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Protein Overview: RKM1

General Information:
Name(s) found: RKM1 / YPL208W [SGD]
Description(s) found:
Found 23 descriptions.
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  • SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 583 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    Molecular Function: protein-lysine N-methyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDALKALL QWGASFGVIV PEELKFLYTD LKGIICVCEK DIDNPSIKIP PEIVISRNLP  60
   61 MKFFGLSEST KNINGWLKLF FAKIKFDRDN DTIVDNVRVN DKFKPYLDAL PSRLNSPLVW 120
  121 NPSELKRLSS TNIGNSIHEK FEGIFKEWFE LVSSSDMFDL ERVADDVQTF HNLDELTYEA 180
  181 LYEKILKITE LQRPTIWYSF PAFLWSHLIF ISRAFPEYVL NRNCPDNSIV LLPIVDLLNH 240
  241 DYRSKVKWYP ENGWFCYEKI GTASQSRELS NNYGGKGNEE LLSGYGFVLE DNIFDSVALK 300
  301 VKLPLDVVST ILETEPSLKL PLLSDYTTYA FENKDCVQQE KKATRSATDY INGVTYFINI 360
  361 QNEQCLEPLL DLFTYLSKAE EEDLHDLRAR LQGIQMLRNA LQSKLNSITG PPATDDSYAI 420
  421 DPYRVYCADV YTKGQKQILK EALTRLKKLE KTMLSENKHQ LLTMSKILKN DPAFAETELP 480
  481 SLFSNEDGEE VIFESTYDLL ILWILLKTKK NSYPTKYEWV GQQYTNFKQT AYISDDAKAF 540
  541 HTAYFEKQDD VDLAEVDHAI QFVVDNSFTR TSSTTEETIL VRK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BCP1 RKM1
    View Details Krogan NJ, et al. (2006) RKM1 YMR1
    View Details Gavin AC, et al. (2006) BCP1 RKM1
    View Details Gavin AC, et al. (2002) BCP1 GFA1 GLT1 KAP123 NOC2 RKM1 SSA4 YOL098C
    View Details Ho Y, et al. (2002) BCP1 FET4 IMD4 RKM1 RPL23B, RPL23A

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RKM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113]
    [142..274]    		 PSI-BLAST 72.0 RuBisCo LSMT C-terminal, substrate-binding domain; RuBisCo LSMT catalytic domain
    2 View Details [114..141]
    [275..299]
    [401..442]    		 PSI-BLAST 72.0 RuBisCo LSMT C-terminal, substrate-binding domain; RuBisCo LSMT catalytic domain
    3 View Details [300..400]
    [443..512]    		 PSI-BLAST 72.0 RuBisCo LSMT C-terminal, substrate-binding domain; RuBisCo LSMT catalytic domain
    4 View Details [513..583] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • histone methyltransferase activity
    		•  6.20878333364554 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  6.08778683840554 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  5.45106430536252 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  5.45106430536252 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  5.45106430536252 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.98411678860954 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K9 specific)
    		•  3.54138873512018 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.69428385009711 bayes_pls_golite062009
  • methyltransferase activity
    		•  2.33114816345072 bayes_pls_golite062009
  • binding
    		•  2.2675356705139 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  2.25175257044903 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.79964884912488 bayes_pls_golite062009
  • chromatin binding
    		•  1.00298380074254 bayes_pls_golite062009
  • protein binding
    		•  0.938282161933492 bayes_pls_golite062009
  • transferase activity
    		•  0.653108419761009 bayes_pls_golite062009
  • catalytic activity
    		•  0.414641636618101 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle