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Protein Overview: MAK5

General Information:
Name(s) found: MAK5 / YBR142W [SGD]
Description(s) found:
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  • gi|6319618|ref|NP_009700.1| Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits; Mak5p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S46011 probable pre-mRNA-splicing RNA helicase - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|586550|sp|P38112.1|MAK5_YEAST RecName: Full=ATP-dependent RNA helicase MAK5; AltName: Full=Maintenance of killer protein 5 [NCBI NR]
  • gi|547578|emb|CAA55539.1| YBR1119 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|536442|emb|CAA85100.1| MAK5 [Saccharomyces cerevisiae] [NCBI NR]
  • ATP-dependent RNA helicase MAK5 OS=Saccharomyces cerevisiae GN=MAK5 PE=1 SV=1 [Swiss-Prot]
  • MAK5 ATP-dependent RNA helicase [mips]
  • Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits [SGD]
  • MAK5, Chr II from 528275-530596 [yeast_orfs2]
  • Chr II from 528275-530596 [yeastorf3.fasta]
  • Chr II from 528274-530595 [yeastorf4.fasta]
  • Chr II from 528272-530593 [yeastorf5.fasta]
  • (P38112) ATP-dependent RNA helicase MAK5 [4932.FASTACCERV.txt]
  • MAK5 SGDID:S0000346, Chr II from 528273-530594, Verified ORF [yeastflysequest.fasta]
  • MAK5 SGDID:S0000346, Chr II from 528311-530632, Verified ORF [10112005cervSGD.fasta]
  • Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits [Saccharomyces cerevisiae]gi|547578|emb|CAA55539.1| YBR1119 [Saccharomyces cerevisiae]gi|536 [nrdb_11152004_Chlamydomonas]
  • MAK5 SGDID:S000000346, Chr II from 528311-530632, Verified ORF, "Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MAK5 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ATP-dependent RNA helicase MAK5 (Maintenance of killer protein 5) [nr-271106-contam.fasta]
  • Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits; Mak5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YBR1119 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • ATP-dependent RNA helicase MAK5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAK5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MAK5 SGDID:S000000346, Chr II from 528317-530638, Genome Release 64-1-1, Verified ORF, "Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits" [yeast-030211-contam.fasta]
  • MAK5 SGDID:S000000346, Chr II from 528317-530638, Genome Release 64-2-1, Verified ORF, "Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits" [20141208_orf_trans.fasta]
  • YBR142W SGDID:S000000346, Chr II from 528317-530638, Genome Release 64-1-1, Verified ORF, "Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 773 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    rRNA processing [TASLink to PubMed article]
    ribosomal large subunit assembly [TASLink to PubMed article]
    Molecular Function: ATP-dependent RNA helicase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKRAPQKG KTVTKPQEII VDESKLNWKP VDIPDTLDDF GGFYGLEEID GVDVKVVDGK  60
   61 VTFVTKKDSK VLKDSNKEKV GDDQESVENE SGSDSESELL EFKNLDDIKE GELSAASYSS 120
  121 SDEDEQGNIE SSKLTDPSED VDEDVDEDVL KENVFNKDIN IDDISPVNLP EWTNLAPLSM 180
  181 TILQSLQNLN FLRPTEIQKK SIPVIMQGVD VMGKASTGSG KTLAYGIPIV EKLISNFSQK 240
  241 NKKPISLIFT PTRELAHQVT DHLKKICEPV LAKSQYSILS LTGGLSIQKQ QRLLKYDNSG 300
  301 QIVIATPGRF LELLEKDNTL IKRFSKVNTL ILDEADRLLQ DGHFDEFEKI IKHLLVERRK 360
  361 NRENSEGSSK IWQTLIFSAT FSIDLFDKLS SSRQVKDRRF KNNEDELNAV IQHLMSKIHF 420
  421 NSKPVIIDTN PESKVSSQIK ESLIECPPLE RDLYCYYFLT MFPGTTLIFC NAIDSVKKLT 480
  481 VYLNNLGIPA FQIHSSMTQK NRLKSLERFK QQSAKQKTIN HSNPDSVQLS TVLIASDVAA 540
  541 RGLDIPGVQH VIHYHLPRST DIYIHRSGRT ARAGSEGVSA MICSPQESMG PLRKLRKTLA 600
  601 TKNSVSTDLN SRSTNRKPIK WQNTVPLLPI ETDILSQLRE RSRLAGELAD HEIASNSLRK 660
  661 DDNWLKKAAD ELGIDVDSDE DDISKSNSDT FLLKNKNKKM QKTINKDKVK AMRATLNELL 720
  721 SVPIRKDRRQ KYLTGGLVNL ADNLVKKRGH NSIIGHEKTN ALETLKKKKK RNN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRX1 CIC1 DBP9 DRS1 ECM16 ERB1 FUN12 HAS1 MAK21 MAK5 NIP7 NOC2 NOP12 NOP14 NOP2 NOP4 PRP43 PUF6 RBG1 RLP7 RPA49 RPF1 RPF2 RPL15A RPL5 RPS11A, RPS11B RPS1B RPS4B, RPS4A RPS7A RPS8B, RPS8A URB1 UTP22 YTM1
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) MAK5 MET22
    View Details Gavin AC, et al. (2006) DBP9 MAK21 MAK5 NOP4 RLP7 RSA3 YTM1
    View Details Gavin AC, et al. (2002) ARX1 BEM2 BMS1 BRX1 BUD20 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRT4 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SNU13 SPB1 SPB4 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) CIC1 EBP2 MAK5 MSS116 NOC2 NOP2 NOP58
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BRX1 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CWC2 CWC22 CWC23 DBP10 DBP3 DBP6 DBP7 DBP8 DBP9 DHR2 DRS1 ECM16 ECM2 FAL1 GAR1 HAS1 HCA4 HSH155 ISY1 JIP5 KRI1 KRR1 LSM2 LSM3 LSM4 LSM5 LSM7 LUC7 MAK21 MAK5 MSL1 MTR4 MUD1 MUD2 NAM8 NAN1 NOG2 NOP1 NOP13 NOP15 NOP4 NOP7 NSR1 NUG1 POP1 PRP11 PRP16 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP5 PRP6 PRP8 PRP9 PXR1 RNT1 ROK1 RRP3 RRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNM1 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPB4 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 URB2 UTP10 UTP13 UTP15 UTP4 UTP5 UTP6 UTP8 UTP9 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MAK5 and NOP56 Huh WK, et al. (2003)
    View Data MAK5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..163] MSA 4.338997 View MSA. No confident structure predictions are available.
    2 View Details [164..434] PSI-BLAST 461.228787 Putative DEAD box RNA helicase
    3 View Details [435..597] PSI-BLAST 461.228787 Putative DEAD box RNA helicase
    4 View Details [598..720] PSI-BLAST 9.0 Nucleotide excision repair enzyme UvrB
    5 View Details [721..773] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle