Protein Overview: LYS12

General Information:
Name(s) found:	LYS12 / YIL094C [SGD]
Description(s) found: Found 28 descriptions. SHOW ALL	Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate [SGD]
Organism:	Saccharomyces cerevisiae
Length:	371 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ]
Biological Process:	lysine biosynthetic process [TAS]
Molecular Function:	homoisocitrate dehydrogenase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRSVATRLS ACRGLASNAA RKSLTIGLIP GDGIGKEVIP AGKQVLENLN SKHGLSFNFI  60
   61 DLYAGFQTFQ ETGKALPDET VKVLKEQCQG ALFGAVQSPT TKVEGYSSPI VALRREMGLF 120
  121 ANVRPVKSVE GEKGKPIDMV IVRENTEDLY IKIEKTYIDK ATGTRVADAT KRISEIATRR 180
  181 IATIALDIAL KRLQTRGQAT LTVTHKSNVL SQSDGLFREI CKEVYESNKD KYGQIKYNEQ 240
  241 IVDSMVYRLF REPQCFDVIV APNLYGDILS DGAAALVGSL GVVPSANVGP EIVIGEPCHG 300
  301 SAPDIAGKGI ANPIATIRST ALMLEFLGHN EAAQDIYKAV DANLREGSIK TPDLGGKAST 360
  361 QQVVDDVLSR L

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		LYS12 SAM1
View Details	Krogan NJ, et al. (2006)		ART5 JID1 LYS12 OSH6 YHR138C
View Details	Gavin AC, et al. (2006)		IDH2 LYS12
View Details	Gavin AC, et al. (2002)		ACC1 ACT1 ASC1 ATP2 BLM10 BMH1 BMH2 CCT8 CDC45 CDC73 CHC1 CKA1 CKA2 CKB1 CKB2 CLC1 CLU1 CPA2 CRM1 CTR9 DAM1 DBP9 ECM29 ERG13 ERG26 EST3 FDH1 FKS1 GCN1 GCN20 GEA2 GFA1 GGA2 GIN4 GLT1 GUS1 HAT1 HRP1 HSP42 HTZ1 ILV1 IML1 INO4 KAP104 KAP114 KAP123 KAP95 KCC4 LCB1 LCB2 LEO1 LYS12 MCM2 MCM5 MCM6 MCM7 MDS3 MIR1 MRPL3 NAB2 NAP1 NBA1 NCS2 NIS1 NUD1 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PAF1 PDA1 PDB1 POB3 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE8 PRE9 PSA1 PSE1 PUP3 RGR1 RPA135 RPB2 RPD3 RPN10 RPN11 RPN12 RPN8 RPN9 RPT3 RPT5 RPT6 RRN3 RRP12 RTF1 SAM1 SAM2 SCL1 SEC27 SIN3 SLX9 SMC3 SPA2 SPT16 SRP1 SSC1 TCB1 TFP1 TIF1, TIF2 TSA1 TUB3 ULP1 URA7 VAS1 YFL006W YHB1 YHR020W YMR310C YNL313C YOL098C YRA1
View Details	Ho Y, et al. (2002)		ACC1 ADR1 AHA1 ARP2 ATP3 BCK1 BUL1 CCT3 COP1 CPA2 CPR6 DED1 DEF1 EGD2 FOL2 GAL7 GND1 GYP5 IDH1 ILV5 IPP1 KIC1 KIN2 LHS1 LSC1 LST8 LYS12 MET18 MKK2 MKT1 NPA3 OYE2 PDC6 PHO84 PHO86 PIL1 PMA1 POR1 PRB1 PRE10 QCR2 RCN2 RGD1 RNQ1 RPN1 RPN12 RPN6 RPN7 RPT3 RRP3 RVB1 RVS167 SIP1 SIS1 SKG3 SLC1 SLT2 SMK1 STI1 TIF1, TIF2 URA7 YBT1 YKU80 YLR243W YML020W

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB	Keck JM, et al. (2011)
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	APC5	LYS12	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	LYS12	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..371]	PSI-BLAST	561.9794	3-isopropylmalate dehydrogenase, IPMDH

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2