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Protein Overview: PRP45

General Information:
Name(s) found: PRP45 / YAL032C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 379 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    spliceosomal complex [IPILink to PubMed article]
    Biological Process: positive regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    nuclear mRNA splicing, via spliceosome [IMPLink to PubMed article]
    Molecular Function: transcription activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSNRLPPPK HSQGRVSTAL SSDRVEPAIL TDQIAKNVKL DDFIPKRQSN FELSVPLPTK  60
   61 AEIQECTART KSYIQRLVNA KLANSNNRAS SRYVTETHQA PANLLLNNSH HIEVVSKQMD 120
  121 PLLPRFVGKK ARKVVAPTEN DEVVPVLHMD GSNDRGEADP NEWKIPAAVS NWKNPNGYTV 180
  181 ALERRVGKAL DNENNTINDG FMKLSEALEN ADKKARQEIR SKMELKRLAM EQEMLAKESK 240
  241 LKELSQRARY HNGTPQTGAI VKPKKQTSTV ARLKELAYSQ GRDVSEKIIL GAAKRSEQPD 300
  301 LQYDSRFFTR GANASAKRHE DQVYDNPLFV QQDIESIYKT NYEKLDEAVN VKSEGASGSH 360
  361 GPIQFTKAES DDKSDNYGA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BUD31 CDC40 CEF1 CLF1 CWC2 CWC22 HSH155 ISY1 PRP19 PRP2 PRP45 PRP46 PRP8 RSE1 SNT309 SNU114 SYF1
    View Details Hazbun TR, et al. (2003) BRR2 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 ECM2 ISY1 LEA1 NTR2 PRP19 PRP43 PRP45 PRP46 PRP8 SMB1 SMD1 SMD3 SMX3 SNT309 SNU114 SPP382 SYF1 SYF2 YJU2
    View Details Krogan NJ, et al. (2006) BUD13 BUD31 CUS1 CWC21 HSH155 HSH49 LEA1 LOT6 PRP11 PRP21 PRP45 PRP9 RSE1
    View Details Gavin AC, et al. (2006) CDC40 CEF1 CLF1 CWC2 CWC22 ECM2 PRP19 PRP45 PRP46 SYF1
    View Details Gavin AC, et al. (2002) BUD31 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 ECM2 HSH155 ISY1 LEA1 PRP19 PRP2 PRP21 PRP22 PRP43 PRP45 PRP46 RSE1 SMD2 SNT309 SNU114 SPP382 STO1 SYF1
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CDC40 CLF1 CWC15 CWC2 CWC22 CWC23 DHR2 ECM2 ISY1 LSM4 MAK5 MUD1 MUD2 PRP19 PRP2 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP45 PRP5 PRP6 PRP8 PRP9 SLU7 SMD1 SMD3 SME1 SNU114 SPP2 SPP381 STO1 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run SPP382 No Comments Hazbun TR, et al. (2003)
    View Run SPP382 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen KAP104 PRP45 2 Unpublished Fields Lab Data
    View Screen MDM30 PRP45 2 Unpublished Fields Lab Data
    View Screen SPP382 PRP45 2 Hazbun TR, et al. (2003)
    View Screen SOG2 PRP45 2 Unpublished Fields Lab Data
    View Screen ILM1 PRP45 2 Lockshon D, et al. (2006)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRP45 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..57] MSA 1.013991 View MSA. No confident structure predictions are available.
    2 View Details [58..312] Pfam 109.853872 SKIP/SNW domain No confident structure predictions are available.
    3 View Details [313..379] deduced N/A No confident structure predictions are available.
    4 View Details [298..379] MSA 4.029995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.59005615358803 bayes_pls_golite062009
  • protein binding
    		•  2.41769888237582 bayes_pls_golite062009
  • tubulin binding
    		•  0.684160753873506 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.538779930266561 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle