIGSKHWT SFILPQFLKL IPSREKFTIV 960
  961 AVAKFWTKLI NNKKYNQEEL TTVRQQVSSI GGDLVYQIMY GLFHTQRSDL NSYTDLLRAL1020
 1021 VAKFPIEARE WLVAVLPQIC NNPAGHEKFI NKLLITRGSR AAGNVILQWW LDCTTLPNYQ1080
 1081 G

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE8 CHZ1 ECM2 HCR1 HEM12 KAP122 NIP1 PRT1 RPG1 SUI1 SYH1 TIF34 TIF35 TIF5 YOR052C
    View Details Ho Y, et al. (2002) ADR1 ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 ATG12 BNI1 CRM1 DOP1 DUR1,2 ECM29 FET3 IMH1 KAP122 KGD1 MCM4 MCM7 MET10 MET18 PFK1 RPA135 RPA190 RPC40 RPN1 RPO31 RPT4 SRY1 TRP3 YER138C YJR029W
    View Details Qiu et al. (2008) KAP122 KAP123 KAP95 MIP6 MLP2 NUP1 POM152

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 control 2 McCusker D, et al (2007)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data KAP122 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..393] deduced N/A No confident structure predictions are available.
    2 View Details [394..1081] MSA 2.014875 View MSA. No confident structure predictions are available.
    3 View Details [929..1081] MSA 2.079965 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  4.20717321392127 bayes_pls_golite062009
  • binding
    		•  2.76236644111948 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.41503596785122 bayes_pls_golite062009
  • transporter activity
    		•  2.3766833486706 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.12926593993985 bayes_pls_golite062009
  • protein binding
    		•  1.5114863464349 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  1.4950300017044 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.2724388835449 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.04982314606251 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  0.86012890098627 bayes_pls_golite062009
  • RNA binding
    		•  0.821282292359571 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.753616504399234 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.462279025397785 bayes_pls_golite062009
  • signal transducer activity
    		•  0.462279025397785 bayes_pls_golite062009
  • signal sequence binding
    		•  0.279693431859311 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.260663498540354 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.256036243669218 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.234271600707329 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.225395946682209 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.186601655036333 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.183072614802483 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.182751938544977 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.147335771550418 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.109435859778099 bayes_pls_golite062009
  • DNA binding
    		•  0.0985062788532622 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0728493557966827 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0641324729536009 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0615190129942244 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0475280280823402 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle