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Protein Overview: FOX2

General Information:
Name(s) found: FOX2 / YKR009C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 900 amino acids

    Gene Ontology:
    Cellular Component: peroxisomal matrix [TAS]
    Biological Process: fatty acid beta-oxidation [TAS]
    Molecular Function: 3-hydroxyacyl-CoA dehydrogenase activity [TAS]
    enoyl-CoA hydratase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGNLSFKDR VVVITGAGGG LGKVYALAYA SRGAKVVVND LGGTLGGSGH NSKAADLVVD  60
   61 EIKKAGGIAV ANYDSVNENG EKIIETAIKE FGRVDVLINN AGILRDVSFA KMTEREFASV 120
  121 VDVHLTGGYK LSRAAWPYMR SQKFGRIINT ASPAGLFGNF GQANYSAAKM GLVGLAETLA 180
  181 KEGAKYNINV NSIAPLARSR MTENVLPPHI LKQLGPEKIV PLVLYLTHES TKVSNSIFEL 240
  241 AAGFFGQLRW ERSSGQIFNP DPKTYTPEAI LNKWKEITDY RDKPFNKTQH PYQLSDYNDL 300
  301 ITKAKKLPPN EQGSVKIKSL CNKVVVVTGA GGGLGKSHAI WFARYGAKVV VNDIKDPFSV 360
  361 VEEINKLYGE GTAIPDSHDV VTEAPLIIQT AISKFQRVDI LVNNAGILRD KSFLKMKDEE 420
  421 WFAVLKVHLF STFSLSKAVW PIFTKQKSGF IINTTSTSGI YGNFGQANYA AAKAAILGFS 480
  481 KTIALEGAKR GIIVNVIAPH AETAMTKTIF SEKELSNHFD ASQVSPLVVL LASEELQKYS 540
  541 GRRVIGQLFE VGGGWCGQTR WQRSSGYVSI KETIEPEEIK ENWNHITDFS RNTINPSSTE 600
  601 ESSMATLQAV QKAHSSKELD DGLFKYTTKD CILYNLGLGC TSKELKYTYE NDPDFQVLPT 660
  661 FAVIPFMQAT ATLAMDNLVD NFNYAMLLHG EQYFKLCTPT MPSNGTLKTL AKPLQVLDKN 720
  721 GKAALVVGGF ETYDIKTKKL IAYNEGSFFI RGAHVPPEKE VRDGKRAKFA VQNFEVPHGK 780
  781 VPDFEAEIST NKDQAALYRL SGDFNPLHID PTLAKAVKFP TPILHGLCTL GISAKALFEH 840
  841 YGPYEELKVR FTNVVFPGDT LKVKAWKQGS VVVFQTIDTT RNVIVLDNAA VKLSQAKSKL 900
  901

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CYK3 FOX2
    View Details Qiu et al. (2008) DCI1 FOX2 MDH3 POT1 POX1 SPS19 TES1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run HIR2 No Comments Green EM, et al (2005)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..258] PSI-BLAST 17.221849 Enoyl-ACP reductase
    2 View Details [259..314] deduced N/A No confident structure predictions are available.
    3 View Details [315..596] PSI-BLAST 417.228787 beta-keto acyl carrier protein reductase
    4 View Details [597..699] MSA 1.026982 View MSA. No confident structure predictions are available.
    5 View Details [700..757] deduced N/A No confident structure predictions are available.
    6 View Details [758..900] MSA 11.039997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • CoA hydrolase activity
    		•  2.8126606339235 bayes_pls_golite062009
  • acyl-CoA thioesterase activity
    		•  2.60197973503923 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  1.58440062118102 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  1.14159464719086 bayes_pls_golite062009
  • catalytic activity
    		•  0.74605540351792 bayes_pls_golite062009
  • binding
    		•  0.713964827833761 bayes_pls_golite062009
  • hydrolase activity
    		•  0.679321026490004 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.616975153284172 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.65

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle