YRC Public Data Repository - Protein Structure Prediction

Protein:	CCT2
Organism:	Saccharomyces cerevisiae
Length:	527 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCT2.

Description	E-value	Query Range	Subject Range
gi\|18978346, gi\|... - gi\|18978346\|ref\|NP_579703.1\| thermosome, single subunit [Pyrococcus furiosus DSM 3638], gi\|18894178\|...	0.0	[2..519]	[8..526]
THS_PYRHO - Thermosome subunit OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139... THS_PYRHO - Thermosome subunit OS=Pyrococcus horikoshii GN=ths PE=3 SV=1	0.0	[2..517]	[8..524]
THS_PYRAB - Thermosome subunit OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=ths PE=3 SV=1 THS_PYRAB - Thermosome subunit OS=Pyrococcus abyssi GN=ths PE=3 SV=1	0.0	[2..519]	[8..526]
THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain KS-1) GN=thsB PE=3 SV=2 THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=thsB PE=3 SV=2	0.0	[2..524]	[8..531]
THSB_AERPE - Thermosome subunit beta OS=Aeropyrum pernix GN=thsB PE=3 SV=2 THSB_AERPE - Thermosome subunit beta OS=Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138...	0.0	[1..517]	[14..532]
THSB_PYRKO - Thermosome subunit beta OS=Pyrococcus kodakaraensis GN=thsB PE=3 SV=1 THSB_THEKO - Thermosome subunit beta OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=ths... gi\|473965, gi\|21... - gi\|473965\|dbj\|BAA06143.1\| heat-shock protein [Pyrococcus sp.], pir\|\|S61294 heat-shock protein - Pyro...	0.0	[2..524]	[8..531]
gi\|7441909 - gi\|7441909\|pir\|\|C72512 probable thermosome, subunit APE2072 - Aeropyrum pernix (strain K1) gi\|5105771, gi\|1... - gi\|5105771\|dbj\|BAA81083.1\| 555aa long hypothetical thermosome, subunit [Aeropyrum pernix K1], gi\|146...	0.0	[1..517]	[21..539]
THSB_ARCFU - Thermosome subunit beta OS=Archaeoglobus fulgidus GN=thsB PE=3 SV=1 THSB_ARCFU - Thermosome subunit beta OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 /...	0.0	[2..518]	[8..525]
THS_METKA - Thermosome subunit OS=Methanopyrus kandleri GN=ths PE=3 SV=1 THS_METKA - Thermosome subunit OS=Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) GN=ths...	0.0	[3..517]	[11..526]

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Predicted Domain #1

Region A:
Residues: [1-104]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVQIFGDQV TEERAENARL SAFVGAIAVG DLVKSTLGPK GMDKLLQSAS SNTCMVTNDG  60
   61 ATILKSIPLD NPAAKVLVNI SKVQDDEVGD GTTSVTVLSA ELLR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [139-402]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVDNSHDKTM FREDLIHIAK TTLSSKILSQ DKDHFAELAT NAILRLKGST NLEHIQIIKI  60
   61 LGGKLSDSFL DEGFILAKKF GNNQPKRIEN AKILIANTTL DTDKVKIFGT KFKVDSTAKL 120
  121 AQLEKAEREK MKNKIAKISK FGINTFINRQ LIYDYPEQLF TDLGINSIEH ADFEGVERLA 180
  181 LVTGGEVVST FDEPSKCKLG ECDVIEEIML GEQPFLKFSG CKAGEACTIV LRGATDQTLD 240
  241 EAERSLHDAL SVLSQTTKET RTVL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [485-527]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGIVESYKLK RAVVSSASEA AEVLLRVDNI IRARPRTANR QHM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	896.0
Match:	1a6dA_
Description:	Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	7.60116801069598	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.6934849790316	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.40373598585301	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.28982639907979	bayes_pls_golite062009
binding	2.07154556649829	bayes_pls_golite062009
nucleic acid binding	1.67284737458957	bayes_pls_golite062009
DNA binding	1.60256620441721	bayes_pls_golite062009
transporter activity	1.27879339110564	bayes_pls_golite062009
transmembrane transporter activity	1.08697283907212	bayes_pls_golite062009
chaperone binding	0.91200031047441	bayes_pls_golite062009
substrate-specific transporter activity	0.828920415160435	bayes_pls_golite062009
ATPase activity, coupled	0.787685249362834	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.75018875403424	bayes_pls_golite062009
pyrophosphatase activity	0.69634667457441	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.682843768728088	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.680378643689288	bayes_pls_golite062009
protein binding	0.634982583867058	bayes_pls_golite062009
ATPase activity	0.584574936611857	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.573106450426516	bayes_pls_golite062009
catalytic activity	0.424959044318554	bayes_pls_golite062009
ion transmembrane transporter activity	0.280310103153739	bayes_pls_golite062009
active transmembrane transporter activity	0.275534581026027	bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism	0.26275673855778	bayes_pls_golite062009
primary active transmembrane transporter activity	0.252704226951294	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.243984617084631	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.205808843369749	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.202279803135899	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.20198255686005	bayes_pls_golite062009
transferase activity	0.18639662517366	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.16424934648837	bayes_pls_golite062009
kinase activity	0.0871496920547826	bayes_pls_golite062009
cation transmembrane transporter activity	0.0778814959589007	bayes_pls_golite062009
hydrolase activity	0.0491351110520448	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [105-138]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAEKLIDQSK IHPQTIIEGY RLASAAALDA LTKA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [403-484]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGCAEMVMS KAVDTEAQNI DGKKSLAVEA FARALRQLPT ILADNAGFDS SELVSKLRSS  60
   61 IYNGISTSGL DLNNGTIADM RQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	896.0
Match:	1a6dA_
Description:	Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: