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View Structure Prediction Details

Protein: FOX2
Organism: Saccharomyces cerevisiae
Length: 900 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOX2.

Description E-value Query
Range
Subject
Range
FOX2 - Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA d...
FOX2_YEAST - Peroxisomal hydratase-dehydrogenase-epimerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...
0.0 [1..900] [1..900]
gi|9081979, gi|4... - gi|9081979|gb|AAF82684.1|AF198225_1 multifunctional beta-oxidation enzyme [Yarrowia lipolytica], gi|...
gi|49649849, gi|... - gi|50553140|ref|XP_503980.1| YALI0E15378p [Yarrowia lipolytica], gi|49649849|emb|CAG79573.1| unnamed...
0.0 [1..900] [1..901]
FOX2_CANTR - Peroxisomal hydratase-dehydrogenase-epimerase OS=Candida tropicalis PE=1 SV=2
0.0 [2..900] [1..906]
FOX2_NEUCR - Peroxisomal hydratase-dehydrogenase-epimerase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A /...
FOX2_NEUCR - Peroxisomal hydratase-dehydrogenase-epimerase OS=Neurospora crassa GN=fox-2 PE=1 SV=1
0.0 [1..893] [1..893]
gi|5869811 - gi|5869811|emb|CAB55552.1| Fox2 protein [Glomus mosseae]
0.0 [1..899] [1..874]
gi|123996759, gi... - gi|123996759|gb|ABM85981.1| hydroxysteroid (17-beta) dehydrogenase 4 [synthetic construct], gi|12398...
HSD17B4 - hydroxysteroid (17-beta) dehydrogenase 4
0.0 [314..897] [1..609]
gi|47523670, gi|... - gi|499340|emb|CAA55037.1| 17beta-estradiol dehydrogenase [Sus scrofa], gi|47523670|ref|NP_999471.1| ...
0.0 [314..900] [1..613]
DHB4_MOUSE - Peroxisomal multifunctional enzyme type 2 OS=Mus musculus GN=Hsd17b4 PE=1 SV=3
0.0 [314..897] [1..608]
gi|1881831 - gi|1881831|gb|AAB49519.1| 17 beta-hydroxysteroid dehydrogenase type IV; HSD IV [Rattus sp.]
DHB4_RAT - Peroxisomal multifunctional enzyme type 2 OS=Rattus norvegicus GN=Hsd17b4 PE=1 SV=3
0.0 [314..897] [1..608]

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Predicted Domain #1
Region A:
Residues: [1-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGNLSFKDR VVVITGAGGG LGKVYALAYA SRGAKVVVND LGGTLGGSGH NSKAADLVVD  60
   61 EIKKAGGIAV ANYDSVNENG EKIIETAIKE FGRVDVLINN AGILRDVSFA KMTEREFASV 120
  121 VDVHLTGGYK LSRAAWPYMR SQKFGRIINT ASPAGLFGNF GQANYSAAKM GLVGLAETLA 180
  181 KEGAKYNINV NSIAPLARSR MTENVLPPHI LKQLGPEKIV PLVLYLTHES TKVSNSIFEL 240
  241 AAGFFGQLRW ERSSGQIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.221849
Match: 1cwuA_
Description: Enoyl-ACP reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [259-314]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPDPKTYTPE AILNKWKEIT DYRDKPFNKT QHPYQLSDYN DLITKAKKLP PNEQGS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
CoA hydrolase activity 2.8126606339235 bayes_pls_golite062009
acyl-CoA thioesterase activity 2.60197973503923 bayes_pls_golite062009
thiolester hydrolase activity 1.58440062118102 bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity 1.14159464719086 bayes_pls_golite062009
catalytic activity 0.74605540351792 bayes_pls_golite062009
binding 0.713964827833761 bayes_pls_golite062009
hydrolase activity 0.679321026490004 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.616975153284172 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [315-596]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKIKSLCNKV VVVTGAGGGL GKSHAIWFAR YGAKVVVNDI KDPFSVVEEI NKLYGEGTAI  60
   61 PDSHDVVTEA PLIIQTAISK FQRVDILVNN AGILRDKSFL KMKDEEWFAV LKVHLFSTFS 120
  121 LSKAVWPIFT KQKSGFIINT TSTSGIYGNF GQANYAAAKA AILGFSKTIA LEGAKRGIIV 180
  181 NVIAPHAETA MTKTIFSEKE LSNHFDASQV SPLVVLLASE ELQKYSGRRV IGQLFEVGGG 240
  241 WCGQTRWQRS SGYVSIKETI EPEEIKENWN HITDFSRNTI NP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 417.228787
Match: 1edoA_
Description: beta-keto acyl carrier protein reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [597-699]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSTEESSMAT LQAVQKAHSS KELDDGLFKY TTKDCILYNL GLGCTSKELK YTYENDPDFQ  60
   61 VLPTFAVIPF MQATATLAMD NLVDNFNYAM LLHGEQYFKL CTP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [700-757]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TMPSNGTLKT LAKPLQVLDK NGKAALVVGG FETYDIKTKK LIAYNEGSFF IRGAHVPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [758-900]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKEVRDGKRA KFAVQNFEVP HGKVPDFEAE ISTNKDQAAL YRLSGDFNPL HIDPTLAKAV  60
   61 KFPTPILHGL CTLGISAKAL FEHYGPYEEL KVRFTNVVFP GDTLKVKAWK QGSVVVFQTI 120
  121 DTTRNVIVLD NAAVKLSQAK SKL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle