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Protein Overview: POX1

General Information:
Name(s) found: POX1 / YGL205W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 748 amino acids

    Gene Ontology:
    Cellular Component: peroxisomal matrix [TAS]
    Biological Process: fatty acid beta-oxidation [TAS]
    Molecular Function: acyl-CoA oxidase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRRTTINPD SVVLNPQKFI QKERADSKIK VDQVNTFLES SPERRTLTHA LIDQIVNDPI  60
   61 LKTDTDYYDA KKMQEREITA KKIARLASYM EHDIKTVRKH FRDTDLMKEL QANDPDKASP 120
  121 LTNKDLFIFD KRLSLVANID PQLGTRVGVH LGLFGNCIKG NGTDEQIRYW LQERGATLMK 180
  181 GIYGCFAMTE LGHGSNVAQL QTRAVYDKQN DTFVIDTPDL TATKWWIGGA AHSATHAAVY 240
  241 ARLIVEGKDY GVKTFVVPLR DPSTFQLLAG VSIGDIGAKM GRDGIDNGWI QFRNVVIPRE 300
  301 FMLSRFTKVV RSPDGSVTVK TEPQLDQISG YSALLSGRVN MVMDSFRFGS KFATIAVRYA 360
  361 VGRQQFAPRK GLSETQLIDY PLHQYRVLPQ LCVPYLVSPV AFKLMDNYYS TLDELYNASS 420
  421 SAYKAALVTV SKKLKNLFID SASLKATNTW LIATLIDELR QTCGGHGYSQ YNGFGKGYDD 480
  481 WVVQCTWEGD NNVLSLTSAK SILKKFIDSA TKGRFDNTLD VDSFSYLKPQ YIGSVVSGEI 540
  541 KSGLKELGDY TEIWSITLIK LLAHIGTLVE KSRSIDSVSK LLVLVSKFHA LRCMLKTYYD 600
  601 KLNSRDSHIS DEITKESMWN VYKLFSLYFI DKHSGEFQQF KIFTPDQISK VVQPQLLALL 660
  661 PIVRKDCIGL TDSFELPDAM LNSPIGYFDG DIYHNYFNEV CRNNPVEADG AGKPSYHALL 720
  721 SSMLGRGFEF DQKLGGAANA EILSKINK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CCT6 CDC33 CPR6 FMP10 MDJ1 MTC5 NPR2 POX1 RNQ1 SEH1 THI21 YHR033W
    View Details Qiu et al. (2008) CAT2 DCI1 FOX2 MDH3 PEX11 POT1 POX1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen IMP4 POX1 2 Unpublished Fields Lab Data
    View Screen ZIM17 POX1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..45]
    [329..748]    		 PSI-BLAST 917.228787 Peroxisomal acyl-CoA oxidase-II, domains 3 and 4; Peroxisomal acyl-CoA oxidase-II, domains 1 and 2
    2 View Details [46..328] PSI-BLAST 917.228787 Peroxisomal acyl-CoA oxidase-II, domains 3 and 4; Peroxisomal acyl-CoA oxidase-II, domains 1 and 2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acyl-CoA oxidase activity
    		•  7.85164875699474 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  7.69964776555327 bayes_pls_golite062009
  • acyl-CoA dehydrogenase activity
    		•  6.0252876667118 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
    		•  5.50948952617422 bayes_pls_golite062009
  • palmitoyl-CoA oxidase activity
    		•  5.41720462605663 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.99827953439804 bayes_pls_golite062009
  • catalytic activity
    		•  2.41506805547596 bayes_pls_golite062009
  • pristanoyl-CoA oxidase activity
    		•  2.26651221125135 bayes_pls_golite062009
  • binding
    		•  0.749242681954192 bayes_pls_golite062009
  • protein binding
    		•  0.269787458920778 bayes_pls_golite062009
  • long-chain-acyl-CoA dehydrogenase activity
    		•  0.13696326544237 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle