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Protein Overview: SIR2

Protein Complex Data

Mass Spectrometry Data

The following runs contain data for this protein:

  BAIT COMMENTS PUBLICATION
View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
View Run ASF1 3829 - low filter Green EM, et al (2005)
View Run RPA135 No Comments Schneider, DA, et al. (2006)
View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

  BAIT PREY HITS PUBLICATION
View Screen SPO21 SIR2 2 Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

  PROTEIN(S) PUBLICATION
View Data SIR2 Huh WK, et al. (2003)

Protein Structure Data


[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#   Region(s) Method Confidence Match Description
1 View Details [1..191] deduced N/A No confident structure predictions are available.
2 View Details [192..273]
[317..366]
[450..562]
PSI-BLAST 480.38764 Sirt2 histone deacetylase
3 View Details [274..316]
[367..449]
PSI-BLAST 480.38764 Sirt2 histone deacetylase

Functions predicted (by domain):

# Gene Ontology predictions
1 No functions predicted.
2 No functions predicted.
3
Term Confidence Notes
  • protein deacetylase activity
  • 11.8771442637949 bayes_pls_golite062009
  • histone deacetylase activity
  • 11.7308825525122 bayes_pls_golite062009
  • deacetylase activity
  • 10.8368006972109 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
  • 8.53375308475286 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
  • 8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
  • 8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
  • 7.45234027270448 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
  • 7.45234027270448 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
  • 7.0185004322765 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
  • 6.02509672218091 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
  • 5.11288441003953 bayes_pls_golite062009
  • tubulin deacetylase activity
  • 4.98963898611597 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
  • 4.84457718476539 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
  • 4.62921662347995 bayes_pls_golite062009
  • transcription regulator activity
  • 2.9155913558118 bayes_pls_golite062009
  • DNA binding
  • 2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
  • 2.41433477472968 bayes_pls_golite062009
  • transcription repressor activity
  • 2.24657784428979 bayes_pls_golite062009
  • binding
  • 2.06552694538163 bayes_pls_golite062009
  • NAD-independent histone deacetylase activity
  • 2.03444106183496 bayes_pls_golite062009
  • histone binding
  • 1.71445510915336 bayes_pls_golite062009
  • transcription corepressor activity
  • 1.64212790017753 bayes_pls_golite062009
  • protein binding
  • 1.52593340148652 bayes_pls_golite062009
  • nucleosome binding
  • 1.5125174755597 bayes_pls_golite062009
  • hydrolase activity
  • 1.43067365161346 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
  • 1.40719303660557 bayes_pls_golite062009
  • transcription factor activity
  • 1.30143289828088 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
  • 1.26370407179255 bayes_pls_golite062009
  • transcription factor binding
  • 1.14766678956419 bayes_pls_golite062009
  • NAD(P)+-protein-arginine ADP-ribosyltransferase activity
  • 0.963519974868694 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
  • 0.74741958699764 bayes_pls_golite062009
  • catalytic activity
  • 0.739210399081789 bayes_pls_golite062009
  • cation transmembrane transporter activity
  • 0.56434127203174 bayes_pls_golite062009
  • transcription cofactor activity
  • 0.54005617175343 bayes_pls_golite062009
  • transferase activity
  • 0.483523935618287 bayes_pls_golite062009




    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)


    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle