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Protein Overview: PRE6

General Information:
Name(s) found: PRE6 / YOL038W [SGD]
Description(s) found:
Found 43 descriptions.
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  • Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 254 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    proteasome core complex, alpha-subunit complex [IPILink to PubMed article][ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: endopeptidase activity [TASLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGYDRALSI FSPDGHIFQV EYALEAVKRG TCAVGVKGKN CVVLGCERRS TLKLQDTRIT  60
   61 PSKVSKIDSH VVLSFSGLNA DSRILIEKAR VEAQSHRLTL EDPVTVEYLT RYVAGVQQRY 120
  121 TQSGGVRPFG VSTLIAGFDP RDDEPKLYQT EPSGIYSSWS AQTIGRNSKT VREFLEKNYD 180
  181 RKEPPATVEE CVKLTVRSLL EVVQTGAKNI EITVVKPDSD IVALSSEEIN QYVTQIEQEK 240
  241 QEQQEQDKKK KSNH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BLM10 GNA1 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 SCL1 URH1 YCR076C
    View Details (MIPS) Mewes HW, et al. (2004) PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 SCL1 UMP1
    View Details Krogan NJ, et al. (2006) ACK1 CIN8 DCG1 GNA1 MCM6 MLP1 PMD1 PMT4 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RFT1 SCL1 SGA1 SNQ2 TOS8 UMP1 YCR076C YDR179W-A YJL132W YKR070W YLR211C YLR290C
    View Details Gavin AC, et al. (2006) PRE10 PRE2 PRE3 PRE6 PRE8 PUP3 SCL1
    View Details Gavin AC, et al. (2002) ADE4 ASC1 BFR2 BLM10 BMS1 BRX1 BUD21 CBF5 CDC55 CDC6 CFT2 CIN1 CKA1 CKA2 CKB1 CKB2 CMS1 DAM1 DBP8 DBP9 DIA4 DIM1 DIP2 DIS3 ECM16 ECM29 EMG1 ENP1 ENP2 ERG13 ERO1 ESF1 ESF2 EST3 FAP7 FIP1 GCN1 GFA1 GLC7 GUS1 HAS1 HCA4 HHF1, HHF2 HOS2 HOS4 HSL1 HTA2 IML1 IMP3 IMP4 INO4 KAP95 KEL1 KRE33 KRR1 LCP5 LTE1 LTV1 LYS12 MDS3 MLH2 MPP10 MRD1 MVD1 MYO5 NAN1 NAS6 NOB1 NOC2 NOC4 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 NUD1 PAP1 PDA1 PDB1 PFK1 PFS2 PGK1 PNO1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PRP43 PSE1 PTA1 PTI1 PUP1 PUP2 PUP3 PWP2 RCL1 REF2 RGR1 RML2 RNA14 ROK1 RPN10 RPN11 RPN12 RPN13 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPP2B RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRD2 RRP12 RRP7 RRP9 RTG2 RTS1 RTS3 SAM1 SCL1 SEC21 SET3 SIF2 SLX9 SNT1 SOF1 SPA2 SRO9 SRP1 TDH2 TDH3 TEF4 TIF1, TIF2 TPD3 TSR1 UBP6 ULP1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YBL104C YFL006W YMR310C YOR059C YOR1 YRA1 YSH1 ZDS1 ZDS2
    View Details Ho Y, et al. (2002) ADD66 PBA1 PRE1 PRE10 PRE2 PRE3 PRE5 PRE6 PRE7 PRE8 PRE9 PUP2 PUP3 SCL1 YHR033W
    View Details Qiu et al. (2008) PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RPN1 RPN10 RPN11 RPN13 RPN2 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SCL1 UMP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRE6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..254] PSI-BLAST 1391.0 Proteasome alpha subunit (non-catalytic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endopeptidase activity
    		•  6.91642761177919 bayes_pls_golite062009
  • peptidase activity
    		•  6.84511694091156 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.5973571808298 bayes_pls_golite062009
  • hydrolase activity
    		•  4.47652590304822 bayes_pls_golite062009
  • threonine-type endopeptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • threonine-type peptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • binding
    		•  1.75265921676176 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.39216781236247 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle