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Protein Overview: SEH1

General Information:
Name(s) found: SEH1 / YGL100W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 349 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [TASLink to PubMed article]
    rRNA export from nucleus [TASLink to PubMed article]
    nuclear pore organization [TASLink to PubMed article]
    snRNP protein import into nucleus [TASLink to PubMed article]
    mRNA-binding (hnRNP) protein import into nucleus [TASLink to PubMed article]
    snRNA export from nucleus [TASLink to PubMed article]
    tRNA export from nucleus [TASLink to PubMed article]
    NLS-bearing substrate import into nucleus [TASLink to PubMed article]
    protein export from nucleus [TASLink to PubMed article]
    ribosomal protein import into nucleus [TASLink to PubMed article]
    Molecular Function: structural molecule activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPFDSGHDD LVHDVVYDFY GRHVATCSSD QHIKVFKLDK DTSNWELSDS WRAHDSSIVA  60
   61 IDWASPEYGR IIASASYDKT VKLWEEDPDQ EECSGRRWNK LCTLNDSKGS LYSVKFAPAH 120
  121 LGLKLACLGN DGILRLYDAL EPSDLRSWTL TSEMKVLSIP PANHLQSDFC LSWCPSRFSP 180
  181 EKLAVSALEQ AIIYQRGKDG KLHVAAKLPG HKSLIRSISW APSIGRWYQL IATGCKDGRI 240
  241 RIFKITEKLS PLASEESLTN SNMFDNSADV DMDAQGRSDS NTEEKAELQS NLQVELLSEH 300
  301 DDHNGEVWSV SWNLTGTILS SAGDDGKVRL WKATYSNEFK CMSVITAQQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NUP120 NUP145 NUP84 NUP85 SEC13 SEH1
    View Details (MIPS) Mewes HW, et al. (2004) NUP120 NUP145 NUP84 NUP85 SEC13 SEH1
    View Details Krogan NJ, et al. (2006) MEX67 NUP120 NUP145 NUP84 NUP85 SEH1
    View Details Gavin AC, et al. (2006) NUP120 NUP145 NUP84 NUP85 SEC13 SEH1
    View Details Gavin AC, et al. (2002) CKA1 CKA2 CKB1 COP1 DBP2 ERO1 GLO3 GPT2 ILV1 MRPS28 NUP120 NUP145 NUP84 NUP85 OST1 OST6 PGK1 RET2 RET3 RPP2B SAM1 SCJ1 SEC13 SEC16 SEC21 SEC23 SEC26 SEC27 SEC28 SEC31 SEH1 STM1 STT3 SWP1 TIF34 TOS1 WBP1
    View Details Ho Y, et al. (2002) ADE13 APE3 BMS1 CBP3 CCT6 CDC33 CDC53 CIC1 COF1 CPR6 CTF4 DBP10 DED81 DIA2 ENP1 FMP10 FPR3 HEM15 ILS1 KRE33 KRI1 LST4 MCM2 MCM3 MCM5 MDJ1 MTC5 NIP7 NMD3 NOP12 NPR2 NUP145 NUP84 NUP85 POX1 RNQ1 RRP12 SEC13 SEH1 SKP1 SLT2 SPB1 SSF1 SSF2 SSZ1 THI21 TIF6 URB1 UTP10 YAK1 YBL104C YHR033W YMR209C
    View Details Qiu et al. (2008) MEX67 NDC1 NSP1 NUP116 NUP120 NUP133 NUP145 NUP188 NUP42 NUP49 NUP53 NUP57 NUP85 POM152 SEC13 SEH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..349] PSI-BLAST 95.612477 Tup1, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.2778252170547 bayes_pls_golite062009
  • snoRNA binding
    		•  1.61553185503007 bayes_pls_golite062009
  • protein binding
    		•  1.24173112731149 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • protein transporter activity
    		•  0.964340340346761 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.693814013902061 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.359536347486199 bayes_pls_golite062009
  • receptor activity
    		•  0.314900439093911 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.190100099674138 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.168317261786777 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.132660456600365 bayes_pls_golite062009
  • kinase activity
    		•  0.127621956173205 bayes_pls_golite062009
    		• 0.0248988265652406 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle