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Protein Overview: PDC1

General Information:
Name(s) found: PDC1 / YLR044C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 563 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: pyruvate metabolic process [TASLink to PubMed article]
    glucose catabolic process to ethanol [TASLink to PubMed article]
    Molecular Function: pyruvate decarboxylase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEITLGKYL FERLKQVNVN TVFGLPGDFN LSLLDKIYEV EGMRWAGNAN ELNAAYAADG  60
   61 YARIKGMSCI ITTFGVGELS ALNGIAGSYA EHVGVLHVVG VPSISAQAKQ LLLHHTLGNG 120
  121 DFTVFHRMSA NISETTAMIT DIATAPAEID RCIRTTYVTQ RPVYLGLPAN LVDLNVPAKL 180
  181 LQTPIDMSLK PNDAESEKEV IDTILALVKD AKNPVILADA CCSRHDVKAE TKKLIDLTQF 240
  241 PAFVTPMGKG SIDEQHPRYG GVYVGTLSKP EVKEAVESAD LILSVGALLS DFNTGSFSYS 300
  301 YKTKNIVEFH SDHMKIRNAT FPGVQMKFVL QKLLTTIADA AKGYKPVAVP ARTPANAAVP 360
  361 ASTPLKQEWM WNQLGNFLQE GDVVIAETGT SAFGINQTTF PNNTYGISQV LWGSIGFTTG 420
  421 ATLGAAFAAE EIDPKKRVIL FIGDGSLQLT VQEISTMIRW GLKPYLFVLN NDGYTIEKLI 480
  481 HGPKAQYNEI QGWDHLSLLP TFGAKDYETH RVATTGEWDK LTQDKSFNDN SKIRMIEIML 540
  541 PVFDAPQNLV EQAKLTAATN AKQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADH1 EFT2, EFT1 ENO1 FBA1 HSC82 PDC1 TDH2 TPI1 YEF3
    View Details Gavin AC, et al. (2006) PDC1 PTM1
    View Details Gavin AC, et al. (2002) ADH1 AHA1 ATP11 BNI1 CAF130 CAF40 CCR4 CCT4 CCT6 CDC36 CDC39 CDC48 CHC1 COG8 COP1 CRM1 DHH1 DOA1 ENO2 ESC8 FAR11 FAR3 FAS2 FBA1 GCD1 GCD11 GCD2 GCD6 GCD7 GCN1 GCN3 GIN4 GPM1 GUT1 HFM1 HIS4 HMO1 HSC82 HSP42 IOC3 IST1 ISW1 ITC1 KAP114 KAP123 KCC4 MIR1 MOT1 MOT2 MRPS28 NOT3 NOT5 NPL4 NPL6 NSL1 PBP2 PDC1 PEP4 PFK2 PGI1 POL1 POL12 POP2 PRI1 PRI2 PRO1 PRP11 RAD1 RAD10 RAD16 RAI1 REG1 RIM1 ROM2 RPA135 RPA190 RPC40 RPN9 RPO31 RPT5 RRP40 RRP46 RSC2 RSC4 RSC58 RSC6 RSC8 RVB2 SAM1 SEC27 SHP1 SIN3 SNT2 SPT15 SSE2 SUI2 SUI3 TAF1 TAF5 TAF6 TAT1 TDH3 TFC7 TFP1 TPI1 TUB3 UFD1 VMA4 VPS1 WRS1 XKS1 YDR049W YEF3 YHR020W YMR315W YRA1
    View Details Qiu et al. (2008) PDC1 PDC5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run KOG1 No Comments Reinke A, et al. (2004)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ASF1 3906: TAP-tagged Green EM, et al (2005)
    View Run ASF1 3908: TAP-tagged, includes hir2(delta) in background Green EM, et al (2005)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #22 Asynchronous Prep2-IMAC Phosphopeptide enrichment B1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #28 Asynchronous Prep5-TiO2 Phosphopeptide Enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #16 Mitotic-New search criteria Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #05 Alpha Factor Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #07 Alpha Factor Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #09 Alpha Factor Prep4-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run None Entered #18 Mitotic Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PDC1 Huh WK, et al. (2003)
    View Data PDC1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..188] PSI-BLAST 10166.0 Pyruvate decarboxylase
    2 View Details [189..353] PSI-BLAST 10166.0 Pyruvate decarboxylase
    3 View Details [354..563] PSI-BLAST 10166.0 Pyruvate decarboxylase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.69

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle