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Protein Overview: VPS35

General Information:
Name(s) found: VPS35 / YJL154C [SGD]
Description(s) found:
Found 21 descriptions.
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  • Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 944 amino acids

    Gene Ontology:
    Cellular Component: retromer complex [IPILink to PubMed article]
    endosome [IPILink to PubMed article]
    Biological Process: protein retention in Golgi apparatus [IMPLink to PubMed article]
    retrograde transport, endosome to Golgi [IPILink to PubMed article]
    Molecular Function: protein binding [IGILink to PubMed article][IMPLink to PubMed article]
    protein transporter activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [NCBI BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYADSPENA IAVIKQRTAL MNRCLSQHKL MESLQHTSIM LTELRNPNLS PKKYYELYVI  60
   61 IFDSLTNLST YLIENHPQNH HLADLYELVQ YTGNVVPRLY LMITVGTSYL TFNEAPKKEI 120
  121 LKDMIEMCRG VQNPIRGLFL RYYLSQRTKE LLPEDDPSFN SQFIMNNFIE MNKLWVRLQH 180
  181 QGPLRERETR TRERKELQIL VGSQLVRLSQ IIDDNFQMYK QDILPTILEQ VIQCRDLVSQ 240
  241 EYLLDVICQV FADEFHLKTL DTLLQTTLHL NPDVSINKIV LTLVDRLNDY VTRQLEDDPN 300
  301 ATSTNAYLDM DVFGTFWDYL TVLNHERPDL SLQQFIPLVE SVIVLSLKWY PNNFDNLNKL 360
  361 FELVLQKTKD YGQKNISLES EHLFLVLLSF QNSKLQLTSS TTAPPNSPVT SKKHFIFQLI 420
  421 SQCQAYKNIL ALQSISLQKK VVNEIIDILM DREVEEMADN DSESKLHPPG HSAYLVIEDK 480
  481 LQVQRLLSIC EPLIISRSGP PANVASSDTN VDEVFFNRHD EEESWILDPI QEKLAHLIHW 540
  541 IMNTTSRKQT MKNKIQFSLE AQLEILLLIK SSFIKGGINV KYTFPAIITN FWKLMRKCRM 600
  601 IQEYLLKKRP DNKTLLSHYS NLLKQMFKFV SRCINDIFNS CNNSCTDLIL KLNLQCAILA 660
  661 DQLQLNEISY DFFSQAFTIF EESLSDSKTQ LQALIYIAQS LQKTRSLYKE AYYDSLIVRC 720
  721 TLHGSKLLKK QDQCRAVYLC SHLWWATEIS NIGEEEGITD NFYRDGKRVL ECLQRSLRVA 780
  781 DSIMDNEQSC ELMVEILNRC LYYFIHGDES ETHISIKYIN GLIELIKTNL KSLKLEDNSA 840
  841 SMITNSISDL HITGENNVKA SSNADDGSVI TDKESNVAIG SDGTYIQLNT LNGSSTLIRG 900
  901 VVATASGSKL LHQLKYIPIH HFRRTCEYIE SQREVDDRFK VIYV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) Manuscript in preparation. PEP8 VPS17 VPS29 VPS35 VPS5
    View Details (MIPS) Mewes HW, et al. (2004) PEP8 VPS29 VPS35
    View Details Krogan NJ, et al. (2006) MIA40 MUK1 PEP8 VPS17 VPS29 VPS35 VPS5
    View Details Gavin AC, et al. (2006) VPS29 VPS35 VPS5
    View Details Gavin AC, et al. (2002) VPS29 VPS35
    View Details Ho Y, et al. (2002) CIC1 ERB1 RPF1 SRP54 TMA108 VPS35 YBR242W YPD1 YTM1
    View Details Qiu et al. (2008) ATG20 DID4 PEP8 SNX41 VPS17 VPS29 VPS35 VPS5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VPS35 and SNF7 Huh WK, et al. (2003)
    View Data VPS35 Huh WK, et al. (2003)
    [View in YRC Public Image Repository] (2 experiment(s)and 6 images)

    Protein Structure Data


    [What does the above image mean?] [View Top Sequence Alignments]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..273] deduced N/A No confident structure predictions are available.
    2 View Details [274..892] MSA 2.014861 View MSA. No confident structure predictions are available.
    3 View Details [893..944] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.06764699542702 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.28572178684988 bayes_pls_golite062009
  • DNA binding
    		•  1.04384315974141 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.03072199805597 bayes_pls_golite062009
  • protein binding
    		•  0.504606394380961 bayes_pls_golite062009
  • transcription factor activity
    		•  0.482804592096741 bayes_pls_golite062009
  • transcription activator activity
    		•  0.163615553838647 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.119070203039683 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00383801605255352 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by:     Michael Riffle