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Catalysis of the addition of a methyl group onto lysine at position 20 of the histone H4 protein. Catalysis of the addition of a methyl group onto lysine at position 79 of the histone H3 protein. Catalysis of the addition of a methyl group onto lysine at position 9 of the histone H3 protein. Catalysis of the addition of a methyl group onto lysine at position 36 of the histone H3 protein. Catalysis of the transfer of a methyl group (CH3-) to a protein. Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. Catalysis of the addition of a methyl group onto lysine at position 4 of the histone H3 protein. Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. Catalysis of the addition of a methyl group onto lysine at position 27 of the histone H3 protein. Catalysis of the transfer of a methyl group (CH3-) to a histone. Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: histone-lysine N-methyltransferase activity
Acc: GO:0018024
Aspect: Molecular Function
Desc: Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
Synonyms:
  • histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity
  • protein methyltransferase II activity
  • S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity
  • protein methylase III activity
  • protein (lysine) methyltransferase activity
  • S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity
  • protein methylase 3 activity
  • histone-lysine N-methylase activity
Proteins in PDR annotated with:
   This term: 91 [Search]
   Term or descendants: 140 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0018024 - histone-lysine N-methyltransferase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle