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The process, arising in dividing cells as they age, that alters cellular metabolism and thus causes a decline in cell function. Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Progression of the cell from its inception to the end of its lifespan. The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility. The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division. Process of enlargement and fragmentation of the nucleolus into multiple rounded structures that occurs in conjunction with increasing age in dividing cells. The process by which changes in chromatin structure contributing to replicative cell aging occurs.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: replicative cell aging
Acc: GO:0001302
Aspect: Biological Process
Desc: The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.
Synonyms:
  • replicative cell ageing
Proteins in PDR annotated with:
   This term: 61 [Search]
   Term or descendants: 76 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001302 - replicative cell aging (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle