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Protein Overview: TMA108

General Information:
Name(s) found: TMA108 / YIL137C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein that associates with ribosomes; putative metalloprotease [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 946 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    ribosome [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDNLLSLEN PVVPSHYELR LEIDPKQSSP NFKGSAIIHL KFNPNSTTLA SIEDSFTQFK  60
   61 LHSKDLIVLS AHATIGSTKF DLKISQDTGK HLSIFNSESP IQLSNDCPLI LSVQYVGKIR 120
  121 DIKTHHDKTF GIFKTNFMDR KTGTANNHVV ATHCQPFSAS NIFPCIDEPS NKSTFQLNIA 180
  181 TDAQYKAVSN TPVEMVEALD SSQKHLVKFA KTPLMTTSVF GFSIGDLEFL KTEIKLEGDR 240
  241 TIPVSIYAPW DIANAAFTLD TVQKYLPLLE SYFKCPYPLP KLDFVLLPYL SDMAMENFGM 300
  301 ITIQLNHLLI PPNALANETV REQAQQLIVH ELVHQWMGNY ISFDSWESLW FNESFATWLA 360
  361 CHILEQNGDL SHYWTSEPYL LQQVEPTMCR DAADVNGRSI FQIAQRNTGI DSQTSDIFDP 420
  421 EAYTKGIIML RSLQLATGES HLQKGLESVF EDTKTFHARS VKPMDIWNHI GKFLKSQNIT 480
  481 NFVSSWTRTP GLPVVKVEVE EKDGKTQTKL TQHRFINQLS TEEKDQLEDV PYQVPLFGVL 540
  541 PDGKMDTKNV LLTDRTLKFD YPILVINHLA QGYYRVSYES EECYALINDK ITEETLSEID 600
  601 LRKIFLDLSQ FIGDEGFQNS IHLHGLFKIL NHIASPSTKI ASKYWDPLSK GLEVLQTIDR 660
  661 ASLTSSKLQS FLKKKIVIPL FNKIDWPHGE FDKSTNPHEL KVMSQVLFLN KNSAKCAELC 720
  721 QIYFKHLLQG PRSSVPLELV NSILVVVSQH CANIKQWKKI FDLVKRSSCT GITNHVINMY 780
  781 DQNSSETAML IQNGAIESLG FCLDSDIVKK TLNFITSNIE SEGMELALFG FNYNFKKRLN 840
  841 KNEKPQDQVV RETIWEWYMG NFDQWARKAT RKGTTTGDHL HKALRSISLI IFQMFVADEP 900
  901 QKIEKFINLE KEKLGQSLLS LDDIWASVQQ DEESRKTIRR DLASLV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADE3 MIS1 RPP1B TMA108
    View Details Ho Y, et al. (2002) CIC1 ERB1 RPF1 SRP54 TMA108 VPS35 YBR242W YPD1 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TMA108 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..227] PSI-BLAST 169.9691 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    2 View Details [228..328] PSI-BLAST 169.9691 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    3 View Details [329..522] PSI-BLAST 169.9691 Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
    4 View Details [523..581] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [582..839] MSA 2.148961 View MSA. No confident structure predictions are available.
    6 View Details [840..946] deduced N/A Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle