YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: NUP133

General Information:
Name(s) found: NUP133 / YKR082W [SGD]
Description(s) found:
Found 28 descriptions.
SHOW ALL
  • Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1157 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [IMPLink to PubMed article]
    rRNA export from nucleus [TASLink to PubMed article]
    nuclear pore organization [IMPLink to PubMed article]
    snRNP protein import into nucleus [TASLink to PubMed article]
    mRNA-binding (hnRNP) protein import into nucleus [TASLink to PubMed article]
    snRNA export from nucleus [TASLink to PubMed article]
    chromosome localization [IMPLink to PubMed article]
    tRNA export from nucleus [TASLink to PubMed article]
    NLS-bearing substrate import into nucleus [TASLink to PubMed article]
    DNA metabolic process [IGILink to PubMed article]
    protein export from nucleus [TASLink to PubMed article]
    ribosomal protein import into nucleus [TASLink to PubMed article]
    Molecular Function: structural molecule activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEKKVHLRL RKELSVPIAV VENESLAQLS YEEESQASLM DISMEQQQLR LHSHFDNSKV  60
   61 FTENNRYIVK TLQTDYSSGF SNDDELNGYI DMQIGYGLVN DHKKVYIWNI HSTQKDTPYI 120
  121 TVPFRSDDND EIAVAPRCIL TFPATMDESP LALNPNDQDE TGGLIIIKGS KAIYYEDINS 180
  181 INNLNFKLSE KFSHELELPI NSSGGEKCDL MLNCEPAGIV LSTNMGRIFF ITIRNSMGKP 240
  241 QLKLGKLLNK PFKLGIWSKI FNTNSSVVSL RNGPILGKGT RLVYITTNKG IFQTWQLSAT 300
  301 NSHPTKLIDV NIYEAILESL QDLYPFAHGT LKIWDSHPLQ DESSQLFLSS IYDSSCNETY 360
  361 YILSTIIFDS SSNSFTIFST YRLNTFMESI TDTKFKPKIF IPQMENANDT NEVTSILVMF 420
  421 PNAVVITQVN SKLDSSYSMR RKWEDIVSLR NDIDIIGSGY DSKSLYVLTK QMGVLQFFVK 480
  481 ENEETNSKPE VGFVKSHVDQ AVYFSKINAN PIDFNLPPEI SLDQESIEHD LKLTSEEIFH 540
  541 SNGKYIPPML NTLGQHLSVR KEFFQNFLTF VAKNFNYKIS PELKLDLIEK FEILNCCIKF 600
  601 NSIIRQSDVL NDIWEKTLSN YNLTQNEHLT TKTVVINSPD VFPVIFKQFL NHVVFVLFPS 660
  661 QNQNFKLNVT NLINLCFYDG ILEEGEKTIR YELLELDPME VDTSKLPWFI NFDYLNCINQ 720
  721 CFFDFTFACE EEGSLDSYKE GLLKIVKILY YQFNQFKIWI NTQPVKSVNA NDNFININNL 780
  781 YDDNHLDWNH VLCKVNLKEQ CIQIAEFYKD LSGLVQTLQT LDQNDSTTVS LYETFFNEFP 840
  841 KEFSFTLFEY LIKHKKLNDL IFRFPQQHDV LIQFFQESAP KYGHVAWIQQ ILDGSYADAM 900
  901 NTLKNITVDD SKKGESLSEC ELHLNVAKLS SLLVEKDNLD INTLRKIQYN LDTIDAEKNI 960
  961 SNKLKKGEVQ ICKRFKNGSI REVFNILVEE LKSTTVVNLS DLVELYSMLD DEESLFIPLR1020
 1021 LLSVDGNLLN FEVKKFLNAL VWRRIVLLNA SNEGDKLLQH IVKRVFDEEL PKNNDFPLPS1080
 1081 VDLLCDKSLL TPEYISETYG RFPIDQNAIR EEIYEEISQV ETLNSDNSLE IKLHSTIGSV1140
 1141 AKEKNYTINY ETNTVEY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) GLE2 NOP14 NUP1 NUP100 NUP116 NUP133 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 POM152
    View Details Krogan NJ, et al. (2006) NSP1 NUP133 NUP159 NUP82
    View Details Ho Y, et al. (2002) NUP133 SEC13 SEC31 YHL039W
    View Details Qiu et al. (2008) ASM4 DBP5 GLE2 KAP120 NDC1 NIC96 NSP1 NUP1 NUP100 NUP116 NUP120 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188 NUP192 NUP2 NUP42 NUP53 NUP57 NUP82 NUP84 NUP85 POM152 SEH1 SUS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NUP133 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..607] FFAS03 6.44 The crystal structure of the N-terminal domain of Nup133 reveals a beta-propeller fold common to several nucleoporins
    2 View Details [608..769] deduced N/A No confident structure predictions are available.
    3 View Details [770..924] MSA 2.042996 View MSA. No confident structure predictions are available.
    4 View Details [925..1074] MSA 1.040977 View MSA. No confident structure predictions are available.
    5 View Details [1075..1157] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.73

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle