Protein Overview: NUP49

General Information:
Name(s) found:	NUP49 / YGL172W [SGD]
Description(s) found: Found 28 descriptions. SHOW ALL	Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes [SGD]
Organism:	Saccharomyces cerevisiae
Length:	472 amino acids
Gene Ontology:
Cellular Component:	nuclear envelope [IDA] nuclear pore [IDA]
Biological Process:	tRNA splicing, via endonucleolytic cleavage and ligation [IMP] protein export from nucleus [TAS] ribosomal protein import into nucleus [TAS] mRNA export from nucleus [IMP] ribosomal large subunit export from nucleus [IMP] rRNA export from nucleus [TAS] nuclear pore organization [TAS] snRNP protein import into nucleus [TAS] mRNA-binding (hnRNP) protein import into nucleus [TAS] snRNA export from nucleus [TAS] protein import into nucleus [IMP] tRNA export from nucleus [TAS] NLS-bearing substrate import into nucleus [TAS]
Molecular Function:	structural molecule activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFGLNKASST PAGGLFGQAS GASTGNANTG FSFGGTQTGQ NTGPSTGGLF GAKPAGSTGG  60
   61 LGASFGQQQQ QSQTNAFGGS ATTGGGLFGN KPNNTANTGG GLFGANSNSN SGSLFGSNNA 120
  121 QTSRGLFGNN NTNNINNSSS GMNNASAGLF GSKPAGGTSL FGNTSTSSAP AQNQGMFGAK 180
  181 PAGTSLFGNN AGNTTTGGGL FGSKPTGATS LFGSSNNNNN NNNSNNIMSA SGGLFGNQQQ 240
  241 QLQQQPQMQC ALQNLSQLPI TPMTRISELP PQIRQEIEQL DQYIQKQVQI SHHLKADTID 300
  301 HDELIDSIPR DVAYLLKSES ATSQYLKQDL KKISSFKSLI DEDLLDTQTF SVLLQQLLTP 360
  361 GSKISSNDLD KFFQKKIHLY EKKLEDYCRI LSDIETAVNG IDTDLFGAPN NPNSTAITAD 420
  421 LGSSEAENLL QLKTGLAAIV STVIEEFTLF MDIAERIAVL HQKTKTLASL SI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		NUP49 NUP57
View Details	(MIPS) Mewes HW, et al. (2004)		NIC96 NSP1 NUP49 NUP57
View Details	Krogan NJ, et al. (2006)		NIC96 NUP49 NUP57
View Details	Qiu et al. (2008)		ASM4 GLE2 NDC1 NIC96 NSP1 NUP1 NUP100 NUP116 NUP145 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 NUP49 NUP53 NUP57 NUP82 NUP84 POM152 SEC13 SEH1 SUS1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SPP382	NUP49	2	Hazbun TR, et al. (2003)
View Screen	PRE8	NUP49	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	NUP49	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..238]	PSI-BLAST	5.0	Fibrinogen
2	View Details	[239..390] [448..472]	ORFEUS	8.31	Syntaxin 1A N-terminal domain
3	View Details	[391..447]	ORFEUS	8.31	Syntaxin 1A N-terminal domain

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2