Protein Overview: FOL2

General Information:
Name(s) found:	FOL2 / YGR267C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321706\|ref\|NP_011783.1\| GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway; Fol2p [Saccharomyces cerevisiae] [NCBI NR] gi\|51013437\|gb\|AAT93012.1\| YGR267C [Saccharomyces cerevisiae] [NCBI NR] pir\|\|JC4585 GTP cyclohydrolase I (EC 3.5.4.16) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1730247\|sp\|P51601.1\|GCH1_YEAST RecName: Full=GTP cyclohydrolase 1; AltName: Full=GTP cyclohydrolase I; Short=GTP-CH-I [NCBI NR] gi\|1556436\|emb\|CAA69198.1\| GTP cyclohydrolase i [Saccharomyces cerevisiae] [NCBI NR] gi\|1478321\|gb\|AAB36000.1\| ORF243/GTP-cyclohydrolase I homolog {EC 3.5.4.16} [Saccharomyces cerevisiae=yeast, FY1679, Peptide, 243 aa] [NCBI NR] gi\|1360143\|emb\|CAA63975.1\| GTP-cyclohydrolase I [Saccharomyces cerevisiae] [NCBI NR] gi\|1323486\|emb\|CAA97297.1\| FOL2 [Saccharomyces cerevisiae] [NCBI NR] GTP cyclohydrolase 1 OS=Saccharomyces cerevisiae GN=FOL2 PE=1 SV=1 [Swiss-Prot] FOL2 GTP cyclohydrolase I [mips] GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway [SGD] FOL2, Chr VII from 1025001-1025732, reverse complement [yeast_orfs2] Chr VII from 1025001-1025732, reverse complement [yeastorf3.fasta] Chr VII from 1025008-1025739, reverse complement [yeastorf4.fasta] Chr VII from 1025739-1025008, reverse complement [yeastorf5.fasta] (P51601) GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I) [4932.FASTACCERV.txt] FOL2 SGDID:S0003499, Chr VII from 1025740-1025009, reverse complement, Verified ORF [yeastflysequest.fasta] FOL2 SGDID:S0003499, Chr VII from 1025741-1025010, reverse complement, Verified ORF [10112005cervSGD.fasta] Fol2p [Saccharomyces cerevisiae]gi\|51013437\|gb\|AAT93012.1\| YGR267C [Saccharomyces cerevisiae]gi\|1360143\|emb\|CAA63975.1\| GTP-cyclohydrolase I [Saccharomyces cerevisiae]gi\|1323486\|emb\|CAA97297.1\| FOL2 [Saccharomyces cerevisiae]gi\|1556436\|emb\|CAA69198.1\| [nrdb_11152004_Chlamydomonas] FOL2 SGDID:S000003499, Chr VII from 1025741-1025010, reverse complement, Verified ORF, "GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway; Fol2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ORF243/GTP-cyclohydrolase I homolog {EC 3.5.4.16} [Saccharomyces cerevisiae=yeast, FY1679, Peptide, 243 aa] [nr-271106-contam.fasta] YGR267C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] GTP cyclohydrolase I (GTP-CH-I) [nr-271106-contam.fasta] GTP-cyclohydrolase I [Saccharomyces cerevisiae] [nr-271106-contam.fasta] GTP cyclohydrolase i [Saccharomyces cerevisiae] [nr-271106-contam.fasta] FOL2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] GTP cyclohydrolase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FOL2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] FOL2 SGDID:S000003499, Chr VII from 1025735-1025004, Genome Release 64-1-1, reverse complement, Verified ORF, "GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway" [yeast-030211-contam.fasta] FOL2 SGDID:S000003499, Chr VII from 1025735-1025004, Genome Release 64-2-1, reverse complement, Verified ORF, "GTP-cyclohydrolase I; catalyzes the first step in the folic acid biosynthetic pathway" [20141208_orf_trans.fasta] TR7938\|c0_g1_i1\|g.5491 ORF TR7938\|c0_g1_i1\|g.5491 TR7938\|c0_g1_i1\|m.5491 type:complete len:244 (+) TR7938\|c0_g1_i1:1303-2034(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR4832\|c0_g1_i1\|g.3204 ORF TR4832\|c0_g1_i1\|g.3204 TR4832\|c0_g1_i1\|m.3204 type:complete len:244 (+) TR4832\|c0_g1_i1:1302-2033(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YGR267C SGDID:S000003499, Chr VII from 1025735-1025004, Genome Release 64-1-1, reverse complement, Verified ORF, "GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_1645\|g.1481 ORF asmbl_1645\|g.1481 asmbl_1645\|m.1481 type:complete len:244 (+) asmbl_1645:1301-2032(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_1702\|g.1528 ORF asmbl_1702\|g.1528 asmbl_1702\|m.1528 type:3prime_partial len:244 (+) asmbl_1702:1301-2029(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_1650\|g.831 ORF ID=asmbl_1650\|g.831 ID=asmbl_1650\|m.831 type:complete len:244 (+) ID=asmbl_1650:1301-2032(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_1707\|g.805 ORF ID=asmbl_1707\|g.805 ID=asmbl_1707\|m.805 type:3prime_partial len:244 (+) ID=asmbl_1707:1301-2029(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	243 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA ]
Biological Process:	folic acid and derivative biosynthetic process [IMP]
Molecular Function:	GTP cyclohydrolase I activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHNIQLVQEI ERHETPLNIR PTSPYTLNPP VERDGFSWPS VGTRQRAEET EEEEKERIQR  60
   61 ISGAIKTILT ELGEDVNREG LLDTPQRYAK AMLYFTKGYQ TNIMDDVIKN AVFEEDHDEM 120
  121 VIVRDIEIYS LCEHHLVPFF GKVHIGYIPN KKVIGLSKLA RLAEMYARRL QVQERLTKQI 180
  181 AMALSDILKP LGVAVVMEAS HMCMVSRGIQ KTGSSTVTSC MLGGFRAHKT REEFLTLLGR 240
  241 RSI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		FOL2 POR1
View Details	Krogan NJ, et al. (2006)		AEP3 CDC20 FAB1 FOL2 GZF3 LSP1 NOP13 PIL1 PKH1 PRP16 PSK2 RGC1 RPL9B YLR179C YMR086W YTA6
View Details	Ho Y, et al. (2002)		AAC3 ACC1 ADH2 ADR1 AHA1 AHP1 ARP2 ARP4 ASA1 ATG17 ATG29 ATP3 BCK1 BEM2 CAR2 CCT3 CDC33 CDC53 CIC1 CIS1 COF1 COP1 CPA2 CPR1 CPR6 CYS4 DEF1 DUF1 EDE1 EGD2 FOL2 GAL7 GND1 GRH1 GRR1 HAP2 HAP5 HTB2 HYP2 IDH1 ILV5 IPP1 KIC1 KIN2 LHS1 LOC1 LSC1 LST8 LYS1 LYS12 MAM33 MKK2 MKT1 MPC54 MTQ1 NAP1 NIP1 NMD5 NOP16 NSA2 OYE2 OYE3 PDC5 PDC6 PFK1 PHO86 PIL1 PMA1 POL5 POR1 PSE1 PST2 PYC2 QCR2 RCN2 RHR2 RPG1 RPN12 RPN6 RPT3 RRP3 SAH1 SAP190 SER1 SES1 SIP1 SIS1 SKG3 SKP1 SLC1 SLT2 SMK1 SOD1 SPE3 SRV2 SSK2 STI1 TAL1 TIF1, TIF2 TIF34 TIF35 TIF6 UBA1 UBI4 YBL108W YBT1 YCK1 YHR112C YKU80 YML020W YRA1 YRA2 YTM1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	FOL2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..243]	PSI-BLAST	735.522879	GTP cyclohydrolase I

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Protein Overview: FOL2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: