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Protein Overview: NOP6

General Information:
Name(s) found: NOP6 / YDL213C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 225 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    Biological Process: rRNA processing [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSEEDKKLT KKQLKAQQFR KSKEEKDQEK DVKKEQAPEG KRPNSAAGND GEEPVKKKRK  60
   61 TRRGRGGKGK NGKKGNRFIV FVGSLPRDIT AVELQNHFKN SSPDQIRLRA DKGIAFLEFD 120
  121 ADKDRTGIQR RMDIALLQHG TLLKEKKINV ELTVGGGGNS QERLEKLKNK NIKLDEERKE 180
  181 RLTKMINDGN QKKIAKTTAT AAQTSGTDNK PVPAGIHPDR AKLLK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CBF5 KRI1 KRR1 NOP6 UTP20
    View Details Krogan NJ, et al. (2006) COQ10 DBP3 DSE4 GAR1 KRI1 KRR1 NHP2 NOP10 NOP6 YCR016W YDR381C-A
    View Details Gavin AC, et al. (2006) BMS1 BUD21 ENP2 ESF1 KRR1 MVD1 NOP6 RPL26B
    View Details Gavin AC, et al. (2002) AAR2 ADE4 ASC1 BFR2 BMS1 BRX1 BUD21 CBF5 CFT2 CIC1 CKA1 CKA2 CKB1 CKB2 CMS1 DBP8 DBP9 DIA4 DIM1 DIP2 DIS3 DRS1 ECM16 ECM29 EMG1 ENP1 ENP2 ERB1 ERO1 ESF1 ESF2 FAP7 FIP1 FUN12 GAR1 GCN1 GLC7 HAS1 HCA4 HHF1, HHF2 HSL1 HTA2 IMP3 IMP4 KRE33 KRR1 LCP5 LHP1 LTV1 MAK21 MDN1 MIS1 MPP10 MRD1 MRP7 MVD1 NAN1 NHP2 NIP1 NOB1 NOC2 NOC4 NOG1 NOP1 NOP12 NOP14 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NUG1 PAP1 PFS2 PNO1 POL2 PRE6 PRE9 PRP4 PRP43 PTA1 PTI1 PUF6 PWP2 RCL1 REF2 RLP7 RML2 RNA14 ROK1 RPP2B RRP12 RRP7 RRP9 RTG2 SAM1 SCL1 SEC21 SLX9 SMB1 SNU114 SNU66 SOF1 SRO9 TIF1, TIF2 TIF4631 TIF4632 TSR1 URB1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YMR310C YOR059C YSH1 YTM1
    View Details Ho Y, et al. (2002) CBF5 CBP2 CCM1 CDC33 CIC1 DBP7 DIS3 DRS1 EAF3 ENP2 ERB1 FIP1 GBP2 GLC7 HAS1 HMO1 HPR1 HTB1 HTB2 HXT6 IMD1 IMD3 ISA1 KAP95 KOG1 KRE33 KRI1 KRR1 MES1 MFT1 MGM101 MNP1 MSS116 NAM8 NET1 NOC2 NOP12 NOP2 NOP58 NOP6 NOP7 NPL3 NSR1 NUG1 NUP1 NUP2 NUP60 PAP1 PCT1 PET127 PMA1 PMA2 POL5 PPZ2 PRP43 PUF6 PWP1 REB1 REG1 RLI1 RNT1 RPF2 RRP12 RRP4 RRP43 RRP5 RRP6 RSE1 RTT103 RVB1 SDS22 SIF2 SIN3 SNF4 SNU56 SRP1 STO1 THO2 TIF1, TIF2 TIF4631 TIF6 TRA1 TSR1 UME1 URB1 URB2 UTP10 UTP20 YGR130C YPP1 YPR090W YRA1 YTM1
    View Details Qiu et al. (2008) NOP6 PXR1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen NOP6 RRT5 2 Uetz P, et al. (2000)
    View Screen NOP6 TGL2 1 Unpublished Fields Lab Data
    View Screen NOP6 SNF11 1 Unpublished Fields Lab Data
    View Screen NOP6 YDR102C 1 Unpublished Fields Lab Data
    View Screen NOP6 NUP49 1 Unpublished Fields Lab Data
    View Screen NOP6 YAP1802 1 Unpublished Fields Lab Data
    View Screen NOP6 POT1 1 Unpublished Fields Lab Data
    View Screen NOP6 YJL206C 1 Unpublished Fields Lab Data
    View Screen NOP6 CTF18 1 Unpublished Fields Lab Data
    View Screen NOP6 NAM9 1 Unpublished Fields Lab Data
    View Screen NOP6 PGA2 1 Unpublished Fields Lab Data
    View Screen NOP6 RTS2 1 Unpublished Fields Lab Data
    View Screen NAF1 NOP6 1 Hazbun TR, et al. (2003)
    View Screen NOP6 RTG3 1 Unpublished Fields Lab Data
    View Screen NOP6 YCR022C 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NOP6 and NOP56 Huh WK, et al. (2003)
    View Data NOP6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..225] ORFEUS 10.13 Nucleolin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  3.32086587430292 bayes_pls_golite062009
  • binding
    		•  2.84652855524974 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.07488701626356 bayes_pls_golite062009
    		• 1.23676130179002 bayes_pls_golite062009
  • structural molecule activity
    		•  1.11870738570663 bayes_pls_golite062009
  • protein binding
    		•  0.826837409443725 bayes_pls_golite062009
  • mRNA binding
    		•  0.132944695780323 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle