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Protein Overview: MET22

General Information:
Name(s) found: MET22 / YOL064C [SGD]
Description(s) found:
Found 35 descriptions.
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  • Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 357 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: methionine biosynthetic process [TASLink to PubMed article]
    hyperosmotic salinity response [TASLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    sulfate assimilation [TASLink to PubMed article]
    Molecular Function: 3'(2'),5'-bisphosphate nucleotidase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALERELLVA TQAVRKASLL TKRIQSEVIS HKDSTTITKN DNSPVTTGDY AAQTIIINAI  60
   61 KSNFPDDKVV GEESSSGLSD AFVSGILNEI KANDEVYNKN YKKDDFLFTN DQFPLKSLED 120
  121 VRQIIDFGNY EGGRKGRFWC LDPIDGTKGF LRGEQFAVCL ALIVDGVVQL GCIGCPNLVL 180
  181 SSYGAQDLKG HESFGYIFRA VRGLGAFYSP SSDAESWTKI HVRHLKDTKD MITLEGVEKG 240
  241 HSSHDEQTAI KNKLNISKSL HLDSQAKYCL LALGLADVYL RLPIKLSYQE KIWDHAAGNV 300
  301 IVHEAGGIHT DAMEDVPLDF GNGRTLATKG VIASSGPREL HDLVVSTSCD VIQSRNA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MAK5 MET22

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MET22 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] PSI-BLAST 10085.69897 3';5'-adenosine bisphosphatase, PAP phosphatase
    2 View Details [221..357] PSI-BLAST 10085.69897 3';5'-adenosine bisphosphatase, PAP phosphatase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  2.88760626317651 bayes_pls_golite062009
  • phosphatase activity
    		•  2.35747587631464 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.15974571805101 bayes_pls_golite062009
  • catalytic activity
    		•  2.13229228332707 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.56919997723952 bayes_pls_golite062009
  • 3'(2'),5'-bisphosphate nucleotidase activity
    		•  1.47057191917686 bayes_pls_golite062009
  • carbohydrate phosphatase activity
    		•  1.42298284519844 bayes_pls_golite062009
  • fructose 1,6-bisphosphate 1-phosphatase activity
    		•  1.27303304175364 bayes_pls_golite062009
  • binding
    		•  0.836667162379626 bayes_pls_golite062009
  • nucleotidase activity
    		•  0.335234714648046 bayes_pls_golite062009
  • protein binding
    		•  0.0338617836572318 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle