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Protein Overview: RPN10

General Information:
Name(s) found: RPN10 / YHR200W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 268 amino acids

    Gene Ontology:
    Cellular Component: proteasome regulatory particle, base subcomplex [IPILink to PubMed articleLink to PubMed article]
    proteasome complex [IMPLink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: endopeptidase activity [TASLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLEATVLVI DNSEYSRNGD FPRTRFEAQI DSVEFIFQAK RNSNPENTVG LISGAGANPR  60
   61 VLSTFTAEFG KILAGLHDTQ IEGKLHMATA LQIAQLTLKH RQNKVQHQRI VAFVCSPISD 120
  121 SRDELIRLAK TLKKNNVAVD IINFGEIEQN TELLDEFIAA VNNPQEETSH LLTVTPGPRL 180
  181 LYENIASSPI ILEEGSSGMG AFGGSGGDSD ANGTFMDFGV DPSMDPELAM ALRLSMEEEQ 240
  241 QRQERLRQQQ QQQDQPEQSE QPEQHQDK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ECM29 GSG1 NAS6 OSH7 POL4 PRE5 RPN1 RPN10 RPN11 RPN12 RPN13 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SEC18 SEM1 SLX5 SPG5 SWA2 UBP6
    View Details (MIPS) Mewes HW, et al. (2004) NAS6 RPN1 RPN10 RPN11 RPN12 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Gavin AC, et al. (2006) ECM29 RPN1 RPN10 RPN11 RPN12 RPN13 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1
    View Details Gavin AC, et al. (2002) ACC1 ASC1 BLM10 CCT8 CDC6 CLU1 CPA2 DNA2 ECM29 FDH1 FKS1 GCN1 GCN20 GFA1 GUS1 ILV1 KAP123 KAP95 LYS12 MEC1 MET18 MLH2 MPH1 MRPL3 MRPS28 MSH2 MSH6 NAS6 NUM1 OPI1 OSH2 PGK1 PIL1 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PSA1 PUP3 RAD23 RAD3 RAD34 RAD4 RAD52 RFA1 RFA2 RGR1 RPA135 RPB2 RPN10 RPN11 RPN12 RPN13 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SAM1 SCL1 SCS2 SEC27 SMC3 SRO7 SSL1 STT4 SWH1 TCB1 TFA1 TFB1 TFB4 TFP1 TIF1, TIF2 TSA1 TUB3 UBP6 URA7 VAS1 YAR044W YDJ1 YFL006W YOL098C
    View Details Ho Y, et al. (2002) AAC1 AAC3 ADE5,7 AHA1 ARC1 ARO1 ARP2 ARP7 ATG11 ATG12 ATG17 CAR2 CPA2 CPR6 DIG1 DIG2 FET4 GCD11 GFA1 GUS1 HAS1 HXT6 HYP2 IPP1 KSS1 MKT1 MSE1 NAP1 PHO84 PIM1 PMA1 POR1 PPX1 PRB1 PTC7 PYC1 REP1 REX2 RGC1 RPA135 RPN1 RPN10 RPN11 RPN13 RPN14 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 SEC18 SEN1 STE12 STE7 TCB1 TEC1 TIF1, TIF2 TYR1 UBI4 YDR239C YHR020W YHR033W YNL208W
    View Details Qiu et al. (2008) NAS6 PRE10 PRE2 PRE3 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 RPN1 RPN10 RPN11 RPN12 RPN13 RPN2 RPN3 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SCL1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen KAP104 RPN10 1 Unpublished Fields Lab Data
    View Screen SWI5 RPN10 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RPN10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..197] ORFEUS 15.0 Integrin CD11a/CD18 (Leukocyte function associated antigen-1, LFA-1)
    2 View Details [198..268] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  4.02098822555334 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.82496592594463 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.72596563304893 bayes_pls_golite062009
  • binding
    		•  3.32950434867692 bayes_pls_golite062009
  • hydrolase activity
    		•  2.72944528058473 bayes_pls_golite062009
  • protein binding
    		•  1.4332924081006 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.41389987484225 bayes_pls_golite062009
  • DNA binding
    		•  1.27751137443334 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.45109468643752 bayes_pls_golite062009
  • protein complex binding
    		•  0.0341925447010603 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.0195372592716698 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle