YRC Public Data Repository - Protein Structure Prediction

Protein:	TIF4631
Organism:	Saccharomyces cerevisiae
Length:	952 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIF4631.

Description	E-value	Query Range	Subject Range
TIF4631 - Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that al... gi\|190406822 - gi\|190406822\|gb\|EDV10089.1\| eukaryotic initiation factor 4F subunit p150 [Saccharomyces cerevisiae R... IF4F1_YEAST - Eukaryotic initiation factor 4F subunit p150 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...	0.0	[1..952]	[1..952]
gi\|3941724 - gi\|3941724\|gb\|AAC82471.1\| eukaryotic protein synthesis initiation factor [Homo sapiens]	0.0	[9..911]	[119..1015]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	4.0E-95	[451..939]	[64..544]
IF4G1_WHEAT - Eukaryotic translation initiation factor isoform 4G-1 OS=Triticum aestivum PE=1 SV=2	2.0E-93	[451..939]	[65..545]
IF4G2_ARATH - Eukaryotic translation initiation factor isoform 4G-2 OS=Arabidopsis thaliana GN=EIF(ISO)4G2 PE=1 SV...	3.0E-92	[430..939]	[37..516]
IF4G1_RABIT - Eukaryotic translation initiation factor 4 gamma 1 OS=Oryctolagus cuniculus GN=EIF4G1 PE=1 SV=1	2.0E-91	[52..911]	[6..858]

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Predicted Domain #1

Region A:
Residues: [1-82]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDETAHPTQ SASKQESAAL KQTGDDQQES QQQRGYTNYN NGSNYTQKKP YNSNRPHQQR  60
   61 GGKFGPNRYN NRGNYNGGGS FR

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	12.14
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted Domain #2

Region A:
Residues: [83-402]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGHMGANSSN VPWTGYYNNY PVYYQPQQMA AAGSAPANPI PVEEKSPVPT KIEITTKSGE  60
   61 HLDLKEQHKA KLQSQERSTV SPQPESKLKE TSDSTSTSTP TPTPSTNDSK ASSEENISEA 120
  121 EKTRRNFIEQ VKLRKAALEK KRKEQLEGSS GNNNIPMKTT PENVEEKGSD KPEVTEKTKP 180
  181 AEEKSAEPEV KQETPAEEGE QGEKGQIKEE STPKVLTFAE RLKLKKQQKE REEKTEGKEN 240
  241 KEVPVQEETK SAIESAPVPP SEQVKEETEV AETEQSNIDE SATTPAIPTK SDEAEAEVEA 300
  301 EAGDAGTKIG LEAEIETTTD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.91
Match:	1jv2B
Description:	Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [403-505]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETDDGTNTVS HILNVLKDAT PIEDVFSFNY PEGIEGPDIK YKKEHVKYTY GPTFLLQFKD  60
   61 KLNVKADAEW VQSTASKIVI PPGMGRGNRS RDSGRFGNNS SRG

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	10.91
Match:	1jv2B
Description:	Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	10.603094323259	bayes_pls_golite062009
translation factor activity, nucleic acid binding	6.05435928492991	bayes_pls_golite062009
translation regulator activity	6.02151774494908	bayes_pls_golite062009
binding	1.66056773797288	bayes_pls_golite062009
nucleic acid binding	1.33292024661028	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [506-591]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDFRNTSVRN MDDRANSRTS SKRRSKRMND DRRSNRSYTS RRDRERGSYR NEEKREDDKP  60
   61 KEEVAPLVPS ANRWVPKFKS KKTEKK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [592-731]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAPDGKTELL DKDEVERKMK SLLNKLTLEM FDAISSEILA IANISVWETN GETLKAVIEQ  60
   61 IFLKACDEPH WSSMYAQLCG KVVKELNPDI TDETNEGKTG PKLVLHYLVA RCHAEFDKGW 120
  121 TDKLPTNEDG TPLEPEMMSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	310.165202
Match:	1hu3A_
Description:	Eukaryotic initiation factor eIF4G
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	9.72578576774139	bayes_pls_golite062009
RNA cap binding	6.12623630895688	bayes_pls_golite062009
translation factor activity, nucleic acid binding	5.51508149717622	bayes_pls_golite062009
translation regulator activity	5.47755138510933	bayes_pls_golite062009
structural molecule activity	4.37969512292045	bayes_pls_golite062009
binding	2.48958374349477	bayes_pls_golite062009
RNA binding	1.98024495780436	bayes_pls_golite062009
protein binding	1.94427330399472	bayes_pls_golite062009
nucleic acid binding	1.14394632253646	bayes_pls_golite062009
signal sequence binding	0.289133192719901	bayes_pls_golite062009
cytoskeletal protein binding	0.232758919136574	bayes_pls_golite062009
transcription regulator activity	0.223441052840823	bayes_pls_golite062009
DNA binding	0.206335065849379	bayes_pls_golite062009
mRNA binding	0.12130984199507	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [732-890]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYYAAASAKR RGLGLVRFIG FLYRLNLLTG KMMFECFRRL MKDLTDSPSE ETLESVVELL  60
   61 NTVGEQFETD SFRTGQATLE GSQLLDSLFG ILDNIIQTAK ISSRIKFKLI DIKELRHDKN 120
  121 WNSDKKDNGP KTIQQIHEEE ERQRQLKNNS RSNSRRTNN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	310.165202
Match:	1hu3A_
Description:	Eukaryotic initiation factor eIF4G
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [891-952]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSNRHSFRRD APPASKDSFI TTRTYSQRNS QRAPPPKEEP AAPTSTATNM FSALMGESDD  60
   61 EE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: