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Protein Overview: CCT2

General Information:
Name(s) found: CCT2 / YIL142W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 527 amino acids

    Gene Ontology:
    Cellular Component: chaperonin-containing T-complex [IPILink to PubMed article][TASLink to PubMed article]
    cytoskeleton [TASLink to PubMed article]
    cytoplasm [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: cytoskeleton organization [TASLink to PubMed article]
    protein folding [TASLink to PubMed article]
    Molecular Function: unfolded protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVQIFGDQV TEERAENARL SAFVGAIAVG DLVKSTLGPK GMDKLLQSAS SNTCMVTNDG  60
   61 ATILKSIPLD NPAAKVLVNI SKVQDDEVGD GTTSVTVLSA ELLREAEKLI DQSKIHPQTI 120
  121 IEGYRLASAA ALDALTKAAV DNSHDKTMFR EDLIHIAKTT LSSKILSQDK DHFAELATNA 180
  181 ILRLKGSTNL EHIQIIKILG GKLSDSFLDE GFILAKKFGN NQPKRIENAK ILIANTTLDT 240
  241 DKVKIFGTKF KVDSTAKLAQ LEKAEREKMK NKIAKISKFG INTFINRQLI YDYPEQLFTD 300
  301 LGINSIEHAD FEGVERLALV TGGEVVSTFD EPSKCKLGEC DVIEEIMLGE QPFLKFSGCK 360
  361 AGEACTIVLR GATDQTLDEA ERSLHDALSV LSQTTKETRT VLGGGCAEMV MSKAVDTEAQ 420
  421 NIDGKKSLAV EAFARALRQL PTILADNAGF DSSELVSKLR SSIYNGISTS GLDLNNGTIA 480
  481 DMRQLGIVES YKLKRAVVSS ASEAAEVLLR VDNIIRARPR TANRQHM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CCT2 CCT3 CCT5 CCT6 TCP1
    View Details (MIPS) Mewes HW, et al. (2004) CCT2 CCT3 CCT4 CCT5 CCT6 CCT7 CCT8 TCP1
    View Details Krogan NJ, et al. (2006) CCT2 CCT4 CCT6
    View Details Gavin AC, et al. (2006) CCT2 CCT7 PLP2 VID27
    View Details Gavin AC, et al. (2002) ACC1 AVT4 BEM2 CCT2 CDC25 FAB1 FYV8 HRK1 MDS3 MIA40 MRPL3 SAP155 SAP185 SAP190 SIT4 SWT21 THI3
    View Details Ho Y, et al. (2002) AHA1 ARP2 AVO1 BEM3 BRX1 BTN2 BUD3 CAF4 CCT2 CCT3 CCT5 CCT6 CDC20 CDC28 CDC55 CDH1 CIN8 CLB2 CLU1 CMR1 COP1 CTR1 CYS4 DHH1 DIA4 DIG1 DIG2 DUN1 EAP1 ENT2 FYV10 FZO1 GAL7 GCD11 GDT1 GID7 GID8 GPA1 GUS1 HIR1 HTB1 IDH1 IME2 KRE33 KSS1 LIA1 MAD3 MDH1 MEH1 MKK2 MNP1 MOH1 MYO2 NAN1 NAP1 NEW1 NOP56 NPA3 OSH7 PEX7 PFS2 PIM1 POL5 PPH21 PPH22 PPH3 PRB1 PSY2 PSY4 PWP1 RAD28 RMD5 RNQ1 RPA135 RPN6 RPN7 RPT3 RRP12 RVB1 SEC27 SEC28 SEN2 SOF1 SRP54 SSD1 STE11 STE12 STE4 STI1 TAF5 TCP1 TEC1 TIF4631 TMA19 TPD3 TSC11 UBP15 UBR1 UTP10 UTP22 UTP7 VID28 VID30 WTM1 WTM2 YBL029W YCR076C YER160C YHR033W
    View Details Qiu et al. (2008) CCT2 CCT3 CCT4 CCT5 CCT6 CCT7 CCT8 SSA2 TCP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen IST3 CCT2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CCT2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..104]
    [139..402]
    [485..527]    		 PSI-BLAST 896.0 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
    2 View Details [105..138]
    [403..484]    		 PSI-BLAST 896.0 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  7.60116801069598 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.6934849790316 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.40373598585301 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  3.28982639907979 bayes_pls_golite062009
  • binding
    		•  2.07154556649829 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.67284737458957 bayes_pls_golite062009
  • DNA binding
    		•  1.60256620441721 bayes_pls_golite062009
  • transporter activity
    		•  1.27879339110564 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08697283907212 bayes_pls_golite062009
  • chaperone binding
    		•  0.91200031047441 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.828920415160435 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.787685249362834 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.75018875403424 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.69634667457441 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.682843768728088 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.680378643689288 bayes_pls_golite062009
  • protein binding
    		•  0.634982583867058 bayes_pls_golite062009
  • ATPase activity
    		•  0.584574936611857 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.573106450426516 bayes_pls_golite062009
  • catalytic activity
    		•  0.424959044318554 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.280310103153739 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.275534581026027 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  0.26275673855778 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.252704226951294 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.243984617084631 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.205808843369749 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.202279803135899 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.20198255686005 bayes_pls_golite062009
  • transferase activity
    		•  0.18639662517366 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.16424934648837 bayes_pls_golite062009
  • kinase activity
    		•  0.0871496920547826 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0778814959589007 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0491351110520448 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle