YRC Public Data Repository - Protein Structure Prediction

Protein:	OSH2
Organism:	Saccharomyces cerevisiae
Length:	1283 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OSH2.

Description	E-value	Query Range	Subject Range
OSH2 - Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members ha... OSH2_YEAST - Oxysterol-binding protein homolog 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OSH2...	0.0	[1..1283]	[1..1283]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..1283]	[1..1190]
YB35_SCHPO - Oxysterol-binding protein homolog C2F12.05c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G... SPBC2F12.05c - sterol binding ankyrin repeat protein	0.0	[8..1283]	[15..1310]
gi\|16117300 - gi\|16117300\|dbj\|BAB03559.2\| hypothetical protein [Macaca fascicularis]	0.0	[529..1278]	[108..824]
gi\|14042387 - gi\|14042387\|dbj\|BAB55223.1\| unnamed protein product [Homo sapiens]	0.0	[639..1283]	[89..719]
ORP1A_ARATH - Oxysterol-binding protein-related protein 1A OS=Arabidopsis thaliana GN=ORP1A PE=2 SV=1	0.0	[628..1283]	[112..752]

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Predicted Domain #1

Region A:
Residues: [1-135]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSREDLSIAE DLNQVSKPLL KVKLLEVLGQ GDFKHLKALV DNEFQPKDDP SVQQVLNLIL  60
   61 HYAVQVAPIL LIKEIVAHWV DQVGDEKSSS KSDDGIHLDL NYQDENGNTP LHLAAAQSRS 120
  121 DVISFLLSQK SINDC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.154902
Match:	1k1aA_
Description:	bcl-3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.03195138036959	bayes_pls_golite062009
protein binding	1.6716587413544	bayes_pls_golite062009
transporter activity	1.19000052859754	bayes_pls_golite062009
transmembrane transporter activity	1.02570255606772	bayes_pls_golite062009
substrate-specific transporter activity	0.581121752453591	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.428839878681413	bayes_pls_golite062009
ion transmembrane transporter activity	0.240863793118641	bayes_pls_golite062009
substrate-specific channel activity	0.16792752511707	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [136-273]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKNKAHQQPL DMCKDLNVAQ MIQLKRDDYF LETVHSLRAA MNKRDFSKLD SIWKNPRNLN  60
   61 LLDINGIDPE TGTTLLYEYS QKKDIEMCQW LLKHGAEATV KDGKGRSPLD LVKNIKLPAK 120
  121 PSNNVTPEIK LKNLLEKN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.154902
Match:	1k1aA_
Description:	bcl-3
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [274-401]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LREQAIVHED VASSKPPTYK GFLKKWTNFA HGYKLRWFIL SGDGNLSYYK DQSHVDRPRG  60
   61 TLKVSTCRLH IDSSEKLNFE LLGGITGTTR WRLKGNHPIE TTRWVNAIQS AIRFAKDKEI 120
  121 LNKKKAVP

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.78
Match:	1faoA
Description:	Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [402-542]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSLALKNKSP ALISHSKTQG SLPEASQYYQ HTLHKEVIQP SSVSLYRRPS NNLSVVSSEI  60
   61 QLNDNLTESG KRFVSKMIEN RLDGSKTPVG VHTGSALQRV RSSNTLKSNR SMQSGSGVAS 120
  121 PIDKVPNGAN LSQSNTTTGS T

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [543-888]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASLSDNNYID NFEGDEANSD DEEEDLGINF DRDEEYIKAQ YGPYKEKLDM YEQAISIELS  60
   61 SLIELIEQEE PSPEVWLTIK KSLINTSTIF GKLKDLTYKR DKRLVDMVSK QGDVNNVWVQ 120
  121 SVKELEMELS NKTERLASID KERRGLKKIL HKKLLESHAT AGNKESLEND KEQESDTTAS 180
  181 TLGQIAKFIS ATKEEDEASD ADEFYDAAEL VDEVTELTEA HPEISTAAAP KHAPPPVPNE 240
  241 TDNDSQYVQD EKSKIESNVE KTSQKFEKQN NLVTEDEPKT DQSLKNFKAE DKESQVKEKT 300
  301 KEIASSVIGE KTIVAVTTVQ KRKEEYLLKE GSYLGYEDGI RKRLSM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.69897
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
sterol binding	4.18891468109664	bayes_pls_golite062009
oxysterol binding	3.82897024895265	bayes_pls_golite062009
	3.02967613614595	bayes_pls_golite062009
steroid binding	2.54679035876403	bayes_pls_golite062009
phosphoinositide binding	2.2725849852584	bayes_pls_golite062009
phospholipid binding	2.08170907241909	bayes_pls_golite062009
binding	1.96043183869108	bayes_pls_golite062009
lipid binding	1.8520231230392	bayes_pls_golite062009
cholesterol binding	0.644339278395346	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [889-1283]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKDDRPKISL WAVLKSMVGK DMTRMTLPVT FNEPTSLLQR VAEDLEYSEL LDQAATFEDS  60
   61 TLRTLYVAAF TASSYASTTK RVAKPFNPLL GETFEYSRPD KQYRFFTEQV SHHPPISATW 120
  121 TESPRWDFWG ESFVDTKFNG RSFNVKHLGL WHIKLRPNDN EKEELYTWKK PNNTVIGILI 180
  181 GNPQVDNHGE VNVVNHTTGD HCKLYFKARG WRSSGAYEIT GEVYNKKKQK VWILGGHWNE 240
  241 AIFAKKVVKD GDLSLEKTRT AASAGNGPTD DGTKFLIWKA NDRPEEPFNL TPFAITLNAP 300
  301 QPHLLPWLPP TDTRLRPDQR AMEDGRYDEA GDEKFRVEEK QRAARRKREE NNLEYHPQWF 360
  361 VRDTHPITKA KYWRYTGKYW VKRRDHDLKD CGDIF

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: