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View Structure Prediction Details

Protein: MET22
Organism: Saccharomyces cerevisiae
Length: 357 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MET22.

Description E-value Query
Range		 Subject
Range
MET22_YEAST - 3'(2'),5'-bisphosphate nucleotidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET2...
MET22 - Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates...
 5.0E-85 [1..357] [1..357]
DPNP1_ARATH - SAL1 phosphatase OS=Arabidopsis thaliana GN=SAL1 PE=1 SV=1
 3.0E-69 [1..355] [1..347]
gi|14268820, gi|... - gi|162459538|ref|NP_001105512.1| diphosphonucleotide phosphatase1 [Zea mays], gi|14268820|gb|AAK5791...
 4.0E-64 [2..356] [6..349]
DPNP_SCHPO - 3'(2'),5'-bisphosphate nucleotidase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=tol1 P...
tol1 - 3'(2'),5'-bisphosphate nucleotidase /inositol-1,4-bisphosphate 1-phosphatase
 6.0E-64 [1..347] [1..337]
DPNP_ORYSA - (Q40639) 3'(2'),5'-bisphosphate nucleotidase (EC 3.1.3.7) (3'(2'),5-bisphosphonucleoside 3'(2')-phos...
 4.0E-62 [2..356] [8..352]
gi|15451579 - gi|15451579|gb|AAK98703.1|AC069158_15 Putative PAP-specific phosphatase [Oryza sativa]
 2.0E-61 [3..354] [85..460]

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Predicted Domain #1
Region A:
Residues: [1-220] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALERELLVA TQAVRKASLL TKRIQSEVIS HKDSTTITKN DNSPVTTGDY AAQTIIINAI  60
   61 KSNFPDDKVV GEESSSGLSD AFVSGILNEI KANDEVYNKN YKKDDFLFTN DQFPLKSLED 120
  121 VRQIIDFGNY EGGRKGRFWC LDPIDGTKGF LRGEQFAVCL ALIVDGVVQL GCIGCPNLVL 180
  181 SSYGAQDLKG HESFGYIFRA VRGLGAFYSP SSDAESWTKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10085.69897
Match: 1ka0A_
Description: 3';5'-adenosine bisphosphatase, PAP phosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 2.88760626317651 bayes_pls_golite062009
phosphatase activity 2.35747587631464 bayes_pls_golite062009
phosphoric ester hydrolase activity 2.15974571805101 bayes_pls_golite062009
catalytic activity 2.13229228332707 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.56919997723952 bayes_pls_golite062009
3'(2'),5'-bisphosphate nucleotidase activity 1.47057191917686 bayes_pls_golite062009
carbohydrate phosphatase activity 1.42298284519844 bayes_pls_golite062009
fructose 1,6-bisphosphate 1-phosphatase activity 1.27303304175364 bayes_pls_golite062009
binding 0.836667162379626 bayes_pls_golite062009
nucleotidase activity 0.335234714648046 bayes_pls_golite062009
protein binding 0.0338617836572318 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [221-357] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVRHLKDTKD MITLEGVEKG HSSHDEQTAI KNKLNISKSL HLDSQAKYCL LALGLADVYL  60
   61 RLPIKLSYQE KIWDHAAGNV IVHEAGGIHT DAMEDVPLDF GNGRTLATKG VIASSGPREL 120
  121 HDLVVSTSCD VIQSRNA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10085.69897
Match: 1ka0A_
Description: 3';5'-adenosine bisphosphatase, PAP phosphatase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle