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View Structure Prediction Details

Protein: RKM1
Organism: Saccharomyces cerevisiae
Length: 583 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RKM1.

Description E-value Query
Range
Subject
Range
RKM1_YEAST - Ribosomal lysine N-methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=R...
RKM1 - SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the lar...
0.0 [1..583] [1..583]
SETD3_MOUSE - Histone-lysine N-methyltransferase setd3 OS=Mus musculus GN=Setd3 PE=1 SV=1
8.0E-90 [4..464] [77..509]
SETD3 - SET domain containing 3
5.0E-89 [4..464] [77..509]
SET10_SCHPO - Ribosomal lysine N-methyltransferase set10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...
SPBC1709.13c - lysine methyltransferase
4.0E-78 [6..504] [1..463]
SETD3_DANRE - Histone-lysine N-methyltransferase setd3 OS=Danio rerio GN=setd3 PE=1 SV=1
1.0E-77 [4..443] [77..479]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-76 [6..464] [56..477]
RBCMT_ARATH - [Fructose-bisphosphate aldolase]-lysine N-methyltransferase, chloroplastic OS=Arabidopsis thaliana G...
4.0E-74 [2..464] [45..469]

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Predicted Domain #1
Region A:
Residues: [1-113]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDALKALL QWGASFGVIV PEELKFLYTD LKGIICVCEK DIDNPSIKIP PEIVISRNLP  60
   61 MKFFGLSEST KNINGWLKLF FAKIKFDRDN DTIVDNVRVN DKFKPYLDAL PSR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [142-274]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGIFKEWFEL VSSSDMFDLE RVADDVQTFH NLDELTYEAL YEKILKITEL QRPTIWYSFP  60
   61 AFLWSHLIFI SRAFPEYVLN RNCPDNSIVL LPIVDLLNHD YRSKVKWYPE NGWFCYEKIG 120
  121 TASQSRELSN NYG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.0
Match: 1mlvA_
Description: RuBisCo LSMT C-terminal, substrate-binding domain; RuBisCo LSMT catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
histone methyltransferase activity 6.20878333364554 bayes_pls_golite062009
protein methyltransferase activity 6.08778683840554 bayes_pls_golite062009
lysine N-methyltransferase activity 5.45106430536252 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 5.45106430536252 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 5.45106430536252 bayes_pls_golite062009
N-methyltransferase activity 3.98411678860954 bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific) 3.54138873512018 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 2.69428385009711 bayes_pls_golite062009
methyltransferase activity 2.33114816345072 bayes_pls_golite062009
binding 2.2675356705139 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 2.25175257044903 bayes_pls_golite062009
nucleic acid binding 1.79964884912488 bayes_pls_golite062009
chromatin binding 1.00298380074254 bayes_pls_golite062009
protein binding 0.938282161933492 bayes_pls_golite062009
transferase activity 0.653108419761009 bayes_pls_golite062009
catalytic activity 0.414641636618101 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [114-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNSPLVWNPS ELKRLSSTNI GNSIHEKF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [275-299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKGNEELLSG YGFVLEDNIF DSVAL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [401-442]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQSKLNSITG PPATDDSYAI DPYRVYCADV YTKGQKQILK EA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.0
Match: 1mlvA_
Description: RuBisCo LSMT C-terminal, substrate-binding domain; RuBisCo LSMT catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [300-400]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVKLPLDVVS TILETEPSLK LPLLSDYTTY AFENKDCVQQ EKKATRSATD YINGVTYFIN  60
   61 IQNEQCLEPL LDLFTYLSKA EEEDLHDLRA RLQGIQMLRN A

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [443-512]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTRLKKLEKT MLSENKHQLL TMSKILKNDP AFAETELPSL FSNEDGEEVI FESTYDLLIL  60
   61 WILLKTKKNS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.0
Match: 1mlvA_
Description: RuBisCo LSMT C-terminal, substrate-binding domain; RuBisCo LSMT catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [513-583]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPTKYEWVGQ QYTNFKQTAY ISDDAKAFHT AYFEKQDDVD LAEVDHAIQF VVDNSFTRTS  60
   61 STTEETILVR K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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