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Protein Overview: UTP13

General Information:
Name(s) found: UTP13 / YLR222C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 817 amino acids

    Gene Ontology:
    Cellular Component: small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: maturation of SSU-rRNA [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: snoRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLKTSYKGI SLNPIYAGSS AVATVSENGK ILATPVLDEI NIIDLTPGSR KILHKISNED  60
   61 EQEITALKLT PDGQYLTYVS QAQLLKIFHL KTGKVVRSMK ISSPSYILDA DSTSTLLAVG 120
  121 GTDGSIIVVD IENGYITHSF KGHGGTISSL KFYGQLNSKI WLLASGDTNG MVKVWDLVKR 180
  181 KCLHTLQEHT SAVRGLDIIE VPDNDEPSLN LLSGGRDDII NLWDFNMKKK CKLLKTLPVN 240
  241 QQVESCGFLK DGDGKRIIYT AGGDAIFQLI DSESGSVLKR TNKPIEELFI IGVLPILSNS 300
  301 QMFLVLSDQT LQLINVEEDL KNDEDTIQVT SSIAGNHGII ADMRYVGPEL NKLALATNSP 360
  361 SLRIIPVPDL SGPEASLPLD VEIYEGHEDL LNSLDATEDG LWIATASKDN TAIVWRYNEN 420
  421 SCKFDIYAKY IGHSAAVTAV GLPNIVSKGY PEFLLTASND LTIKKWIIPK PTASMDVQII 480
  481 KVSEYTRHAH EKDINALSVS PNDSIFATAS YDKTCKIWNL ENGELEATLA NHKRGLWDVS 540
  541 FCQYDKLLAT SSGDKTVKIW SLDTFSVMKT LEGHTNAVQR CSFINKQKQL ISCGADGLIK 600
  601 IWDCSSGECL KTLDGHNNRL WALSTMNDGD MIVSADADGV FQFWKDCTEQ EIEEEQEKAK 660
  661 LQVEQEQSLQ NYMSKGDWTN AFLLAMTLDH PMRLFNVLKR ALGESRSRQD TEEGKIEVIF 720
  721 NEELDQAISI LNDEQLILLM KRCRDWNTNA KTHTIAQRTI RCILMHHNIA KLSEIPGMVK 780
  781 IVDAIIPYTQ RHFTRVDNLV EQSYILDYAL VEMDKLF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BMS1 DIP2 ECM16 EMG1 IMP3 KRE33 MPP10 NAN1 NOC4 NOP1 NOP56 PWP2 RRP9 SOF1 UTP10 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8
    View Details (MIPS) Mewes HW, et al. (2004) DRS1 GAR1 IFH1 NOP1 NPL3 NSR1 POP1 POP2 RAT1 RNT1 RRP3 SBP1 SNM1 SRD1 UTP10 UTP11 UTP13 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9 YME2
    View Details Krogan NJ, et al. (2006) DIP2 HSV2 PWP2 UTP13 UTP18 UTP21 UTP6 YJL147C
    View Details Gavin AC, et al. (2006) CMS1 DIP2 MRD1 NAN1 NOP58 PNO1 PWP2 ROK1 RRP9 UTP10 UTP13 UTP15 UTP18 UTP21 UTP22 UTP4 UTP6 UTP7 UTP8 UTP9
    View Details Gavin AC, et al. (2002) ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LTV1 MPP10 MRD1 MVD1 NAN1 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 PAP1 PFS2 PNO1 PRE6 PRE9 PRP43 PTA1 PTI1 PWP2 RCL1 REF2 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SOF1 SRO9 TIF1, TIF2 TSR1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YOR059C YSH1
    View Details Ho Y, et al. (2002) ADK1 ARP10 ATG18 CKA1 CKA2 CKB1 CKB2 CLU1 COP1 DIP2 DIP5 ESL2 FET4 GPH1 HHF1, HHF2 HIR2 HTA1 HTB1 KAP114 KRE33 KRI1 LCP5 MUM2 NAN1 NAP1 NOP1 NOP4 NOP56 NOP7 PGM2 PNO1 POR1 PRP11 PRP40 PTC5 PWP2 RET1 REX2 RPC82 RPO31 RRP5 SAP155 SEC27 SHM2 SIT4 SPT16 SRV2 SSK2 TFP1 THI22 TIF4631 TIP41 UBP15 UTP10 UTP11 UTP13 UTP14 UTP18 UTP21 UTP22 UTP30 UTP6 YGR210C YGR250C YHR020W
    View Details Qiu et al. (2008) BFR2 BUD21 CBF5 DBP3 DBP6 DBP8 DIP2 DRS1 ENP1 ERB1 GAR1 JIP5 LCP5 MAK5 MTR4 NAN1 NOP1 NOP12 NOP13 NOP14 NOP15 NOP4 NSR1 NUG1 PRP43 PWP2 PXR1 RRP3 RRP5 RRP9 SAS10 SBP1 SOF1 SPB4 SSF1 UTP10 UTP11 UTP13 UTP14 UTP15 UTP18 UTP20 UTP22 UTP4 UTP5 UTP6 UTP7 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data UTP13 and NOP56 Huh WK, et al. (2003)
    View Data UTP13 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] Pcons 3.75 Tup1, C-terminal domain
    2 View Details [132..178] Pfam 5.420216 WD domain, G-beta repeat No confident structure predictions are available.
    3 View Details [179..225] Pfam 5.142668 WD domain, G-beta repeat No confident structure predictions are available.
    4 View Details [226..315] deduced N/A No confident structure predictions are available.
    5 View Details [316..645] PSI-BLAST 179.758605 beta1-subunit of the signal-transducing G protein heterotrimer
    6 View Details [646..764] PSI-BLAST 74.218487 Groucho/tle1, C-terminal domain
    7 View Details [765..817] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • snoRNA binding
    		•  6.03079504484743 bayes_pls_golite062009
    		• 4.49063274868921 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  4.33124151198369 bayes_pls_golite062009
  • actin binding
    		•  3.86142918698875 bayes_pls_golite062009
  • RNA binding
    		•  3.77273677738815 bayes_pls_golite062009
  • myosin II binding
    		•  3.56132510021228 bayes_pls_golite062009
  • GTPase activity
    		•  3.23750443966606 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K4 specific)
    		•  2.299832037975 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  2.10926890165617 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10348788067437 bayes_pls_golite062009
  • actin filament binding
    		•  2.0735069176589 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.00420268007946 bayes_pls_golite062009
  • dynactin binding
    		•  1.99805820148456 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  1.95039718468175 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.53722103498827 bayes_pls_golite062009
  • DNA binding
    		•  1.53482914288832 bayes_pls_golite062009
  • structural molecule activity
    		•  1.47097979074281 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • receptor activity
    		•  1.12819778129653 bayes_pls_golite062009
  • mRNA binding
    		•  1.05053985350578 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • myosin binding
    		•  0.989691178611801 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • signal transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • protein transporter activity
    		•  0.964340340346761 bayes_pls_golite062009
  • transcription factor activity
    		•  0.897833210520351 bayes_pls_golite062009
  • kinase activity
    		•  0.807669232329985 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.805273887494167 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • transcription activator activity
    		•  0.724420384084538 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.634547834947756 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.624053529462119 bayes_pls_golite062009
  • protein kinase activity
    		•  0.544118712921054 bayes_pls_golite062009
  • transcription factor binding
    		•  0.469377587704245 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.443846546939402 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.245000508226811 bayes_pls_golite062009
  • transferase activity
    		•  0.217164597663731 bayes_pls_golite062009
  • ligase activity
    		•  0.20682813699621 bayes_pls_golite062009
  • histone binding
    		•  0.166694897714113 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0803897416817422 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.0676565515282608 bayes_pls_golite062009
  • receptor binding
    		•  0.0390635451962911 bayes_pls_golite062009
  • kinase binding
    		•  0.0366162235750993 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00858004043229577 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle