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Protein Overview: OSH2

General Information:
Name(s) found: OSH2 / YDL019C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1283 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: sterol transport [IGILink to PubMed article]
    endocytosis [IGILink to PubMed article]
    exocytosis [IGILink to PubMed article]
    Molecular Function: oxysterol binding [ISSLink to PubMed article]
    phosphatidylinositol binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSREDLSIAE DLNQVSKPLL KVKLLEVLGQ GDFKHLKALV DNEFQPKDDP SVQQVLNLIL  60
   61 HYAVQVAPIL LIKEIVAHWV DQVGDEKSSS KSDDGIHLDL NYQDENGNTP LHLAAAQSRS 120
  121 DVISFLLSQK SINDCVKNKA HQQPLDMCKD LNVAQMIQLK RDDYFLETVH SLRAAMNKRD 180
  181 FSKLDSIWKN PRNLNLLDIN GIDPETGTTL LYEYSQKKDI EMCQWLLKHG AEATVKDGKG 240
  241 RSPLDLVKNI KLPAKPSNNV TPEIKLKNLL EKNLREQAIV HEDVASSKPP TYKGFLKKWT 300
  301 NFAHGYKLRW FILSGDGNLS YYKDQSHVDR PRGTLKVSTC RLHIDSSEKL NFELLGGITG 360
  361 TTRWRLKGNH PIETTRWVNA IQSAIRFAKD KEILNKKKAV PPSLALKNKS PALISHSKTQ 420
  421 GSLPEASQYY QHTLHKEVIQ PSSVSLYRRP SNNLSVVSSE IQLNDNLTES GKRFVSKMIE 480
  481 NRLDGSKTPV GVHTGSALQR VRSSNTLKSN RSMQSGSGVA SPIDKVPNGA NLSQSNTTTG 540
  541 STASLSDNNY IDNFEGDEAN SDDEEEDLGI NFDRDEEYIK AQYGPYKEKL DMYEQAISIE 600
  601 LSSLIELIEQ EEPSPEVWLT IKKSLINTST IFGKLKDLTY KRDKRLVDMV SKQGDVNNVW 660
  661 VQSVKELEME LSNKTERLAS IDKERRGLKK ILHKKLLESH ATAGNKESLE NDKEQESDTT 720
  721 ASTLGQIAKF ISATKEEDEA SDADEFYDAA ELVDEVTELT EAHPEISTAA APKHAPPPVP 780
  781 NETDNDSQYV QDEKSKIESN VEKTSQKFEK QNNLVTEDEP KTDQSLKNFK AEDKESQVKE 840
  841 KTKEIASSVI GEKTIVAVTT VQKRKEEYLL KEGSYLGYED GIRKRLSMDK DDRPKISLWA 900
  901 VLKSMVGKDM TRMTLPVTFN EPTSLLQRVA EDLEYSELLD QAATFEDSTL RTLYVAAFTA 960
  961 SSYASTTKRV AKPFNPLLGE TFEYSRPDKQ YRFFTEQVSH HPPISATWTE SPRWDFWGES1020
 1021 FVDTKFNGRS FNVKHLGLWH IKLRPNDNEK EELYTWKKPN NTVIGILIGN PQVDNHGEVN1080
 1081 VVNHTTGDHC KLYFKARGWR SSGAYEITGE VYNKKKQKVW ILGGHWNEAI FAKKVVKDGD1140
 1141 LSLEKTRTAA SAGNGPTDDG TKFLIWKAND RPEEPFNLTP FAITLNAPQP HLLPWLPPTD1200
 1201 TRLRPDQRAM EDGRYDEAGD EKFRVEEKQR AARRKREENN LEYHPQWFVR DTHPITKAKY1260
 1261 WRYTGKYWVK RRDHDLKDCG DIF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) OSH2 SWH1
    View Details Krogan NJ, et al. (2006) OSH2 SWH1
    View Details Gavin AC, et al. (2002) FKS1 NUM1 OPI1 OSH2 PIL1 RPN10 SCS2 STT4 SWH1 YAR044W
    View Details Qiu et al. (2008) BEM1 BOI1 BOI2 GYL1 KES1 OSH2 SWH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OSH2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] PSI-BLAST 43.154902 bcl-3
    2 View Details [136..273] PSI-BLAST 43.154902 bcl-3
    3 View Details [274..401] ORFEUS 14.78 Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH
    4 View Details [402..542] deduced N/A No confident structure predictions are available.
    5 View Details [543..888] PSI-BLAST 3.69897 Heavy meromyosin subfragment
    6 View Details [889..1283] MSA 7.077932 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.03195138036959 bayes_pls_golite062009
  • protein binding
    		•  1.6716587413544 bayes_pls_golite062009
  • transporter activity
    		•  1.19000052859754 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.02570255606772 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.581121752453591 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.428839878681413 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.240863793118641 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.16792752511707 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • sterol binding
    		•  4.18891468109664 bayes_pls_golite062009
  • oxysterol binding
    		•  3.82897024895265 bayes_pls_golite062009
    		• 3.02967613614595 bayes_pls_golite062009
  • steroid binding
    		•  2.54679035876403 bayes_pls_golite062009
  • phosphoinositide binding
    		•  2.2725849852584 bayes_pls_golite062009
  • phospholipid binding
    		•  2.08170907241909 bayes_pls_golite062009
  • binding
    		•  1.96043183869108 bayes_pls_golite062009
  • lipid binding
    		•  1.8520231230392 bayes_pls_golite062009
  • cholesterol binding
    		•  0.644339278395346 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle