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Protein Overview: CDH1

General Information:
Name(s) found: CDH1 / YGL003C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 566 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    anaphase-promoting complex [TASLink to PubMed article]
    Biological Process: mitotic spindle elongation [TASLink to PubMed article]
    activation of mitotic anaphase-promoting complex activity [IMPLink to PubMed article]
    regulation of cell size [IMPLink to PubMed article]
    mitotic sister chromatid segregation [TASLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    mitotic metaphase/anaphase transition [TASLink to PubMed article]
    protein ubiquitination [IPILink to PubMed article]
    Molecular Function: enzyme activator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNLNPFMN NTPSSSPLKG SESKRVSKRP ISSSSSASLL SSPSRRSRPS TVYGDRYIPS  60
   61 RTDIDFNSIV SISSMASVPA LNPSSTEDQV EYQKERQAHE TYNTLLKNEL FGEMLSKDTV 120
  121 GSESSIDRIK NTRPSTRGNV HAENTTRHGY ELERVSTPPP EAAGLEEFSP HSTPVTPRRL 180
  181 FTSQQDEITR PSSNSVRGAS LLTYQQRKGR RLSAASLLQS QFFDSMSPVR PDSKQLLLSP 240
  241 GKQFRQIAKV PYRVLDAPSL ADDFYYSLID WSSTDVLAVA LGKSIFLTDN NTGDVVHLCD 300
  301 TENEYTSLSW IGAGSHLAVG QANGLVEIYD VMKRKCIRTL SGHIDRVACL SWNNHVLTSG 360
  361 SRDHRILHRD VRMPDPFFET IESHTQEVCG LKWNVADNKL ASGGNDNVVH VYEGTSKSPI 420
  421 LTFDEHKAAV KAMAWSPHKR GVLATGGGTA DRRLKIWNVN TSIKMSDIDS GSQICNMVWS 480
  481 KNTNELVTSH GYSKYNLTLW DCNSMDPIAI LKGHSFRVLH LTLSNDGTTV VSGAGDETLR 540
  541 YWKLFDKPKA KVQPNSLIFD AFNQIR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CCT2 CCT3 CDC28 CDH1 CLB2 NAP1 UBP15

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NOP9 No Comments Hazbun TR, et al. (2003)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] deduced N/A No confident structure predictions are available.
    2 View Details [121..458] PSI-BLAST 63.221849 Tup1, C-terminal domain
    3 View Details [459..566] PSI-BLAST 87.69897 PAF-AH Holoenzyme: Lis1/Alfa2


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.69

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle