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Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: homoisocitrate dehydrogenase activity
Acc: GO:0047046
Aspect: Molecular Function
Desc: Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.
Synonyms:
  • (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity
  • 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)
  • 2-hydroxy-3-carboxyadipate dehydrogenase activity
  • homoisocitric dehydrogenase activity
  • GO:0047984
  • (-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)
  • 3-carboxy-2-hydroxyadipate dehydrogenase activity
  • 3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity
  • (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0047046 - homoisocitrate dehydrogenase activity (interactive image map)
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