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Protein Overview: MAD3

General Information:
Name(s) found: MAD3 / YJL013C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 515 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAYAKKRIS YMPSSPSQNV INFEEIETQK ENILPLKEGR SAAALSKAIH QPLVEINQVK  60
   61 SSFEQRLIDE LPALSDPITL YLEYIKWLNN AYPQGGNSKQ SGMLTLLERC LSHLKDLERY 120
  121 RNDVRFLKIW FWYIELFTRN SFMESRDIFM YMLRNGIGSE LASFYEEFTN LLIQKEKFQY 180
  181 AVKILQLGIK NKARPNKVLE DRLNHLLREL GENNIQLGNE ISMDSLESTV LGKTRSEFVN 240
  241 RLELANQNGT SSDVNLTKNN VFVDGEESDV ELFETPNRGV YRDGWENFDL KAERNKENNL 300
  301 RISLLEANTN LGELKQHEML SQKKRPYDEK LPIFRDSIGR SDPVYQMINT KDQKPEKIDC 360
  361 NFKLIYCEDE ESKGGRLEFS LEEVLAISRN VYKRVRTNRK HPREANLGQE ESANQKEAEA 420
  421 QSKRPKISRK ALVSKSLTPS NQGRMFSGEE YINCPMTPKG RSTETSDIIS AVKPRQLTPI 480
  481 LEMRESNSFS QSKNSEIISD DDKSSSSFIS YPPQR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CCT2 CCT3 CCT5 CDC20 MAD3 MDH1 MKK2 TCP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MAD3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..265] ORFEUS 7.6 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    2 View Details [266..389] deduced N/A No confident structure predictions are available.
    3 View Details [390..515] MSA 1.009976 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle