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Protein Overview: HEF3

General Information:
Name(s) found: HEF3 / YNL014W [SGD]
Description(s) found:
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  • gi|6324314|ref|NP_014384.1| Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; Hef3p [Saccharomyce [NCBI NR]
  • pir||S62926 probable membrane protein YNL014w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1706591|sp|P53978.2|EF3B_YEAST RecName: Full=Elongation factor 3B; Short=EF-3B; AltName: Full=Translation elongation factor 3B; AltName: Full=Homolog of EF-3 [NCBI NR]
  • gi|1301836|emb|CAA95874.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Elongation factor 3B OS=Saccharomyces cerevisiae GN=HEF3 PE=1 SV=2 [Swiss-Prot]
  • HEF3 Translation elongation factor eEF3 homolog [mips]
  • Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells [SGD]
  • HEF3, Chr XIV from 606315-609449 [yeast_orfs2]
  • Chr XIV from 606315-609449 [yeastorf3.fasta]
  • HEF3 SGDID:S0004959, Chr XIV from 606317-609451, Verified ORF [yeastflysequest.fasta]
  • HEF3 SGDID:S0004959, Chr XIV from 606318-609452, Verified ORF [10112005cervSGD.fasta]
  • Hef3p [Saccharomyces cerevisiae]gi|1301836|emb|CAA95874.1| unnamed protein product [Saccharomyces cerevisiae]gi|2119783|pir||S62926 probable membrane protein YNL014w - yeast (Saccharomyces cerevisiae)gi|1706591|sp|P53978|EF3B_YEAST Elongation factor 3B [nrdb_11152004_Chlamydomonas]
  • HEF3 SGDID:S000004959, Chr XIV from 606320-609454, Verified ORF, "Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zin [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; Hef3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Elongation factor 3B (EF-3B) (Translation elongation factor 3B) (Homolog of EF-3) [nr-271106-contam.fasta]
  • HEF3 SGDID:S000004959, Chr XIV from 606321-609455, Verified ORF, "Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zin [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • HEF3 SGDID:S000004959, Chr XIV from 606320-609454, Verified ORF, "Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • HEF3 SGDID:S000004959, Chr XIV from 606321-609455, Verified ORF, "Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells" [SGDyeast.20101221.fasta]
  • Elongation factor 3B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEF3 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • HEF3 SGDID:S000004959, Chr XIV from 606319-609453, Genome Release 64-1-1, Verified ORF, "Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells" [yeast-030211-contam.fasta]
  • HEF3 SGDID:S000004959, Chr XIV from 606319-609453, Genome Release 64-2-1, Verified ORF, "Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YNL014W SGDID:S000004959, Chr XIV from 606319-609453, Genome Release 64-1-1, Verified ORF, "Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1044 amino acids

    Gene Ontology:
    Cellular Component: cytosolic ribosome [IPI]
    Biological Process: translational elongation [IGILink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]
    translation elongation factor activity [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSQQSITV LEELFRKLET ATSETREGIS SELSSFLNGN IIEHDVPEVF FDEFQKAIQS  60
   61 KQKALNTLGA VAYIANETNL SPSVEPYIVA TVPSVCSKAG SKDNDVQLAA TKALKAIASA 120
  121 VNPVAVKALL PHLIHSLETS NKWKEKVAVL EVISVLVDAA KEQIALRMPE LIPVLSESMW 180
  181 DTKKGVKEAA TTTITKATET VDNKDIERFI PKLIECIANP NEVPETVHLL GATTFVAEVT 240
  241 PATLSIMVPL LSRGLAERET SIKRKAAVII DNMCKLVEDP QVVAPFLGKL LPGLKNNFAT 300
  301 IADPEAREVT LKALKTLRRV GNVGEDDVLP EISHAGDVST TLGVIKELLE PEKVAPRFTI 360
  361 VVEYIAAIAA NLIDERIIDQ QTWFTHVTPY MTIFLHEKTA KEILDDFRKR AVDNIPVGPN 420
  421 FQDEEDEGED LCNCEFSLAY GAKILLNKTQ LRLKRGRRYG LCGPNGAGKS TLMRSIANGQ 480
  481 VDGFPTQDEC RTVYVEHDID NTHSDMSVLD FVYSGNVGTK DVITSKLKEF GFSDEMIEMP 540
  541 IASLSGGWKM KLALARAVLK DADILLLDEP TNHLDTVNVE WLVNYLNTCG ITSVIVSHDS 600
  601 GFLDKVCQYI IHYEGLKLRK YKGNLSEFVQ KCPTAQSYYE LGASDLEFQF PTPGYLEGVK 660
  661 TKQKAIVKVS NMTFQYPGTT KPQVSDVTFQ CSLSSRIAVI GPNGAGKSTL INVLTGELLP 720
  721 TSGEVYTHEN CRIAYIKQHA FAHIESHLDK TPSEYIQWRF QTGEDRETMD RANRQINEND 780
  781 AEAMNKIFKI EGTPRRVAGI HSRRKFKNTY EYECSFLLGE NIGMKSERWV PMMSVDNAWL 840
  841 PRGELIESHS KMVAEIDMKE ALASGQFRAL TRKEIELHCA MLGLDSELVS HSRIRGLSGG 900
  901 QKVKLVLAAC TWQRPHLIVL DEPTNYLDRD SLGALSKALK AFEGGVIIIT HSAEFTKNLT 960
  961 DEVWAVKDGK MTPSGHNWVA GQGAGPRIEK KEEEGDKFDA MGNKINSGKK KSKLSSAELR1020
 1021 KKKKERMKKK KEMGDEYVSS DEDF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AAC3 AAT2 ACH1 ACO1 ADE5,7 ADK1 AFR1 AHA1 AHP1 ARC1 ARF1 ARO1 ATP3 ATP5 ATP7 BCY1 BUD32 CAR2 CDC14 CDC15 CDC33 CDC60 CLU1 COF1 COR1 CPA2 CPR1 CPR6 CRM1 CYR1 CYS4 DBP8 DEF1 DIA4 DPM1 EGD1 ERG13 ERG6 ESS1 FAA1 FPR1 FRS2 FUR1 GDE1 GLC7 GND1 GND2 GPG1 GRX1 GRX3 GRX4 GUS1 HEF3 HHF1, HHF2 HMS1 HOR2 HSP104 HTB1 HXT6 HXT7 IDP2 IMD2 IMD4 KAE1 KGD1 KIP3 LHS1 LRO1 LSP1 MCR1 MDH1 MDN1 MET6 MGE1 MGT1 MTC5 NPA3 NTF2 OLA1 OYE2 PFK1 PGM2 PHO81 PIL1 PRM2 PRO2 PTC6 PUP2 PYC1 RAD1 RFA3 RFC2 RHR2 RIP1 RNH202 RNR1 RNR2 RPB3 RPN1 RPN5 RPN6 RPO21 RPT1 RSN1 SAH1 SCP160 SEC18 SEC23 SEC26 SEC27 SEC53 SEN15 SES1 SGO1 SNF4 SNU13 SOD1 SOF1 SPE3 SPT5 SRP1 SSZ1 TEF4 TFG1 THI22 THS1 TIF1, TIF2 TMA19 TMA29 TOM1 TPS1 TSA2 UBA1 UBR1 URA7 UTP22 VAS1 VMA4 VMA5 WTM1 YDL086W YHR033W YJR141W YNK1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run IPL1 No Comments Cheeseman IM, et al. (2002)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #28 Asynchronous Prep5-TiO2 Phosphopeptide Enrichment Keck JM, et al. (2011)
    View Run MLP2 #05 Alpha Factor Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #07 Alpha Factor Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HEF3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..321] MSA 6.11895 View MSA. No confident structure predictions are available.
    2 View Details [322..418] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [419..645] PSI-BLAST 93.383689 ATP-binding subunit of the histidine permease
    4 View Details [646..1044] MSA 7.425969 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle