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Protein Overview: HTB2

General Information:
Name(s) found: HTB2 / YBL002W [SGD]
Description(s) found:
Found 38 descriptions.
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  • Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 131 amino acids

    Gene Ontology:
    Cellular Component: nuclear nucleosome [TASLink to PubMed article]
    Biological Process: chromatin assembly or disassembly [TASLink to PubMed article]
    Molecular Function: DNA binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSAAEKKPA SKAPAEKKPA AKKTSTSVDG KKRSKVRKET YSSYIYKVLK QTHPDTGISQ  60
   61 KSMSILNSFV NDIFERIATE ASKLAAYNKK STISAREIQT AVRLILPGEL AKHAVSEGTR 120
  121 AVTKYSSSTQ A

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) HHF1, HHF2 HHT1, HHT2 HTA1 HTA2 HTB1 HTB2
    View Details Krogan NJ, et al. (2006) ABF2 ARG82 CKI1 CMR1 HHF1, HHF2 HTA1 HTA2 HTB1 HTB2 NUP188 PPH3 PSY2 PSY4 RRD1 SLX5 SLX8 SPT5 STP1 TOP2
    View Details Ho Y, et al. (2002) ADH2 AFG2 AIM21 ALB1 ARX1 ATP3 BBC1 BEM2 BUD20 BUD3 CBF5 CBP2 CCM1 CDC33 CDC53 CIC1 CKA1 CKB1 CKB2 CLU1 COF1 COP1 COR1 CPR1 DBP2 DBP7 DUF1 EDE1 EGD1 EHD3 ENP2 ERB1 FKH2 FOL2 FPR3 FYV4 GAC1 GBP2 GND1 GPI15 GRR1 GSY2 HAS1 HHF1, HHF2 HHT1, HHT2 HMO1 HOT1 HTA1 HTA2 HTB1 HTB2 HTZ1 HYP2 IGO1 IMD1 IMD3 INO4 INO80 IPI3 ISA1 KNS1 KRE33 KRI1 LHP1 LHS1 LSM2 MAG1 MAM33 MDH1 MGM101 MIH1 MKT1 MNP1 MRPS16 MSS116 NIP1 NIP7 NMD3 NOB1 NOC2 NOG1 NOP12 NOP13 NOP2 NOP4 NOP56 NOP6 NOP7 NPL3 NSA2 NUG1 OYE2 PDC5 PDC6 PDI1 PET127 PFK1 POB3 POL5 POR1 PRP43 PSE1 PSH1 PUF6 PWP1 QCR2 RAD16 RAD7 RIX1 RLI1 RLP24 RPC19 RPG1 RRP12 RRP5 RSM24 RSM25 SAH1 SCP160 SES1 SHP1 SIN3 SKP1 SPT16 SRV2 SSF1 SYP1 TEF4 TIF34 TIF35 TIF4631 TIF6 TMA29 TRA1 TSA2 TSR1 UBI4 URB1 URB2 UTP10 UTP20 UTP4 YBL044W YER084W YFL006W YGR054W YGR067C YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) HHF1, HHF2 HHT1, HHT2 HTA1 HTA2 HTB1 HTB2 PCC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIF2 No Comments Cheeseman IM, et al. (2002)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HTB2 and NOP56 Huh WK, et al. (2003)
    View Data HTB2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] PSI-BLAST 447.9794 Histone H2B

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.73700145395396 bayes_pls_golite062009
  • DNA binding
    		•  1.04127970884713 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.86554830065808 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.57702121108343 bayes_pls_golite062009
  • protein binding
    		•  0.260428734715028 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle