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Protein Overview: RPF2

General Information:
Name(s) found: RPF2 / YKR081C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 344 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    ribosomal large subunit assembly [IMPLink to PubMed article][IPILink to PubMed article]
    processing of 27S pre-rRNA [IMPLink to PubMed article]
    Molecular Function: 5S rRNA binding [IPILink to PubMed article]
    7S RNA binding [IPILink to PubMed article]
    rRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRTVKPKNA RAKRALVKRE AKLVENVKQA LFIPGQSCNK NLHDIMVDLS ALKKPDMKRF  60
   61 NRKNDIHPFE DMSPLEFFSE KNDCSLMVLM TSSKKRKNNM TFIRTFGYKI YDMIELMVAD 120
  121 NFKLLSDFKK LTFTVGLKPM FTFQGAAFDT HPVYKQIKSL FLDFFRGEST DLQDVAGLQH 180
  181 VISMTIQGDF QDGEPLPNVL FRVYKLKSYK SDQGGKRLPR IELVEIGPRL DFKIGRIHTP 240
  241 SPDMVTEAHK KPKQLEMKTK KNVELDIMGD KLGRIHMGKQ DLGKLQTRKM KGLKSKFDQG 300
  301 TEEGDGEVDE DYEDEASYSD DGQEYEEEFV SATDIEPSAK RQKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRX1 CIC1 DBP10 DRS1 EBP2 ESF1 FUN12 GAR1 HAS1 HCA4 IMD3 KRE33 KRI1 LOC1 LSP1 MAK21 MAK5 MRT4 MSS116 NOC2 NOC3 NOG1 NOG2 NOP12 NOP15 NOP2 NOP53 NOP56 NOP58 NOP7 NSA2 NUG1 PUF6 PWP1 RPA49 RPF2 RPL11B RPL15A RPL1A, RPL1B RPL20A RPL2A, RPL2B RPL36A RPL4A RPL5 RPL6A RPL8B RPS11A, RPS11B RPS16B, RPS16A RPS4B, RPS4A RRP12 RRP5 RVS161 TIF6 UTP22 YCR016W YNL208W
    View Details Krogan NJ, et al. (2006) ALG5 BRE5 CSN12 CUP2 DBP7 LUG1 MET10 MSC7 MSE1 NOP53 NPY1 PBP4 RPF2 RRS1 SAS5 UME6 YGR126W YHR127W YPR045C YRA1
    View Details Gavin AC, et al. (2006) ARX1 BUD20 FPR4 IPI3 MRT4 NIP7 NOG1 NOG2 NOP2 NSA2 NUG1 RIX1 RPF2 RSA4 SDA1 TIF6
    View Details Gavin AC, et al. (2002) ARX1 BEM2 BMS1 BRX1 BUD20 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRT4 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SNU13 SPB1 SPB4 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) AAC3 ACO1 ADH2 AIM46 ARE1 CBF5 CBP2 CDC16 CDC33 CIC1 CKA1 CKA2 CKB1 CKB2 CYS4 DBP10 DBP7 DNL4 DRS1 EBP2 ECM10 ELA1 ENP2 ERB1 ESF1 ESF2 EST1 FET4 FPR3 FPR4 FUN12 GDE1 GND1 GRS1 GSP1 HAS1 HHF1, HHF2 HSH49 HTA1 HTB1 IMD2 IMD3 IMD4 KAP95 KGD1 KRE33 KRI1 KRR1 LAA1 LHP1 LOC1 LSP1 MAG2 MAK16 MAM33 MES1 MGM101 MKT1 MMS4 MNP1 MRM1 MSC3 MSS116 MUS81 NHP2 NOC2 NOG1 NOP1 NOP12 NOP15 NOP2 NOP4 NOP58 NOP6 NOP7 NPL3 NSA1 NUG1 OYE2 PDC6 PDI1 PET127 PIL1 PMA1 POL30 PUF6 PWP1 RAD53 RLI1 RPC10 RPF2 RRP1 RRP12 RRP15 RRP5 RRT6 SEC23 SPB1 SPT2 SRP1 SSF1 STE23 SUP45 TAF14 TIF1, TIF2 TIF4631 TIF4632 TIF6 TIS11 TPT1 TSR1 UBI4 URB1 URB2 UTP10 UTP22 UTP7 YAK1 YCR087W YDR102C YEN1 YER077C YHB1 YRA1 YTM1
    View Details Qiu et al. (2008) BRX1 DBP3 GAR1 HCA4 KRE33 KRR1 MRT4 NOP4 NUG1 PXR1 RCL1 RLP7 RPF2 RPL27A RRP1 SSF1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RPF2 and NOP56 Huh WK, et al. (2003)
    View Data RPF2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..262] Pfam 168.022276 No description for PF03679 was found. No confident structure predictions are available.
    2 View Details [263..344] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • aminoacyl-tRNA ligase activity
    		•  3.51611427841435 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  3.51602790171379 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  3.51602790171379 bayes_pls_golite062009
  • ligase activity
    		•  2.39787140469438 bayes_pls_golite062009
  • binding
    		•  1.79619860046184 bayes_pls_golite062009
  • proline-tRNA ligase activity
    		•  1.61792117479721 bayes_pls_golite062009
  • catalytic activity
    		•  0.853948963582441 bayes_pls_golite062009
  • protein binding
    		•  0.668055564043996 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle