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View Structure Prediction Details

Protein: HRR25
Organism: Saccharomyces cerevisiae
Length: 494 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HRR25.

Description E-value Query
Range		 Subject
Range
HRR25_YEAST - Casein kinase I homolog HRR25 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HRR25 PE=1...
HRR25 - Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, an...
 0.0 [1..494] [1..494]
KC1D_MOUSE - Casein kinase I isoform delta OS=Mus musculus GN=Csnk1d PE=1 SV=2
gi|117616262 - gi|117616262|gb|ABK42149.1| casein kinase I delta [synthetic construct]
KC1D_RAT - Casein kinase I isoform delta OS=Rattus norvegicus GN=Csnk1d PE=1 SV=2
 0.0 [1..437] [1..415]
gi|33303939 - gi|33303939|gb|AAQ02477.1| casein kinase 1, delta [synthetic construct]
 0.0 [1..437] [1..415]
CSNK1D - casein kinase 1, delta
gi|114671108 - gi|114671108|ref|XP_001167815.1| PREDICTED: casein kinase 1, delta isoform 3 [Pan troglodytes]
ENSCJAT00000035175 - null
KC1D_BOVIN - Casein kinase I isoform delta OS=Bos taurus GN=CSNK1D PE=2 SV=2
 0.0 [1..437] [1..415]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [1..437] [1..415]
gi|149055101, gi... - pir||A46002 casein kinase I (EC 2.7.1.-) delta, 49K isoform - rat, gi|294525|gb|AAA40934.1| casein ...
gi|74150005, gi|... - gi|74150005|dbj|BAE24329.1| unnamed protein product [Mus musculus], gi|148702869|gb|EDL34816.1| case...
 0.0 [1..451] [1..428]

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Predicted Domain #1
Region A:
Residues: [1-52] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLRVGRKFR IGRKIGSGSF GDIYHGTNLI SGEEVAIKLE SIRSRHPQLD YE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [68-84] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRWFGREGEY NAMVIDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1370.0
Match: 1ckiA_
Description: Casein kinase-1, CK1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
growth factor binding 0.86076618871384 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.835012681606991 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.835012681606991 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.832111648073981 bayes_pls_golite062009
nucleic acid binding 0.794058505655489 bayes_pls_golite062009
transcription regulator activity 0.775404673285876 bayes_pls_golite062009
DNA binding 0.714163549867672 bayes_pls_golite062009
ligase activity 0.665445021164512 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transcription factor activity 0.563262875317016 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
substrate-specific transporter activity 0.451090007290896 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
telethonin binding 0.366817170817532 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
kinase binding 0.26752427107238 bayes_pls_golite062009
MAP kinase activity 0.26024936404169 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.205652638854091 bayes_pls_golite062009
RNA binding 0.202560498527088 bayes_pls_golite062009
receptor binding 0.197402253061255 bayes_pls_golite062009
protein kinase C activity 0.0795689006739899 bayes_pls_golite062009
protein kinase binding 0.00674998152095019 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [53-67] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRVYRYLSGG VGIPF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [85-347] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGPSLEDLFN YCHRRFSFKT VIMLALQMFC RIQYIHGRSF IHRDIKPDNF LMGVGRRGST  60
   61 VHVIDFGLSK KYRDFNTHRH IPYRENKSLT GTARYASVNT HLGIEQSRRD DLESLGYVLI 120
  121 YFCKGSLPWQ GLKATTKKQK YDRIMEKKLN VSVETLCSGL PLEFQEYMAY CKNLKFDEKP 180
  181 DYLFLARLFK DLSIKLEYHN DHLFDWTMLR YTKAMVEKQR DLLIEKGDLN ANSNAASASN 240
  241 STDNKSETFN KIKLLAMKKF PTH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1370.0
Match: 1ckiA_
Description: Casein kinase-1, CK1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [348-494] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FHYYKNEDKH NPSPEEIKQQ TILNNNAASS LPEELLNALD KGMENLRQQQ PQQQVQSSQP  60
   61 QPQPQQLQQQ PNGQRPNYYP EPLLQQQQRD SQEQQQQVPM ATTRATQYPP QINSNNFNTN 120
  121 QASVPPQMRS NPQQPPQDKP AGQSIWL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle