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Protein Overview: ARO9

General Information:
Name(s) found: ARO9 / YHR137W [SGD]
Description(s) found:
Found 19 descriptions.
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  • Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 513 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: aromatic amino acid family metabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: aromatic-amino-acid:2-oxoglutarate aminotransferase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAGSAPPVD YTSLKKNFQP FLSRRVENRS LKSFWDASDI SDDVIELAGG MPNERFFPIE  60
   61 SMDLKISKVP FNDNPKWHNS FTTAHLDLGS PSELPIARSF QYAETKGLPP LLHFVKDFVS 120
  121 RINRPAFSDE TESNWDVILS GGSNDSMFKV FETICDESTT VMIEEFTFTP AMSNVEATGA 180
  181 KVIPIKMNLT FDRESQGIDV EYLTQLLDNW STGPYKDLNK PRVLYTIATG QNPTGMSVPQ 240
  241 WKREKIYQLA QRHDFLIVED DPYGYLYFPS YNPQEPLENP YHSSDLTTER YLNDFLMKSF 300
  301 LTLDTDARVI RLETFSKIFA PGLRLSFIVA NKFLLQKILD LADITTRAPS GTSQAIVYST 360
  361 IKAMAESNLS SSLSMKEAMF EGWIRWIMQI ASKYNHRKNL TLKALYETES YQAGQFTVME 420
  421 PSAGMFIIIK INWGNFDRPD DLPQQMDILD KFLLKNGVKV VLGYKMAVCP NYSKQNSDFL 480
  481 RLTIAYARDD DQLIEASKRI GSGIKEFFDN YKS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARO9 GND1 GND2
    View Details Ho Y, et al. (2002) ARO9 MMS2 RAD18 REX2 UBA1 UBC13

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ARO9 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..31]
    [51..395]    		 PSI-BLAST 152.9897 Aspartate aminotransferase, AAT
    2 View Details [32..50]
    [396..513]    		 PSI-BLAST 152.9897 Aspartate aminotransferase, AAT

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 4-aminobutyrate transaminase activity
    		•  2.50008459801306 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.08143587519879 bayes_pls_golite062009
  • DNA binding
    		•  1.80954597626789 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.80201988288625 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.63055151623667 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.63055151623667 bayes_pls_golite062009
  • transcription factor activity
    		•  1.4411091720163 bayes_pls_golite062009
  • transferase activity
    		•  1.44093490824786 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • kynureninase activity
    		•  1.27354164393136 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • binding
    		•  1.09053123792737 bayes_pls_golite062009
  • hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
    		•  0.942545094747784 bayes_pls_golite062009
  • hydrolase activity, acting on acid carbon-carbon bonds
    		•  0.845816961387768 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  0.619695949258279 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  0.54326874956263 bayes_pls_golite062009
  • structural molecule activity
    		•  0.347975812448725 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • aromatic-amino-acid:2-oxoglutarate aminotransferase activity
    		•  0.0916183433120769 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle