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Protein Overview: CUS1

General Information:
Name(s) found: CUS1 / YMR240C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 436 amino acids

    Gene Ontology:
    Cellular Component: U2 snRNP [IDALink to PubMed articleLink to PubMed article]
    Biological Process: spliceosome assembly [IDALink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]
    protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARTKSRKRS GNNQNKNASV VNNKAEIAAM IDARRLEQKK KGGVTNSKGK TNKVVDAKLE  60
   61 KEFKDVLQRF QVQENDTPKE ITKDEKNNHV VIVEKNPVMN RKHTAEDELE DTPSDGIEEH 120
  121 LSARKRRKTE KPSLSQLKSQ VPYPQIIEWY DCDARYPGLL ASIKCTKNVI PVPSHWQSKK 180
  181 EYLSGRSLLG KRPFELPDII KKTNIEQMRS TLPQSGLDGQ DEKSLKEASR ARVQPKMGAL 240
  241 DLDYKKLHDV FFKIGANWKP DHLLCFGDVY YENRNLFEET NWKRMVDHKR PGRISQELRA 300
  301 IMNLPEGQLP PWCMKMKDIG LPTGYPDLKI AGLNWDITNL KGDVYGKIIP NHHSRSKKQG 360
  361 RNYFGALISF ETPEFENSKE DTQANAENGR QDDKIDDEVE HKLDHFQEDI SEVTSAEEKL 420
  421 ERNEEESEKQ LYTVLK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR2 CLF1 CSN12 CUS1 DIB1 HSH155 HSH49 LEA1 MSL1 PRP11 PRP19 PRP21 PRP3 PRP31 PRP4 PRP40 PRP46 PRP6 PRP8 PRP9 RSE1 SMB1 SMD1 SMD2 SMD3 SME1 SNU114 SNU23 SNU66 SNU71 SPP382 STO1
    View Details Krogan NJ, et al. (2006) BUD13 BUD31 CUS1 CWC21 HSH155 HSH49 LEA1 LOT6 PRP11 PRP21 PRP45 PRP9 RSE1
    View Details Gavin AC, et al. (2006) BRR2 CUS1 HSH155 HSH49 LEA1 MSL1 PRP11 PRP21 PRP3 PRP31 PRP4 PRP6 PRP8 PRP9 RSE1 SMB1 SNU114 SNU23 SNU66 SPP381
    View Details Gavin AC, et al. (2002) AAR2 BRR1 BUD31 CBC2 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM8 NPL3 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SYF1 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC22 CWC23 DHR2 DIB1 ECM2 HSH155 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP5 PRP6 PRP8 PRP9 RDS3 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CUS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..279] deduced N/A No confident structure predictions are available.
    2 View Details [280..436] MSA 3.014996 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle